HitPredict

Interactor 1: BTG3 (Q14201)
Protein BTG3 (Abundant in neuroepithelium area protein) (BTG family member 3) (Protein Tob5)
Gene: BTG3

Interactor 2: CNOT7 (Q9UIV1)
CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a)
Gene: CNOT7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BTG~CAF1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 252 Hs			1 285
+	Hs
		1051204 BTG3_HUMAN (1-252): 6.37e-141: 397: 100.00		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Mm
		251045 BTG4_MOUSE (1-250): 5.42e-118: 339: 41.18		CNOT7_MOUSE (1-285): 0: 501: 99.65
+	Mm
		251046 BTG4_MOUSE (1-250): 5.42e-118: 339: 41.18		CNOT8_MOUSE (1-282): 1.11e-171: 477: 76.24
+	Hs
		841404 TOB1_HUMAN (1-136): 1.52e-66: 211: 33.33		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Hs
		1048317 TOB2_HUMAN (1-136): 3.12e-60: 195: 30.44		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Hs
		841403 TOB1_HUMAN (1-136): 1.52e-66: 211: 33.33		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Hs
		1048316 TOB2_HUMAN (1-136): 3.12e-60: 195: 30.44		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Hs
		1152299 Q6IBC8_HUMAN (1-115): 6.6e-52: 168: 40.17		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Hs
		912794 BTG1_HUMAN (1-115): 6.6e-52: 168: 40.17		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Mm
		912801 BTG1_MOUSE (1-115): 6.6e-52: 168: 40.17		CNOT7_MOUSE (1-285): 0: 501: 99.65
+	Hs
		944599 BTG2_HUMAN (1-115): 1.84e-51: 166: 41.03		CNOT7_HUMAN (1-285): 0: 502: 100.00
+	Mm
		978994 BTG2_MOUSE (1-115): 2.19e-51: 166: 41.03		CNOT7_MOUSE (1-285): 0: 501: 99.65
+	Hs
		1152298 Q6IBC8_HUMAN (1-115): 6.6e-52: 168: 40.17		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Hs
		912793 BTG1_HUMAN (1-115): 6.6e-52: 168: 40.17		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Mm
		912802 BTG1_MOUSE (1-115): 6.6e-52: 168: 40.17		CNOT8_MOUSE (1-282): 1.11e-171: 477: 76.24
+	Hs
		944598 BTG2_HUMAN (1-115): 1.84e-51: 166: 41.03		CNOT8_HUMAN (1-282): 6.3e-172: 478: 76.24
+	Mm
		978995 BTG2_MOUSE (1-115): 2.19e-51: 166: 41.03		CNOT8_MOUSE (1-282): 1.11e-171: 477: 76.24
+	Dm
		1155377 Q6NQY2_DROME (1-136): 6.33e-57: 191: 34.53		Q9VTS4_DROME (2-273): 2.28e-156: 439: 72.26
+	Dm
		60235 A4V4L0_DROME (1-136): 2.17e-55: 187: 34.78		X2JCC3_DROME (2-256): 5.58e-145: 412: 68.87