HitPredict

Interactor 1: GSK3B (P49841)
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Gene: GSK3B

Interactor 2: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

The method score is based on:

Property	Details
Experiments	18172167, 21310903
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 10 others more... GO:0008013 - beta-catenin binding GO:0010628 - positive regulation of gene expression GO:0010629 - negative regulation of gene expression GO:0019901 - protein kinase binding GO:0030154 - cell differentiation GO:0031625 - ubiquitin protein ligase binding GO:0043066 - negative regulation of apoptotic process GO:0045668 - negative regulation of osteoblast differentiation GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0097191 - extrinsic apoptotic signaling pathway
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	420
Hs

1	425

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024