Protein: KPCD
Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]

Gene: KPCD, PRKCD
Organism: Homo sapiens
Interactions: 165
UniProt ID: Q05655

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004697 - diacylglycerol-dependent serine/threonine kinase activity
GO:0004699 - diacylglycerol-dependent, calcium-independent serine/threonine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1051910

KPCD
Protein kinase C delta type

8

17

Small-scale

0.954

High

838070

STAT1
Signal transducer and activator of transcription 1-alpha/beta

5

7

Small-scale

0.944

High

711321

SHC1
SHC-transforming protein 1

5

14

Small-scale

0.929

High

1051928

ELAV1
ELAV-like protein 1

4

5

Small-scale

0.910

High

464927

SP1
Transcription factor Sp1

3

3

Small-scale

0.845

High

436662

KPCB
Protein kinase C beta type

2

16

High-throughput

0.811

High

1048280

KPCT
Protein kinase C theta type

2

18

High-throughput

0.811

High

1051945

NGEF
Ephexin-1

2

12

High-throughput

0.811

High

822629

VHL
von Hippel-Lindau disease tumor suppressor

2

7

Small-scale

0.806

High

1051920

SQSTM
Sequestosome-1

2

13

Small-scale

0.806

High

440505

FYN
Tyrosine-protein kinase Fyn

2

17

Small-scale

0.789

High

772487

IRS1
Insulin receptor substrate 1

2

7

Small-scale

0.768

High

241472

PRKN
E3 ubiquitin-protein ligase parkin

2

16

High-throughput

0.754

High

439708

INSR
Insulin receptor

2

18

Small-scale

0.754

High

943921

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

2

9

Small-scale

0.754

High

1051964

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

2

7

Small-scale

0.754

High

167878

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

20

Small-scale

0.747

High

711107

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

6

Small-scale

0.747

High

177852

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.724

High

827753

STAT3
Signal transducer and activator of transcription 3

1

7

Small-scale

0.724

High

857426

NOTC1
Neurogenic locus notch homolog protein 1

1

3

Small-scale

0.724

High

1051943

GRP3
Ras guanyl-releasing protein 3

1

8

Small-scale

0.724

High

193558

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

19

Small-scale

0.713

High

572918

INSRR
Insulin receptor-related protein

1

18

High-throughput

0.691

High

603247

KPCA
Protein kinase C alpha type

1

16

High-throughput

0.691

High

626458

NCF2
Neutrophil cytosol factor 2

1

13

Small-scale

0.691

High

1051922

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

20

High-throughput

0.691

High

1051924

IL27B
Interleukin-27 subunit beta

1

8

High-throughput

0.691

High

1051932

ACTBL
Beta-actin-like protein 2

1

8

High-throughput

0.691

High

1051946

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

2

High-throughput

0.691

High

663755

IL32
Interleukin-32

4

3

Small-scale

0.691

High

461390

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.647

High

891130

GSK3A
Glycogen synthase kinase-3 alpha

1

18

Small-scale

0.647

High

1051916

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

19

Small-scale

0.647

High

1051944

AFAP1
Actin filament-associated protein 1

1

5

Small-scale

0.647

High

1051981

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

5

Small-scale

0.647

High

622589

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

8

Small-scale

0.646

High

186736

P73
Tumor protein p73

2

4

Small-scale

0.634

High

820623

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.631

High

413681

P53
Cellular tumor antigen p53

2

4

Small-scale

0.621

High

216933

KLF4
Krueppel-like factor 4

1

6

Small-scale

0.618

High

362255

ABL1
Tyrosine-protein kinase ABL1

1

17

Small-scale

0.618

High

466219

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

557247

SRC
Proto-oncogene tyrosine-protein kinase Src

1

17

Small-scale

0.618

High

728188

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

Small-scale

0.618

High

820530

IL6RB
Interleukin-6 receptor subunit beta

1

2

Small-scale

0.618

High

905547

IRAK1
Interleukin-1 receptor-associated kinase 1

1

5

Small-scale

0.618

High

961981

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

966226

1433G
14-3-3 protein gamma

1

20

Small-scale

0.618

High

977954

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

990131

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.618

High

1051919

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.618

High

1051925

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.618

High

1051934

PPRC1
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

1

9

High-throughput

0.618

High

1051937

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

1051952

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

1

Small-scale

0.618

High

1051965

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.618

High

1051968

TLR9
Toll-like receptor 9

1

6

Small-scale

0.618

High

1051976

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

4

Small-scale

0.618

High

1051977

IBTK
Inhibitor of Bruton tyrosine kinase

1

6

Small-scale

0.618

High

1051978

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

3

Small-scale

0.618

High

421972

A4
Amyloid-beta precursor protein

2

7

High-throughput

0.611

High

899850

FXR1
RNA-binding protein FXR1

2

5

High-throughput

0.611

High

542473

TOP2A
DNA topoisomerase 2-alpha

1

6

Small-scale

0.603

High

595409

H15
Histone H1.5

2

19

Small-scale

0.602

High

1037127

H11
Histone H1.1

2

19

Small-scale

0.602

High

839246

MTOR
Serine/threonine-protein kinase mTOR

2

9

Small-scale

0.601

High

1051911

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

4

Small-scale

0.589

High

572813

NCF1
Neutrophil cytosol factor 1

2

13

Small-scale

0.585

High

334173

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

2

2

Small-scale

0.584

High

590273

MUC1
Mucin-1

1

3

Small-scale

0.578

High

96001

E7EVG6
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

1

7

High-throughput

0.575

High

729769

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.575

High

168845

PLD2
Phospholipase D2

1

2

Small-scale

0.561

High

221119

SPY2
Protein sprouty homolog 2

1

1

Small-scale

0.561

High

1030955

FLI1
Friend leukemia integration 1 transcription factor

1

2

Small-scale

0.561

High

1051961

CAR11
Caspase recruitment domain-containing protein 11

1

12

Small-scale

0.549

High

63856

TPC13
Trafficking protein particle complex subunit 13

1

1

High-throughput

0.536

High

238888

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

2

High-throughput

0.536

High

712189

TKT
Transketolase

1

5

High-throughput

0.536

High

913761

ZN131
Zinc finger protein 131

1

2

High-throughput

0.536

High

961704

RL37A
Large ribosomal subunit protein eL43

1

1

High-throughput

0.536

High

1051931

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

1

High-throughput

0.536

High

1051949

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.536

High

1051956

OPALI
Opalin

1

1

High-throughput

0.536

High

1051957

DUX3
Putative double homeobox protein 3

1

5

High-throughput

0.536

High

1051960

BUD13
BUD13 homolog

1

3

High-throughput

0.536

High

1051972

BEX4
Protein BEX4

1

1

High-throughput

0.536

High

1051985

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

607297

NEUM
Neuromodulin

1

0

Small-scale

0.530

High

1051930

FSCN1
Fascin

2

3

Small-scale

0.518

High

1051913

TROP
Trophinin

1

3

Small-scale

0.515

High

1051980

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

6

Small-scale

0.515

High

1051984

TRAF6
TNF receptor-associated factor 6

1

15

Small-scale

0.515

High

1051962

PIP30
PSME3-interacting protein

1

0

High-throughput

0.513

High

1051971

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1051975

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

High-throughput

0.513

High

1051966

CDCP1
CUB domain-containing protein 1

1

0

Small-scale

0.512

High

388064

MBP
Myelin basic protein

1

6

Small-scale

0.501

High

424074

ITB2
Integrin beta-2

1

15

Small-scale

0.501

High

761648

HSP74
Heat shock 70 kDa protein 4

1

15

Small-scale

0.501

High

934510

TERA
Transitional endoplasmic reticulum ATPase

1

5

Small-scale

0.501

High

994186

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

13

Small-scale

0.501

High

1022150

DAB2
Disabled homolog 2

1

12

Small-scale

0.501

High

1040965

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

8

Small-scale

0.501

High

1051912

EP300
Histone acetyltransferase p300

1

10

Small-scale

0.501

High

1051923

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

Small-scale

0.501

High

1051926

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

8

Small-scale

0.501

High

1051927

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

3

Small-scale

0.501

High

1051982

HDAC5
Histone deacetylase 5

1

6

Small-scale

0.501

High

1051983

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

2

Small-scale

0.501

High

1051967

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

Small-scale

0.493

High

1051970

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.493

High

1051979

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.493

High

1051921

NAR3
Ecto-ADP-ribosyltransferase 3

1

0

Small-scale

0.480

High

1051941

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

0

Small-scale

0.480

High

1051969

PLS3
Phospholipid scramblase 3

1

0

Small-scale

0.480

High

173905

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

6

High-throughput

0.479

High

345700

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

371836

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

415520

HSPB1
Heat shock protein beta-1

1

14

Small-scale

0.479

High

418082

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

540250

SPTB1
Spectrin beta chain, erythrocytic

1

5

High-throughput

0.479

High

540416

LAMP1
Lysosome-associated membrane glycoprotein 1

1

6

High-throughput

0.479

High

562014

LAMP2
Lysosome-associated membrane glycoprotein 2

1

6

High-throughput

0.479

High

576646

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

3

Small-scale

0.479

High

588524

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

609924

SPI1
Transcription factor PU.1

1

3

Small-scale

0.479

High

675003

TNR6
Tumor necrosis factor receptor superfamily member 6

1

8

High-throughput

0.479

High

766476

PHB1
Prohibitin 1

1

4

Small-scale

0.479

High

791321

SYUA
Alpha-synuclein

1

6

Small-scale

0.479

High

839147

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

8

Small-scale

0.479

High

872238

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.479

High

951113

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

1045204

TF65
Transcription factor p65

1

11

High-throughput

0.479

High

1051915

FOXC1
Forkhead box protein C1

1

7

High-throughput

0.479

High

1051917

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

13

Small-scale

0.479

High

1051918

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

1

Small-scale

0.479

High

1051929

CCDC6
Coiled-coil domain-containing protein 6

1

7

High-throughput

0.479

High

1051936

RBP10
Ran-binding protein 10

1

5

Small-scale

0.479

High

1051938

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1051939

TRI69
E3 ubiquitin-protein ligase TRIM69

1

7

Small-scale

0.479

High

1051940

GOLI
E3 ubiquitin-protein ligase RNF130

1

5

High-throughput

0.479

High

1051948

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

1051950

TRI41
E3 ubiquitin-protein ligase TRIM41

1

8

Small-scale

0.479

High

1051951

AKAP1
A-kinase anchor protein 1, mitochondrial

1

4

High-throughput

0.479

High

1051958

RANB9
Ran-binding protein 9

1

5

Small-scale

0.479

High

1051963

P63
Tumor protein 63

1

4

Small-scale

0.479

High

1051974

MTCH1
Mitochondrial carrier homolog 1

1

16

High-throughput

0.479

High

129001

MEN1
Menin

1

0

High-throughput

0.458

High

1051947

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1051953

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.458

High

1051954

T53I1
Tumor protein p53-inducible nuclear protein 1

1

0

Small-scale

0.458

High

1051959

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

256842

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.445

High

1039483

TOP2B
DNA topoisomerase 2-beta

1

6

Small-scale

0.445

High

1051914

TRAF2
TNF receptor-associated factor 2

1

13

Small-scale

0.445

High

1051933

HABP4
Intracellular hyaluronan-binding protein 4

1

5

Small-scale

0.445

High

1051935

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

1051973

BCLF1
Bcl-2-associated transcription factor 1

1

2

Small-scale

0.445

High

90923

C6GKH1
Interleukin 32

1

3

Small-scale

0.437

High

756159

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.426

High

1051942

LYSM2
LysM and putative peptidoglycan-binding domain-containing protein 2

1

0

High-throughput

0.279

Low

1051955

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025