HitPredict

Interactor 1: DYHC1 (Q14204)
Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)
Gene: DYNC1H1

Interactor 2: KTNB1 (Q9BVA0)
Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin)
Gene: KATNB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	16203747, 26929214
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	AAA_8~WD40, AAA_9~WD40, DHC_N1~WD40
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0005874 - microtubule GO:0016020 - membrane GO:0031122 - cytoplasmic microtubule organization and 1 others more... GO:0051301 - cell division
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 4646 Hs			1 655
+	Hs
		1051633 DYHC1_HUMAN (1-4646): 0: 4190: 100.00		FBXW7_HUMAN (48-344): 6.46e-76: 258: 22.52
+	Mm
		925844 DYHC1_MOUSE (1-4646): 0: 4205: 99.16		LIS1_MOUSE (227-420): 5.01e-27: 115: 14.29
+	Hs
		792984 DYHC1_HUMAN (1-4646): 0: 4190: 100.00		LIS1_HUMAN (227-420): 5.51e-27: 115: 14.29
+	Hs
		903222 DYHC1_HUMAN (1-4646): 0: 4190: 100.00		WDR5_HUMAN (267-467): 4.91e-13: 72.8: 8.33
+	Dm
		741114 DYHC_DROME (23-4645): 0: 3964: 71.40		LIS1_DROME (141-410): 1.37e-48: 177: 14.68
+	Hs
		209492 DYH17_HUMAN (109-4645): 0: 3714: 23.30		PLRG1_HUMAN (11-323): 1.18e-86: 282: 24.52
+	Ce
		1090472 DYHC_CAEEL (37-4643): 0: 3576: 55.20		LIS1_CAEEL (99-383): 9.61e-67: 226: 19.14