Protein: NMDE2
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B)

Gene: NMDE2, Grin2b
Organism: Mus musculus
Interactions: 137
UniProt ID: Q01097

Gene Ontology (top 5):
GO:0001662 - behavioral fear response
GO:0001701 - in utero embryonic development
GO:0001964 - startle response
GO:0001967 - suckling behavior
GO:0004972 - NMDA glutamate receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

771464

NMDZ1
Glutamate receptor ionotropic, NMDA 1

10

20

Small-scale

0.969

High

771414

NMDE1
Glutamate receptor ionotropic, NMDA 2A

3

18

Small-scale

0.834

High

1029186

NMDE2
Glutamate receptor ionotropic, NMDA 2B

3

18

Small-scale

0.805

High

1029202

DLG4
Disks large homolog 4

18

20

Small-scale

0.763

High

548944

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

8

16

Small-scale

0.737

High

104513

SYGP1
Ras/Rap GTPase-activating protein SynGAP

5

11

High-throughput

0.714

High

1029244

DLGP1
Disks large-associated protein 1

3

12

High-throughput

0.660

High

1021857

GRM1
Metabotropic glutamate receptor 1

1

14

High-throughput

0.646

High

1029236

NETO1
Neuropilin and tolloid-like protein 1

1

8

Small-scale

0.646

High

1029220

DAPK1
Death-associated protein kinase 1

2

20

Small-scale

0.633

High

663086

GRIA2
Glutamate receptor 2

1

18

High-throughput

0.618

High

1029194

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

11

High-throughput

0.611

High

1029245

ACTN2
Alpha-actinin-2

2

9

Small-scale

0.594

High

1021884

CXAR
Coxsackievirus and adenovirus receptor homolog

1

0

High-throughput

0.586

High

431340

SRC
Proto-oncogene tyrosine-protein kinase Src

2

12

Small-scale

0.584

High

932612

PTN5
Tyrosine-protein phosphatase non-receptor type 5

2

15

Small-scale

0.571

High

1013560

TNIK
Traf2 and NCK-interacting protein kinase

1

8

High-throughput

0.536

High

1029191

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

10

High-throughput

0.536

High

1029212

Q6ZWQ9
Myosin, light chain 12A, regulatory, non-sarcomeric

2

2

Small-scale

0.533

High

704211

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

16

High-throughput

0.500

High

810514

DYN1
Dynamin-1

1

1

High-throughput

0.500

High

857218

NSF
Vesicle-fusing ATPase

1

6

High-throughput

0.500

High

993973

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

5

High-throughput

0.500

High

997242

TBA1A
Tubulin alpha-1A chain

1

9

High-throughput

0.500

High

999782

DLG3
Disks large homolog 3

1

20

High-throughput

0.500

High

1029241

DLG2
Disks large homolog 2

1

20

High-throughput

0.500

High

1029205

INADL
InaD-like protein

1

20

Small-scale

0.481

High

59052

F1712
Protein FAM171A2

1

2

High-throughput

0.479

High

60082

KALRN
Kalirin

1

20

High-throughput

0.479

High

64322

KCNB2
Potassium voltage-gated channel subfamily B member 2

1

3

High-throughput

0.479

High

92623

AKAP5
A-kinase anchor protein 5

1

1

High-throughput

0.479

High

108646

G3X9H5
Huntingtin

1

3

High-throughput

0.479

High

205675

CTND2
Catenin delta-2

1

7

High-throughput

0.479

High

237230

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

3

High-throughput

0.479

High

237413

SGMR1
Sigma non-opioid intracellular receptor 1

1

2

Small-scale

0.479

High

312263

DHCR7
7-dehydrocholesterol reductase

1

1

High-throughput

0.479

High

313197

LIN7C
Protein lin-7 homolog C

1

20

Small-scale

0.479

High

424709

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

6

High-throughput

0.479

High

464661

SPTA1
Spectrin alpha chain, erythrocytic 1

1

16

High-throughput

0.479

High

564870

NCAM1
Neural cell adhesion molecule 1

1

4

High-throughput

0.479

High

580361

CADH2
Cadherin-2

1

2

High-throughput

0.479

High

591039

KPCE
Protein kinase C epsilon type

1

12

High-throughput

0.479

High

616106

KS6A1
Ribosomal protein S6 kinase alpha-1

1

6

High-throughput

0.479

High

631783

MTAP2
Microtubule-associated protein 2

1

1

High-throughput

0.479

High

686955

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

17

High-throughput

0.479

High

723728

CTND1
Catenin delta-1

1

8

High-throughput

0.479

High

725577

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

4

High-throughput

0.479

High

728905

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

6

High-throughput

0.479

High

813511

FYN
Tyrosine-protein kinase Fyn

1

12

Small-scale

0.479

High

878600

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

953799

CDC42
Cell division control protein 42 homolog

1

4

High-throughput

0.479

High

982147

RAP1A
Ras-related protein Rap-1A

1

10

High-throughput

0.479

High

988879

RAC1
Ras-related C3 botulinum toxin substrate 1

1

4

High-throughput

0.479

High

989547

MK01
Mitogen-activated protein kinase 1

1

3

High-throughput

0.479

High

989682

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

High-throughput

0.479

High

993932

KPCG
Protein kinase C gamma type

1

14

High-throughput

0.479

High

993953

RALA
Ras-related protein Ral-A

1

6

High-throughput

0.479

High

993995

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

6

High-throughput

0.479

High

995928

ACTC
Actin, alpha cardiac muscle 1

1

5

High-throughput

0.479

High

998174

KPCB
Protein kinase C beta type

1

14

High-throughput

0.479

High

1029187

CTNB1
Catenin beta-1

1

4

High-throughput

0.479

High

1029188

NF1
Neurofibromin

1

11

High-throughput

0.479

High

1029189

F171B
Protein FAM171B

1

2

High-throughput

0.479

High

1029190

PSD3
PH and SEC7 domain-containing protein 3

1

1

High-throughput

0.479

High

1029192

TEN4
Teneurin-4

1

2

High-throughput

0.479

High

1029195

SRC8
Src substrate cortactin

1

12

High-throughput

0.479

High

1029196

PPP5
Serine/threonine-protein phosphatase 5

1

8

High-throughput

0.479

High

1029197

SHC3
SHC-transforming protein 3

1

19

Small-scale

0.479

High

1029199

RASH
GTPase HRas

1

6

High-throughput

0.479

High

1029200

DSG1A
Desmoglein-1-alpha

1

4

High-throughput

0.479

High

1029201

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

3

High-throughput

0.479

High

1029203

MK03
Mitogen-activated protein kinase 3

1

3

High-throughput

0.479

High

1029204

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

12

High-throughput

0.479

High

1029206

5HT1A
5-hydroxytryptamine receptor 1A

1

8

Small-scale

0.479

High

1029207

CLH1
Clathrin heavy chain 1

1

4

High-throughput

0.479

High

1029208

DLGP3
Disks large-associated protein 3

1

12

High-throughput

0.479

High

1029209

NEB2
Neurabin-2

1

20

High-throughput

0.479

High

1029210

KCD12
BTB/POZ domain-containing protein KCTD12

1

10

High-throughput

0.479

High

1029211

TAOK2
Serine/threonine-protein kinase TAO2

1

11

High-throughput

0.479

High

1029214

PLPR4
Phospholipid phosphatase-related protein type 4

1

2

High-throughput

0.479

High

1029216

PLPR3
Phospholipid phosphatase-related protein type 3

1

2

High-throughput

0.479

High

1029217

PCDH8
Protocadherin-8

1

1

High-throughput

0.479

High

1029218

LRRC7
Leucine-rich repeat-containing protein 7

1

4

High-throughput

0.479

High

1029219

AGRL3
Adhesion G protein-coupled receptor L3

1

3

High-throughput

0.479

High

1029221

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

9

High-throughput

0.479

High

1029223

RHG32
Rho GTPase-activating protein 32

1

1

Small-scale

0.479

High

1029227

LRC4C
Leucine-rich repeat-containing protein 4C

1

5

High-throughput

0.479

High

1029228

MGLYR
Metabotropic glycine receptor

1

7

High-throughput

0.479

High

1029229

ELFN1
Protein ELFN1

1

7

High-throughput

0.479

High

1029230

PDE10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

1

1

Small-scale

0.479

High

1029237

OTU7A
OTU domain-containing protein 7A

1

1

High-throughput

0.479

High

1029238

WASF1
Actin-binding protein WASF1

1

1

High-throughput

0.479

High

1029239

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

3

High-throughput

0.479

High

1029243

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

14

High-throughput

0.479

High

1029246

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.479

High

1029247

FAK2
Protein-tyrosine kinase 2-beta

1

20

High-throughput

0.479

High

1029250

SYT11
Synaptotagmin-11

1

3

High-throughput

0.479

High

1029251

SEPT6
Septin-6

1

3

High-throughput

0.479

High

1029252

ARC
Activity-regulated cytoskeleton-associated protein

1

1

High-throughput

0.479

High

1029253

E41L3
Band 4.1-like protein 3

1

9

High-throughput

0.479

High

1029254

NOS1
Nitric oxide synthase 1

1

6

High-throughput

0.479

High

1029256

HOME1
Homer protein homolog 1

1

6

High-throughput

0.479

High

147941

STXB1
Syntaxin-binding protein 1

1

0

High-throughput

0.458

High

604454

AP2A1
AP-2 complex subunit alpha-1

1

0

Small-scale

0.458

High

973663

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

1000049

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.458

High

1029198

CTNA2
Catenin alpha-2

1

0

High-throughput

0.458

High

609018

HS71B
Heat shock 70 kDa protein 1B

1

2

High-throughput

0.457

High

767010

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

12

High-throughput

0.457

High

312235

KLC2
Kinesin light chain 2

1

5

High-throughput

0.445

High

312898

BSN
Protein bassoon

1

1

High-throughput

0.445

High

811943

ZO1
Tight junction protein 1

1

20

High-throughput

0.445

High

858164

AINX
Alpha-internexin

1

4

High-throughput

0.445

High

943000

FUS
RNA-binding protein FUS

1

2

High-throughput

0.445

High

1029222

DLG1
Disks large homolog 1

1

20

High-throughput

0.445

High

1029235

DP13A
DCC-interacting protein 13-alpha

1

1

High-throughput

0.445

High

1029242

MYO5A
Unconventional myosin-Va

1

6

High-throughput

0.445

High

1029248

SRCN1
SRC kinase signaling inhibitor 1

1

4

High-throughput

0.445

High

107216

F8VQL0
Hepatocyte growth factor receptor

1

8

High-throughput

0.437

High

616117

KS6A3
Ribosomal protein S6 kinase alpha-3

1

10

High-throughput

0.437

High

866485

PA24A
Cytosolic phospholipase A2

1

7

High-throughput

0.437

High

1029193

CDKL5
Cyclin-dependent kinase-like 5

1

8

High-throughput

0.437

High

1029213

AKAP9
A-kinase anchor protein 9

1

9

High-throughput

0.437

High

1029224

DUS4
Dual specificity protein phosphatase 4

1

2

High-throughput

0.437

High

1029225

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

9

High-throughput

0.437

High

1029226

SHC2
SHC-transforming protein 2

1

18

Small-scale

0.437

High

1029231

SEPT8
Septin-8

1

3

High-throughput

0.437

High

1029240

UBAP2
Ubiquitin-associated protein 2

1

1

High-throughput

0.437

High

1029249

H2AY
Core histone macro-H2A.1

1

2

High-throughput

0.437

High

1029255

SEPT3
Neuronal-specific septin-3

1

3

High-throughput

0.437

High

553489

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

1

High-throughput

0.407

High

1000353

TP53B
TP53-binding protein 1

1

4

High-throughput

0.407

High

1029215

Q7TMX2
Protein phosphatase 2

1

2

High-throughput

0.407

High

1029233

Q8K2I5
Cltc protein

1

4

High-throughput

0.407

High

1029234

Q8K2R1
Fam171a1 protein

1

2

High-throughput

0.407

High

1029232

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025