Protein: PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-gamma-1) (PLC-gamma-1)

Gene: PLCG1
Organism: Mus musculus
Interactions: 28
UniProt ID: Q62077

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0001726 - ruffle
GO:0004435 - phosphatidylinositol-4,5-bisphosphate phospholipase C activity
GO:0004629 - phospholipase C activity
GO:0005085 - guanyl-nucleotide exchange factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

431953

PGFRB
Platelet-derived growth factor receptor beta

2

20

Small-scale

0.768

High

1221223

GRB2
Growth factor receptor-bound protein 2

2

17

Small-scale

0.737

High

1223511

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

5

Small-scale

0.724

High

581991

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.691

High

575631

EPOR
Erythropoietin receptor

1

7

Small-scale

0.690

High

778127

VGFR1
Vascular endothelial growth factor receptor 1

1

18

Small-scale

0.665

High

871459

LEPR
Leptin receptor

1

2

Small-scale

0.653

High

777825

VGFR2
Vascular endothelial growth factor receptor 2

1

17

Small-scale

0.625

High

236836

LAT
Linker for activation of T-cells family member 1

3

2

Small-scale

0.624

High

564873

NCAM1
Neural cell adhesion molecule 1

1

3

Small-scale

0.618

High

666042

TEC
Tyrosine-protein kinase Tec

1

17

Small-scale

0.618

High

1190020

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.618

High

1223508

SOS1
Son of sevenless homolog 1

1

6

Small-scale

0.618

High

1223513

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

3

Small-scale

0.618

High

1223515

STK11
Serine/threonine-protein kinase STK11

1

1

Small-scale

0.618

High

1189730

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.613

High

1223514

GAB1
GRB2-associated-binding protein 1

1

4

Small-scale

0.590

High

1221479

LCP2
Lymphocyte cytosolic protein 2

1

4

High-throughput

0.575

High

651535

CBL
E3 ubiquitin-protein ligase CBL

2

2

Small-scale

0.571

High

770698

CD22
B-cell receptor CD22

1

6

Small-scale

0.561

High

771477

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

3

High-throughput

0.536

High

478523

ITB1
Integrin beta-1

1

2

High-throughput

0.501

High

1021154

DAB1
Disabled homolog 1

1

2

Small-scale

0.479

High

1029201

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

3

High-throughput

0.479

High

1064911

RUNX2
Runt-related transcription factor 2

1

1

Small-scale

0.479

High

1223509

VILI
Villin-1

1

4

Small-scale

0.479

High

1223510

THMS1
Protein THEMIS

1

1

Small-scale

0.445

High

1223512

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.438

High


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Last updated: 11Aug2025