HitPredict

Interactor 1: SRC8 (Q14247)
Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Gene: CTTN

Interactor 2: SH24A (Q9H788)
SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)
Gene: SH2D4A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 550 Hs			1 454
+	Hs
		536590 HCLS1_HUMAN (1-550): 7.82e-141: 417: 37.50		SH24A_HUMAN (1-454): 1.2e-138: 407: 100.00
+	Hs
		561388 SRC8_HUMAN (1-550): 0: 559: 100.00		FER_HUMAN (147-445): 1.31e-41: 159: 16.99
+	Hs
		522981 SRC8_HUMAN (1-550): 0: 559: 100.00		SRC_HUMAN (238-454): 4.15e-42: 158: 14.56
+	Hs
		433350 SRC8_HUMAN (1-550): 0: 559: 100.00		YES_HUMAN (201-454): 1.68e-41: 156: 15.44
+	Hs
		924570 SRC8_HUMAN (1-550): 0: 559: 100.00		GRB2_HUMAN (310-454): 1.67e-42: 151: 24.83
+	Hs
		562646 SRC8_HUMAN (1-550): 0: 559: 100.00		PLCG2_HUMAN (98-454): 9.6e-30: 125: 15.11
+	Hs
		796571 SRC8_HUMAN (1-550): 0: 559: 100.00		KSYK_HUMAN (273-440): 2.84e-14: 76.8: 23.08
+	Rn
		71363 SRC8_RAT (1-550): 3.06e-174: 503: 84.91		B2RZ33_RAT (346-428): 2.78e-14: 76.1: 30.95
+	Mm
		411921 HCLS1_MOUSE (1-549): 1.3e-140: 417: 39.71		LCK_MOUSE (220-446): 1.68e-41: 156: 17.43
+	Hs
		536574 HCLS1_HUMAN (1-550): 7.82e-141: 417: 37.50		GRB2_HUMAN (310-454): 1.67e-42: 151: 24.83
+	Dm
		993202 Q9VDF4_DROME (1-549): 2.01e-135: 406: 40.81		GRAP_DROME (320-443): 2.94e-14: 73.4: 28.91
+	Hs
		522758 PLCG1_HUMAN (212-549): 1.13e-35: 144: 16.48		SRC_HUMAN (238-454): 4.15e-42: 158: 14.56
+	Rn
		499159 PLCG1_RAT (212-549): 1.06e-36: 147: 16.76		GRB2_RAT (310-454): 1.67e-42: 151: 24.83
+	Mm
		1141132 PLCG1_MOUSE (212-549): 3.02e-36: 146: 16.76		GRB2_MOUSE (310-454): 9.77e-43: 151: 24.83
+	Xl
		60960 A5LHG3_XENLA (212-549): 7.64e-37: 148: 17.60		GRB2A_XENLA (310-454): 2.23e-40: 146: 23.60
+	Rn
		499156 PLCG1_RAT (212-549): 1.06e-36: 147: 16.76		PLCG1_RAT (90-454): 3.67e-26: 114: 15.25
+	Bt
		439895 PLCG1_BOVIN (212-549): 3.82e-36: 146: 16.48		PLCG1_BOVIN (90-454): 2.39e-26: 114: 15.25
+	Hs
		580916 PLCG1_HUMAN (212-549): 1.13e-35: 144: 16.48		PLCG1_HUMAN (90-454): 1.69e-25: 112: 14.47
+	Hs
		580936 PLCG1_HUMAN (212-549): 1.13e-35: 144: 16.48		P85A_HUMAN (341-451): 2.42e-18: 90: 24.14
+	Hs
		580921 PLCG1_HUMAN (212-549): 1.13e-35: 144: 16.48		RASA1_HUMAN (347-453): 2.85e-13: 74.1: 25.44