Protein: GLYM
Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)

Gene: GLYM, SHM1
Organism: Saccharomyces cerevisiae S288C
Interactions: 155
UniProt ID: P37292

Gene Ontology (top 5):
GO:0004372 - glycine hydroxymethyltransferase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0006730 - one-carbon metabolic process
GO:0019264 - glycine biosynthetic process from serine

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

510409

HSP77
Import motor subunit, mitochondrial

2

2

High-throughput

0.584

High

790292

RQC1
Ribosome quality control complex subunit 1

2

1

Small-scale

0.584

High

790246

NACA
Nascent polypeptide-associated complex subunit alpha

2

1

High-throughput

0.571

High

790279

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

433587

RL26A
Large ribosomal subunit protein uL24A

2

1

High-throughput

0.533

High

455010

RS19A
Small ribosomal subunit protein eS19A

2

1

High-throughput

0.533

High

504166

RL31A
Large ribosomal subunit protein eL31A

2

1

High-throughput

0.533

High

689003

RL16A
Large ribosomal subunit protein uL13A

2

1

High-throughput

0.533

High

517996

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.501

High

392581

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.479

High

432547

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.479

High

433185

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.479

High

438671

SC160
Protein SCP160

1

1

High-throughput

0.479

High

626696

HSP60
Heat shock protein 60, mitochondrial

1

2

High-throughput

0.479

High

666440

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.479

High

670250

NAP1
Nucleosome assembly protein

1

1

Small-scale

0.479

High

674566

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

726948

HS104
Heat shock protein 104

1

3

Small-scale

0.479

High

739346

ZUO1
Zuotin

1

4

High-throughput

0.479

High

780592

CAB3
Coenzyme A biosynthesis protein 3

1

1

High-throughput

0.479

High

790245

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.479

High

790250

IF2P
Eukaryotic translation initiation factor 5B

1

2

High-throughput

0.479

High

790257

TM108
Protein TMA108

1

2

High-throughput

0.479

High

790269

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.479

High

790273

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

790275

JJJ1
J protein JJJ1

1

1

High-throughput

0.479

High

790276

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

790282

ABF2
ARS-binding factor 2, mitochondrial

1

2

High-throughput

0.479

High

790285

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

790288

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

790300

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

790301

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.479

High

149710

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

383291

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.458

High

399821

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

0

High-throughput

0.458

High

415010

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.458

High

427229

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.458

High

434247

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

435910

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

482000

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.458

High

514591

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

569758

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

569976

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

647085

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

684690

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

746808

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

778273

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

780893

YKH1
Uncharacterized oxidoreductase YKL071W

1

0

High-throughput

0.458

High

781358

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

790240

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.458

High

790242

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

790243

EFM1
Protein-lysine N-methyltransferase EFM1

1

0

High-throughput

0.458

High

790247

STM1
Suppressor protein STM1

1

0

High-throughput

0.458

High

790249

ECM1
Shuttling pre-60S factor ECM1

1

0

High-throughput

0.458

High

790253

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

790256

YIQ1
Uncharacterized protein YIL161W

1

0

High-throughput

0.458

High

790260

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.458

High

790262

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

790266

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

790268

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.458

High

790280

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

790283

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

0

High-throughput

0.458

High

790289

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

790291

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

790296

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

790297

SGO1
Shugoshin

1

0

High-throughput

0.458

High

790303

RQC2
Ribosome quality control complex subunit 2

1

0

High-throughput

0.458

High

523664

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

526449

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

544537

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

741394

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

790254

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

790293

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

7

High-throughput

0.445

High

154154

RL36B
Large ribosomal subunit protein eL36B

1

1

High-throughput

0.437

High

383114

RLA4
Large ribosomal subunit protein P2B

1

1

High-throughput

0.437

High

409717

RL24A
Large ribosomal subunit protein eL24A

1

1

High-throughput

0.437

High

427560

RLA1
Large ribosomal subunit protein P1A

1

1

High-throughput

0.437

High

427688

RLA2
Large ribosomal subunit protein P2A

1

1

High-throughput

0.437

High

432827

RL9A
Large ribosomal subunit protein uL6A

1

1

High-throughput

0.437

High

433007

RL6B
Large ribosomal subunit protein eL6B

1

1

High-throughput

0.437

High

434000

RL33A
Large ribosomal subunit protein eL33A

1

1

High-throughput

0.437

High

434151

RL36A
Large ribosomal subunit protein eL36A

1

1

High-throughput

0.437

High

434547

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.437

High

441855

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

455396

RS19B
Small ribosomal subunit protein eS19B

1

1

High-throughput

0.437

High

503377

RL11A
Large ribosomal subunit protein uL5A

1

1

High-throughput

0.437

High

504522

RL31B
Large ribosomal subunit protein eL31B

1

1

High-throughput

0.437

High

528811

RLA3
Large ribosomal subunit protein P1B

1

1

High-throughput

0.437

High

531694

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.437

High

567678

ACOX
Acyl-coenzyme A oxidase

1

1

High-throughput

0.437

High

601022

RL8A
Large ribosomal subunit protein eL8A

1

1

High-throughput

0.437

High

663667

RL24B
Large ribosomal subunit protein eL24B

1

1

High-throughput

0.437

High

670587

SIS1
Protein SIS1

1

2

High-throughput

0.437

High

689197

RL16B
Large ribosomal subunit protein uL13B

1

1

High-throughput

0.437

High

689398

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

706840

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

708718

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.437

High

712543

RL8B
Large ribosomal subunit protein eL8B

1

1

High-throughput

0.437

High

747310

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

779828

SIS2
Phosphopantothenoylcysteine decarboxylase subunit SIS2

1

1

High-throughput

0.437

High

781168

RL14A
Large ribosomal subunit protein eL14A

1

1

High-throughput

0.437

High

790241

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

790244

RL14B
Large ribosomal subunit protein eL14B

1

1

High-throughput

0.437

High

790248

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

790255

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.437

High

790258

RL34B
Large ribosomal subunit protein eL34B

1

1

High-throughput

0.437

High

790261

RL33B
Large ribosomal subunit protein eL33B

1

1

High-throughput

0.437

High

790263

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.437

High

790264

RL17B
Large ribosomal subunit protein uL22B

1

1

High-throughput

0.437

High

790265

RS7B
Small ribosomal subunit protein eS7B

1

1

High-throughput

0.437

High

790267

RL37A
Large ribosomal subunit protein eL37A

1

1

High-throughput

0.437

High

790270

RL9B
Large ribosomal subunit protein uL6B

1

1

High-throughput

0.437

High

790271

RL37B
Large ribosomal subunit protein eL37B

1

1

High-throughput

0.437

High

790272

RL26B
Large ribosomal subunit protein uL24B

1

1

High-throughput

0.437

High

790277

RL22B
Large ribosomal subunit protein eL22B

1

1

High-throughput

0.437

High

790278

RL34A
Large ribosomal subunit protein eL34A

1

1

High-throughput

0.437

High

790281

RL6A
Large ribosomal subunit protein eL6A

1

1

High-throughput

0.437

High

790284

RL21A
Large ribosomal subunit protein eL21A

1

1

High-throughput

0.437

High

790290

POB3
FACT complex subunit POB3

1

1

High-throughput

0.437

High

790294

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

790295

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

790298

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

790299

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

790302

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

790304

RL21B
Large ribosomal subunit protein eL21B

1

1

High-throughput

0.437

High

790305

RL13A
Large ribosomal subunit protein eL13A

1

1

High-throughput

0.437

High

790306

RL11B
Large ribosomal subunit protein uL5B

1

1

High-throughput

0.437

High

790286

GCN5
Histone acetyltransferase GCN5

1

1

High-throughput

0.407

High

513670

RL2A
Large ribosomal subunit protein uL2A

3

0

High-throughput

0.334

High

383649

RS17A
Small ribosomal subunit protein eS17A

2

0

High-throughput

0.305

High

410071

RL25
Large ribosomal subunit protein uL23

2

0

High-throughput

0.305

High

512389

RS6A
Small ribosomal subunit protein eS6A

2

0

High-throughput

0.305

High

753314

RS3A1
Small ribosomal subunit protein eS1A

2

0

High-throughput

0.305

High

381074

H2B1
Histone H2B.1

1

0

High-throughput

0.249

Low

434354

RL15A
Large ribosomal subunit protein eL15A

1

0

High-throughput

0.249

Low

502991

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

503909

RL27B
Large ribosomal subunit protein eL27B

1

0

High-throughput

0.249

Low

511174

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

511401

RL43B
Large ribosomal subunit protein eL43B

1

0

High-throughput

0.249

Low

512956

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

513485

RL1A
Large ribosomal subunit protein uL1A

1

0

High-throughput

0.249

Low

513981

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.249

Low

514267

RL12B
Large ribosomal subunit protein uL11B

1

0

High-throughput

0.249

Low

515080

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

515242

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

515364

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.249

Low

553531

PDR1
Transcription factor PDR1

1

0

High-throughput

0.249

Low

677357

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

736635

ASF1
Histone chaperone ASF1

1

0

Small-scale

0.249

Low

739603

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

790251

RS26A
Small ribosomal subunit protein eS26A

1

0

High-throughput

0.249

Low

790252

THO1
Protein THO1

1

0

High-throughput

0.249

Low

790259

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

790274

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

790287

YMB8
Uncharacterized vacuolar membrane protein YML018C

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025