HitPredict

Interactor 1: TRI25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Gene: TRIM25

Interactor 2: SIR6 (Q8N6T7)
NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6)
Gene: SIRT6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24169447, 34244565
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 630 Hs			1 355
+	Hs
		1052781 TRI25_HUMAN (1-630): 3.52e-149: 447: 100.00		SIR7_HUMAN (22-321): 2.13e-101: 306: 38.61
+	Hs
		536928 TRI27_HUMAN (2-358): 2.11e-31: 130: 14.40		SIR6_HUMAN (1-355): 2.25e-166: 469: 100.00
+	Hs
		1171186 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		SIR1_HUMAN (25-336): 3.35e-99: 311: 21.83
+	Hs
		1171907 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		SIR3_HUMAN (33-287): 6.34e-90: 276: 27.92
+	Hs
		1171988 TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73		SIR5_HUMAN (22-264): 6.55e-77: 240: 19.20
+	Mm
		1112451 Q3UCL2_MOUSE (3-264): 2.89e-30: 126: 18.32		SIR5_MOUSE (21-264): 3.46e-77: 241: 19.86
+	Hs
		585082 RO52_HUMAN (72-325): 5.42e-14: 76.6: 13.36		SIR5_HUMAN (22-264): 6.55e-77: 240: 19.20