HitPredict

Interactor 1: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Interactor 2: MYPC3 (Q14896)
Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)
Gene: MYBPC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	21569246
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~fn3
Common GO terms	GO:0005829 - cytosol GO:0045214 - sarcomere organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2725 Hs			1 1274
+	Hs
		1052875 FLNC_HUMAN (1-2725): 0: 2507: 100.00		MYPC2_HUMAN (6-772): 6.84e-40: 163: 13.37
+	Hs
		255772 FLNC_HUMAN (1-2725): 0: 2507: 100.00		OBSL1_HUMAN (15-95): 7.76e-12: 72.6: 34.57
+	Hs
		261263 FLNB_HUMAN (146-2725): 0: 1198: 35.18		MYPC2_HUMAN (6-772): 6.84e-40: 163: 13.37
+	Hs
		234453 FLNB_HUMAN (146-2725): 0: 1198: 35.18		DSCAM_HUMAN (970-1273): 1.84e-22: 107: 18.04
+	Hs
		255501 FLNA_HUMAN (167-2725): 0: 1226: 35.27		OBSL1_HUMAN (15-95): 7.76e-12: 72.6: 34.57
+	Hs
		598253 FLNA_HUMAN (167-2725): 0: 1226: 35.27		TITIN_HUMAN (785-1011): 8.33e-11: 69.1: 10.29
+	Mm
		1161055 FLNB_MOUSE (146-2725): 0: 1194: 34.74		MYLK_MOUSE (1149-1270): 3.57e-14: 80: 24.59
+	Hs
		255374 FLNB_HUMAN (146-2725): 0: 1198: 35.18		OBSL1_HUMAN (15-95): 7.76e-12: 72.6: 34.57
+	Dm
		1337379 FLNA_DROME (758-2724): 0: 1012: 33.19		TITIN_DROME (1109-1273): 4.41e-15: 83.4: 24.10
+	Hs
		725655 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		MYPC2_HUMAN (6-772): 6.84e-40: 163: 13.37
+	Hs
		234468 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		DSCAM_HUMAN (970-1273): 1.84e-22: 107: 18.04
+	Hs
		211436 ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68		DSCAM_HUMAN (970-1273): 1.84e-22: 107: 18.04
+	Hs
		725635 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		MYOM2_HUMAN (771-1164): 8.65e-18: 91.7: 24.94
+	Hs
		255470 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		OBSL1_HUMAN (15-95): 7.76e-12: 72.6: 34.57
+	Hs
		521586 ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30		TITIN_HUMAN (785-1011): 8.33e-11: 69.1: 10.29
+	Hs
		725681 ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00		TITIN_HUMAN (785-1011): 8.33e-11: 69.1: 10.29
+	Hs
		211438 ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68		OBSL1_HUMAN (15-95): 7.76e-12: 72.6: 34.57
+	Hs
		211629 ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68		TITIN_HUMAN (785-1011): 8.33e-11: 69.1: 10.29
+	Hs
		993278 ACTN3_HUMAN (23-388): 4.53e-120: 406: 27.63		TITIN_HUMAN (785-1011): 8.33e-11: 69.1: 10.29
+	Hs
		234502 SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12		DSCAM_HUMAN (970-1273): 1.84e-22: 107: 18.04