HitPredict

Interactor 1: FKBP8 (Q14318)
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
Gene: FKBP8

Interactor 2: NEK11 (Q8NG66)
Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11)
Gene: NEK11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0035556 - intracellular signal transduction GO:0046872 - metal ion binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 412 Hs			1 645
+	Hs
		1053253 FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00		KCC2A_HUMAN (17-470): 5.16e-122: 372: 20.56
+	Hs
		1034935 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		NEK11_HUMAN (1-645): 3.65e-171: 504: 100.00
+	Hs
		1034842 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		KCC2G_HUMAN (18-560): 4.11e-135: 409: 17.79
+	Hs
		1034968 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		MARK4_HUMAN (6-593): 1.67e-130: 403: 16.80
+	Hs
		682173 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		AKT2_HUMAN (4-359): 1.82e-132: 399: 19.06
+	Hs
		1035058 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		AKT3_HUMAN (5-359): 1.01e-131: 397: 21.33
+	Hs
		681830 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		AKT1_HUMAN (4-354): 4.58e-128: 387: 19.83
+	Hs
		684698 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		KCC2D_HUMAN (18-435): 1.16e-123: 377: 19.77
+	Hs
		1034843 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		KCC2D_HUMAN (18-435): 1.16e-123: 377: 19.77
+	Hs
		118758 AIP_HUMAN (97-369): 4.45e-54: 184: 18.94		NEK8_HUMAN (28-294): 5.75e-47: 178: 36.06
+	Hs
		851484 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		NEK4_HUMAN (29-291): 4.98e-61: 220: 43.02
+	Hs
		972538 FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18		NEK8_HUMAN (28-294): 5.75e-47: 178: 36.06
+	Hs
		972555 FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18		NEK7_HUMAN (29-284): 1.32e-46: 168: 34.35
+	Hs
		684848 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		NEK8_HUMAN (28-294): 5.75e-47: 178: 36.06
+	Hs
		684908 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		NEK9_HUMAN (29-294): 1.53e-40: 160: 34.20
+	Hs
		972532 FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18		NEK10_HUMAN (29-306): 9.52e-31: 130: 30.87
+	Hs
		684829 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		NEK10_HUMAN (29-306): 9.52e-31: 130: 30.87