HitPredict

Interactor 1: FKBP8 (Q14318)
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
Gene: FKBP8

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 412 Hs			1 1731
+	Mm
		192800 FKBP8_MOUSE (1-412): 7.85e-99: 302: 90.78		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Hs
		883512 FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00		RIPK4_HUMAN (25-420): 3.28e-78: 280: 16.00
+	Hs
		556701 FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00		ANK1_HUMAN (175-527): 4.16e-38: 159: 17.28
+	Hs
		883470 FKB1A_HUMAN (101-204): 1.72e-35: 128: 32.41		RIPK4_HUMAN (25-420): 3.28e-78: 280: 16.00
+	Hs
		883489 FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18		RIPK4_HUMAN (25-420): 3.28e-78: 280: 16.00
+	Hs
		684571 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		RIPK4_HUMAN (25-420): 3.28e-78: 280: 16.00
+	Hs
		1053188 FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00		Q9H4D1_HUMAN (275-465): 9.3e-09: 62.6: 15.39
+	Hs
		883504 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		RIPK4_HUMAN (25-420): 3.28e-78: 280: 16.00
+	Hs
		684893 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		ANKK1_HUMAN (185-523): 7.1e-51: 196: 20.06
+	Hs
		1034933 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		ANKK1_HUMAN (185-523): 7.1e-51: 196: 20.06
+	Hs
		923838 FKB1A_HUMAN (101-204): 1.72e-35: 128: 32.41		Q9H4D1_HUMAN (275-465): 9.3e-09: 62.6: 15.39
+	Hs
		972586 FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18		Q9H4D1_HUMAN (275-465): 9.3e-09: 62.6: 15.39
+	Hs
		685027 STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00		Q9H4D1_HUMAN (275-465): 9.3e-09: 62.6: 15.39
+	Hs
		1034995 FKBP5_HUMAN (72-203): 1.44e-18: 89.2: 27.21		Q9H4D1_HUMAN (275-465): 9.3e-09: 62.6: 15.39