HitPredict

Interactor 1: CASL (Q14511)
Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]
Gene: NEDD9

Interactor 2: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.600

Property	Details
Experiments	11118211, 15231748
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 834 Hs			1 465
+	Hs
		950182 CASL_HUMAN (1-834): 0: 614: 100.00		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Hs
		1054769 CASL_HUMAN (1-834): 0: 614: 100.00		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Hs
		171379 BCAR1_HUMAN (1-832): 3e-84: 289: 33.44		SMAD9_HUMAN (3-465): 0: 607: 81.29
+	Hs
		171390 DYST_HUMAN (403-825): 1.13e-34: 146: 11.63		SMAD9_HUMAN (3-465): 0: 607: 81.29
+	Hs
		1078590 KMT2C_HUMAN (137-685): 7.85e-10: 65.2: 8.48		SMAD2_HUMAN (3-465): 0: 541: 55.14