HitPredict

Interactor 1: CASL (Q14511)
Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]
Gene: NEDD9

Interactor 2: SH2D3 (Q8N5H7)
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)
Gene: SH2D3C

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10692442
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CAS_C~RasGEF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 834 Hs			1 860
+	Mm
		192350 CASL_MOUSE (1-834): 0: 612: 88.85		SH2D3_MOUSE (1-860): 0: 851: 86.40
+	Hs
		275570 CASL_HUMAN (1-834): 0: 614: 100.00		BCAR3_HUMAN (55-860): 0: 715: 39.09
+	Hs
		275559 BCAR1_HUMAN (1-832): 3e-84: 289: 33.44		BCAR3_HUMAN (55-860): 0: 715: 39.09
+	Dm
		1182672 Q7KVE5_DROME (6-830): 5.8e-109: 354: 23.00		Q9VMJ4_DROME (44-851): 0: 605: 28.05
+	Dm
		60027 A4IJ58_DROME (3-830): 1.72e-98: 327: 22.92		Q8T9B3_DROME (44-851): 0: 607: 28.05
+	Dm
		60037 A4IJ58_DROME (3-830): 1.72e-98: 327: 22.92		Q9VMJ4_DROME (44-851): 0: 605: 28.05
+	Hs
		412193 CASL_HUMAN (1-834): 0: 614: 100.00		FYN_HUMAN (82-423): 9e-64: 225: 10.99
+	Hs
		433761 CASL_HUMAN (1-834): 0: 614: 100.00		LYN_HUMAN (132-424): 2.93e-54: 198: 11.39
+	Hs
		411721 CASL_HUMAN (1-834): 0: 614: 100.00		LCK_HUMAN (123-424): 1.07e-53: 196: 10.59
+	Hs
		802600 CASL_HUMAN (1-834): 0: 614: 100.00		CRK_HUMAN (209-512): 9.59e-54: 190: 16.06
+	Mm
		192348 CASL_MOUSE (1-834): 0: 612: 88.85		CRK_MOUSE (209-512): 1.83e-53: 190: 16.06
+	Hs
		802843 CASL_HUMAN (1-834): 0: 614: 100.00		CRKL_HUMAN (220-480): 2.1e-51: 184: 18.12
+	Hs
		412110 BCAR1_HUMAN (1-832): 3e-84: 289: 33.44		FYN_HUMAN (82-423): 9e-64: 225: 10.99
+	Hs
		433301 BCAR1_HUMAN (1-832): 3e-84: 289: 33.44		YES_HUMAN (81-393): 4.07e-61: 218: 11.78
+	Hs
		434078 MACF1_HUMAN (475-828): 1.25e-87: 307: 13.06		LYN_HUMAN (132-424): 2.93e-54: 198: 11.39
+	Hs
		411889 MACF1_HUMAN (475-828): 1.25e-87: 307: 13.06		LCK_HUMAN (123-424): 1.07e-53: 196: 10.59
+	Hs
		433668 BCAR1_HUMAN (1-832): 3e-84: 289: 33.44		LYN_HUMAN (132-424): 2.93e-54: 198: 11.39
+	Hs
		442799 BCAR1_HUMAN (1-832): 3e-84: 289: 33.44		HCK_HUMAN (91-394): 1.07e-53: 197: 13.71
+	Hs
		411655 BCAR1_HUMAN (1-832): 3e-84: 289: 33.44		LCK_HUMAN (123-424): 1.07e-53: 196: 10.59
+	Hs
		209020 BCAR1_HUMAN (1-832): 3e-84: 289: 33.44		NCK2_HUMAN (98-309): 6.4e-23: 103: 18.72