Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1
Interactor 2: TOPB1 (Q92547)
DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)
Gene: TOPBP1
Species: Homo sapiens
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.89 | 1.00 | 0.949 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 29656893, 27590578, 30898438, 23891287, 21482717, 24239288 |
| Identification Methods | proximity labelling technology, affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, pull down |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | BRCT~BRCT_2 |
| Common GO terms | GO:0000076 - DNA replication checkpoint signaling GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome GO:0006281 - DNA repair and 5 others more... |
| Homologous interactions | 14 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
