HitPredict

Interactor 1: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Interactor 2: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29656893
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0060261 - positive regulation of transcription initiation by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2089 Hs			1 2177
+	Hs
		1019059 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		MED12_HUMAN (1-2177): 0: 2488: 100.00
+	Hs
		801287 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		MED12_HUMAN (1-2177): 0: 2488: 100.00
+	Hs
		1056974 MDC1_HUMAN (1-2089): 0: 665: 100.00		WDR33_HUMAN (1594-2167): 1.1e-24: 115: 8.81
+	Hs
		1056910 MDC1_HUMAN (1-2089): 0: 665: 100.00		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		1056953 MDC1_HUMAN (1-2089): 0: 665: 100.00		ATX2_HUMAN (1645-2176): 2.64e-11: 71.5: 9.32
+	Hs
		1056898 MDC1_HUMAN (1-2089): 0: 665: 100.00		ARI1B_HUMAN (1839-2172): 5.1e-10: 67.3: 14.20
+	Mm
		936732 TP53B_MOUSE (181-1970): 1.84e-92: 337: 10.07		MDC1_MOUSE (1602-2174): 1.94e-09: 65.3: 11.15
+	Mm
		99861 TP53B_MOUSE (181-1970): 1.84e-92: 337: 10.07		F6M2J9_MOUSE (1841-2175): 8.77e-09: 63: 13.27
+	Hs
		1019050 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		1270850 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		1019030 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		ARI1B_HUMAN (1839-2172): 5.1e-10: 67.3: 14.20
+	Hs
		1018957 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		NCOA6_HUMAN (1716-2173): 1.71e-09: 65.7: 11.91
+	Hs
		801346 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		DIDO1_HUMAN (1479-2099): 1.5e-18: 95.4: 10.74
+	Hs
		1019084 TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87		EP400_HUMAN (1812-2174): 7.89e-09: 63.4: 17.63
+	Hs
		1057810 NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36		NCOA6_HUMAN (1716-2173): 1.71e-09: 65.7: 11.91
+	Hs
		1173233 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		WDR33_HUMAN (1594-2167): 1.1e-24: 115: 8.81
+	Hs
		801437 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		CHD7_HUMAN (1825-2174): 2.18e-10: 68.8: 10.05
+	Hs
		801312 KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53		EP400_HUMAN (1812-2174): 7.89e-09: 63.4: 17.63
+	Hs
		1173188 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		KMT2C_HUMAN (1619-2174): 8.59e-16: 86.5: 10.80
+	Hs
		1057766 PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56		NCOA6_HUMAN (1716-2173): 1.71e-09: 65.7: 11.91