Protein: SNX6
Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed]

Gene: SNX6
Organism: Homo sapiens
Interactions: 197
UniProt ID: Q9UNH7

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0005768 - endosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1111994

SNX1
Sorting nexin-1

9

19

Small-scale

0.973

High

255500

SNX2
Sorting nexin-2

7

19

Small-scale

0.963

High

1462313

DYN3
Dynamin-3

3

13

High-throughput

0.861

High

1293581

SNX32
Sorting nexin-32

2

15

High-throughput

0.811

High

1430556

TSYL1
Testis-specific Y-encoded-like protein 1

4

1

High-throughput

0.697

High

333257

VAPB
Vesicle-associated membrane protein-associated protein B/C

4

3

High-throughput

0.691

High

1448558

DISC1
Disrupted in schizophrenia 1 protein

4

4

High-throughput

0.688

High

967186

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

3

2

High-throughput

0.667

High

1279513

CMKMT
Calmodulin-lysine N-methyltransferase

3

2

High-throughput

0.667

High

1332680

CAST3
Putative protein CASTOR3P

3

1

High-throughput

0.667

High

541066

PIM1
Serine/threonine-protein kinase pim-1

2

6

Small-scale

0.631

High

1214627

HENMT
Small RNA 2'-O-methyltransferase

2

1

High-throughput

0.628

High

1358223

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

1

High-throughput

0.628

High

1359058

DYT2B
Dynein light chain Tctex-type protein 2B

2

1

High-throughput

0.628

High

1395787

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

2

High-throughput

0.628

High

329867

SNX4
Sorting nexin-4

1

18

Small-scale

0.618

High

1396864

SNX27
Sorting nexin-27

1

4

High-throughput

0.618

High

1434229

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.618

High

1462312

SNX7
Sorting nexin-7

1

19

Small-scale

0.618

High

1123872

DCTN1
Dynactin subunit 1

2

1

Small-scale

0.611

High

61859

F221A
Protein FAM221A

3

2

High-throughput

0.609

High

1212112

TRML2
Trem-like transcript 2 protein

3

1

High-throughput

0.609

High

1428218

NDEL1
Nuclear distribution protein nudE-like 1

2

1

High-throughput

0.590

High

218960

TGON2
Trans-Golgi network integral membrane protein 2

2

8

High-throughput

0.588

High

1150225

TEAD4
Transcriptional enhancer factor TEF-3

2

0

High-throughput

0.585

High

243291

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

540753

LAMP1
Lysosome-associated membrane glycoprotein 1

2

15

High-throughput

0.584

High

631020

RAB4A
Ras-related protein Rab-4A

2

13

High-throughput

0.584

High

902142

RAB9A
Ras-related protein Rab-9A

2

17

High-throughput

0.584

High

976664

RB11A
Ras-related protein Rab-11A

2

9

High-throughput

0.584

High

1461050

TNIK
TRAF2 and NCK-interacting protein kinase

2

5

High-throughput

0.576

High

1462314

GAB2
GRB2-associated-binding protein 2

1

5

High-throughput

0.575

High

387921

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

1

High-throughput

0.574

High

1114655

CUL3
Cullin-3

1

3

Small-scale

0.561

High

898885

RL14
Large ribosomal subunit protein eL14

2

0

High-throughput

0.559

High

1315007

TEX11
Testis-expressed protein 11

2

2

High-throughput

0.553

High

625703

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.541

High

1154198

ITSN1
Intersectin-1

1

5

High-throughput

0.541

High

1386629

OPTN
Optineurin

1

5

High-throughput

0.541

High

571693

HCLS1
Hematopoietic lineage cell-specific protein

1

9

High-throughput

0.536

High

904413

BRCA2
Breast cancer type 2 susceptibility protein

1

1

High-throughput

0.536

High

933548

S12A3
Solute carrier family 12 member 3

1

3

High-throughput

0.536

High

1153233

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

4

High-throughput

0.536

High

1228741

C102B
Coiled-coil domain-containing protein 102B

1

3

High-throughput

0.536

High

1252017

STAC2
SH3 and cysteine-rich domain-containing protein 2

1

18

High-throughput

0.536

High

1309289

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

2

High-throughput

0.536

High

1357358

PRUN2
Protein prune homolog 2

1

2

High-throughput

0.536

High

1407018

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.536

High

1413112

INP5K
Inositol polyphosphate 5-phosphatase K

1

5

High-throughput

0.536

High

1434621

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

6

High-throughput

0.536

High

1447702

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

2

High-throughput

0.536

High

1448016

KLHL1
Kelch-like protein 1

1

4

High-throughput

0.536

High

1460138

NRBP
Nuclear receptor-binding protein

1

3

High-throughput

0.536

High

1462030

SPAT2
Spermatogenesis-associated protein 2

1

1

High-throughput

0.536

High

1462316

NTNG1
Netrin-G1

1

6

High-throughput

0.536

High

164474

NRP1
Neuropilin-1

1

5

High-throughput

0.527

High

1439496

BRMS1
Breast cancer metastasis-suppressor 1

1

0

Small-scale

0.526

High

1351614

MIPT3
TRAF3-interacting protein 1

2

1

High-throughput

0.516

High

390810

TFR1
Transferrin receptor protein 1

1

3

High-throughput

0.515

High

423458

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.515

High

322478

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.513

High

997186

TBA4A
Tubulin alpha-4A chain

1

0

High-throughput

0.513

High

1101097

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

1102293

ATM
Serine-protein kinase ATM

1

0

High-throughput

0.513

High

1361657

ATG4A
Cysteine protease ATG4A

1

0

High-throughput

0.513

High

1395041

SPTCS
Spatacsin

1

0

High-throughput

0.513

High

1462318

MTCL1
Microtubule cross-linking factor 1

1

0

High-throughput

0.513

High

49176

POTB3
POTE ankyrin domain family member B3

2

5

High-throughput

0.504

High

186121

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

High-throughput

0.501

High

397219

ESR1
Estrogen receptor

1

3

Small-scale

0.501

High

191981

TEX28
Testis-specific protein TEX28

1

1

High-throughput

0.489

High

643201

BMP6
Bone morphogenetic protein 6

1

3

High-throughput

0.489

High

1181035

DB136
Defensin beta 136

1

3

High-throughput

0.489

High

1292696

TMPSC
Transmembrane protease serine 12

1

4

High-throughput

0.489

High

1360058

IBPL1
Insulin-like growth factor-binding protein-like 1

1

7

High-throughput

0.489

High

1462319

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.489

High

800170

COIL
Coilin

1

0

High-throughput

0.486

High

799575

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.481

High

942363

BACE1
Beta-secretase 1

1

0

Small-scale

0.479

High

124665

EYA2
Protein phosphatase EYA2

1

2

High-throughput

0.479

High

159922

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

3

High-throughput

0.479

High

164130

NDC80
Kinetochore protein NDC80 homolog

1

1

High-throughput

0.479

High

189927

STX7
Syntaxin-7

1

7

High-throughput

0.479

High

226262

STX6
Syntaxin-6

1

3

High-throughput

0.479

High

249067

NRP2
Neuropilin-2

1

5

High-throughput

0.479

High

274807

DNJB6
DnaJ homolog subfamily B member 6

1

4

High-throughput

0.479

High

317693

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.479

High

343107

HERC2
E3 ubiquitin-protein ligase HERC2

1

4

High-throughput

0.479

High

364026

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.479

High

374282

RASN
GTPase NRas

1

19

High-throughput

0.479

High

375016

RASH
GTPase HRas

1

16

High-throughput

0.479

High

376096

RASK
GTPase KRas

1

19

High-throughput

0.479

High

400041

CATA
Catalase

1

1

High-throughput

0.479

High

439880

INSR
Insulin receptor

1

20

Small-scale

0.479

High

440242

LCK
Tyrosine-protein kinase Lck

1

13

High-throughput

0.479

High

446086

ENOA
Alpha-enolase

1

1

High-throughput

0.479

High

459801

PROF1
Profilin-1

1

1

High-throughput

0.479

High

465694

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.479

High

538117

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

541756

FGFR1
Fibroblast growth factor receptor 1

1

14

High-throughput

0.479

High

548645

MPRI
Cation-independent mannose-6-phosphate receptor

1

2

High-throughput

0.479

High

562490

LAMP2
Lysosome-associated membrane glycoprotein 2

1

15

High-throughput

0.479

High

583025

EZRI
Ezrin

1

1

High-throughput

0.479

High

593539

PGFRA
Platelet-derived growth factor receptor alpha

1

15

Small-scale

0.479

High

604271

CXA1
Gap junction alpha-1 protein

1

2

High-throughput

0.479

High

605849

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

3

High-throughput

0.479

High

607224

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

631562

RAB5A
Ras-related protein Rab-5A

1

14

High-throughput

0.479

High

679414

DNJB2
DnaJ homolog subfamily B member 2

1

7

High-throughput

0.479

High

715846

MARCS
Myristoylated alanine-rich C-kinase substrate

1

5

High-throughput

0.479

High

777794

VGFR3
Vascular endothelial growth factor receptor 3

1

16

High-throughput

0.479

High

787468

TGFR1
TGF-beta receptor type-1

1

8

Small-scale

0.479

High

789040

TGFR2
TGF-beta receptor type-2

1

8

Small-scale

0.479

High

833389

PERI
Peripherin

1

2

High-throughput

0.479

High

901105

RAB5C
Ras-related protein Rab-5C

1

14

High-throughput

0.479

High

975321

ARF6
ADP-ribosylation factor 6

1

6

High-throughput

0.479

High

978405

RHOB
Rho-related GTP-binding protein RhoB

1

6

High-throughput

0.479

High

1004238

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.479

High

1107679

MTM1
Myotubularin

1

4

High-throughput

0.479

High

1116852

AVR2B
Activin receptor type-2B

1

8

Small-scale

0.479

High

1130882

RRP5
Protein RRP5 homolog

1

3

High-throughput

0.479

High

1144557

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

1

High-throughput

0.479

High

1145173

RAB35
Ras-related protein Rab-35

1

7

High-throughput

0.479

High

1157113

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.479

High

1159050

RBBP7
Histone-binding protein RBBP7

1

3

High-throughput

0.479

High

1218040

MYOME
Myomegalin

1

1

High-throughput

0.479

High

1233578

LTOR1
Ragulator complex protein LAMTOR1

1

8

High-throughput

0.479

High

1256091

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1276371

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

1276966

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1334063

DHB11
Estradiol 17-beta-dehydrogenase 11

1

1

High-throughput

0.479

High

1334626

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

1364689

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1383711

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.479

High

1402451

CCNL2
Cyclin-L2

1

2

High-throughput

0.479

High

1406089

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

1415082

LRC61
Leucine-rich repeat-containing protein 61

1

2

High-throughput

0.479

High

1433005

DNJC5
DnaJ homolog subfamily C member 5

1

11

High-throughput

0.479

High

1449772

ZDH18
Palmitoyltransferase ZDHHC18

1

2

Small-scale

0.479

High

1454183

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

5

High-throughput

0.479

High

1454799

ANFY1
Rabankyrin-5

1

6

High-throughput

0.479

High

1459076

DNJ5B
DnaJ homolog subfamily C member 5B

1

11

High-throughput

0.479

High

1459311

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1461749

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

2

High-throughput

0.479

High

1462265

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

High-throughput

0.479

High

1462315

LAMP3
Lysosome-associated membrane glycoprotein 3

1

15

High-throughput

0.479

High

1462317

GIT1
ARF GTPase-activating protein GIT1

1

3

Small-scale

0.479

High

244792

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.458

High

299430

FLOT1
Flotillin-1

1

0

High-throughput

0.458

High

327499

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

1032564

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

High-throughput

0.458

High

1128866

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

1161758

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1323552

ZN687
Zinc finger protein 687

1

0

High-throughput

0.458

High

1384905

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1429887

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1057046

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.457

High

409540

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.445

High

430505

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

530582

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

1227708

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.445

High

1330844

TSYL6
Testis-specific Y-encoded-like protein 6

1

1

High-throughput

0.445

High

128544

BMR1B
Bone morphogenetic protein receptor type-1B

1

8

Small-scale

0.437

High

180104

BET1
BET1 homolog

1

3

High-throughput

0.437

High

228763

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

2

High-throughput

0.437

High

341172

DIRA3
GTP-binding protein Di-Ras3

1

6

High-throughput

0.437

High

451463

NFM
Neurofilament medium polypeptide

1

2

High-throughput

0.437

High

464080

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

18

High-throughput

0.437

High

488891

FURIN
Furin

1

1

High-throughput

0.437

High

769508

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

788468

ACVL1
Activin receptor type-1-like

1

8

Small-scale

0.437

High

845861

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.437

High

871492

LEPR
Leptin receptor

1

4

Small-scale

0.437

High

931916

EPHA5
Ephrin type-A receptor 5

1

18

High-throughput

0.437

High

945121

RAB25
Ras-related protein Rab-25

1

11

High-throughput

0.437

High

1159906

OCLN
Occludin

1

2

High-throughput

0.437

High

1206575

PRC2B
Protein PRRC2B

1

3

High-throughput

0.437

High

1315332

ZDH23
Palmitoyltransferase ZDHHC23

1

5

Small-scale

0.437

High

1324515

FA43A
Protein FAM43A

1

2

High-throughput

0.437

High

1382005

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1410917

GORS1
Golgi reassembly-stacking protein 1

1

1

High-throughput

0.437

High

1431791

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

2

High-throughput

0.437

High

1433579

RHOJ
Rho-related GTP-binding protein RhoJ

1

8

High-throughput

0.437

High

1452726

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.437

High

1454085

SEP10
Septin-10

1

1

High-throughput

0.437

High

1461996

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.437

High

1104165

RM49
Large ribosomal subunit protein mL49

1

3

High-throughput

0.407

High

1253681

PKHG7
Pleckstrin homology domain-containing family G member 7

1

2

High-throughput

0.407

High

596841

EPB42
Protein 4.2

2

0

High-throughput

0.328

High

482273

PAEP
Glycodelin

1

0

High-throughput

0.279

Low

140030

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

420736

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

Small-scale

0.249

Low

941990

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

1381547

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.249

Low

1387027

HAVR1
Hepatitis A virus cellular receptor 1

1

0

Small-scale

0.249

Low

907120

CCR9
C-C chemokine receptor type 9

1

0

High-throughput

0.232

Low

1333519

GOLM1
Golgi membrane protein 1

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025