HitPredict

Interactor 1: KCTD2 (Q14681)
BTB/POZ domain-containing protein KCTD2 (Potassium channel tetramerization domain-containing protein 2)
Gene: KCTD2

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 263 Hs			1 337
+	Hs
		153919 KCTD2_HUMAN (1-263): 5.89e-84: 253: 100.00		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		1075465 KCTD5_HUMAN (66-263): 2.12e-73: 225: 80.81		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		153954 KCTD5_HUMAN (66-263): 2.12e-73: 225: 80.81		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		1075429 KCD17_HUMAN (72-254): 1.23e-58: 190: 72.13		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		1075459 BACD3_HUMAN (37-253): 1.35e-55: 182: 24.77		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		67909 KCTD2_HUMAN (1-263): 5.89e-84: 253: 100.00		PDZ1P_HUMAN (4-131): 1.03e-19: 91.2: 33.59
+	Hs
		1057225 KCTD2_HUMAN (1-263): 5.89e-84: 253: 100.00		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		67923 KCTD5_HUMAN (66-263): 2.12e-73: 225: 80.81		PDZ1P_HUMAN (4-131): 1.03e-19: 91.2: 33.59
+	Hs
		1057230 KCTD2_HUMAN (1-263): 5.89e-84: 253: 100.00		DLG3_HUMAN (89-220): 8.62e-10: 61.9: 17.99
+	Hs
		1057234 KCTD2_HUMAN (1-263): 5.89e-84: 253: 100.00		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		1132926 KCTD5_HUMAN (66-263): 2.12e-73: 225: 80.81		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		1296929 KCTD5_HUMAN (66-263): 2.12e-73: 225: 80.81		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		67915 KCD17_HUMAN (72-254): 1.23e-58: 190: 72.13		PDZ1P_HUMAN (4-131): 1.03e-19: 91.2: 33.59
+	Hs
		819567 KCNC1_HUMAN (65-258): 2.94e-62: 205: 17.73		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Rn
		626888 KCNC1_RAT (65-258): 2.39e-61: 204: 17.73		DLG1_RAT (87-232): 1.5e-13: 73.5: 18.30
+	Hs
		942389 KCND2_HUMAN (34-209): 4.57e-52: 180: 24.58		DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		1132909 KCD17_HUMAN (72-254): 1.23e-58: 190: 72.13		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		1050021 KCNB2_HUMAN (37-219): 3.46e-47: 169: 22.22		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Rn
		580271 KCNA5_RAT (8-216): 1.54e-46: 165: 19.09		DLG1_RAT (87-232): 1.5e-13: 73.5: 18.30
+	Hs
		67916 SHKB1_HUMAN (57-183): 2.75e-35: 135: 40.95		PDZ1P_HUMAN (4-131): 1.03e-19: 91.2: 33.59