Protein: PRDX6
Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12)

Gene: PRDX6
Organism: Homo sapiens
Interactions: 194
UniProt ID: P30041

Gene Ontology (top 5):
GO:0004601 - peroxidase activity
GO:0004602 - glutathione peroxidase activity
GO:0004623 - phospholipase A2 activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

716246

PRDX6
Peroxiredoxin-6

3

15

Small-scale

0.829

High

563263

CFTR
Cystic fibrosis transmembrane conductance regulator

3

4

High-throughput

0.662

High

529161

TAU
Microtubule-associated protein tau

3

10

High-throughput

0.650

High

240840

PRKN
E3 ubiquitin-protein ligase parkin

3

11

Small-scale

0.640

High

667561

CDK2
Cyclin-dependent kinase 2

3

9

Small-scale

0.640

High

353010

AGR2
Anterior gradient protein 2 homolog

2

5

Small-scale

0.601

High

550866

PCNA
Proliferating cell nuclear antigen

2

3

Small-scale

0.601

High

345415

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

371258

MYC
Myc proto-oncogene protein

2

9

High-throughput

0.584

High

536571

HSP7C
Heat shock cognate 71 kDa protein

2

3

Small-scale

0.584

High

716256

YAP1
Transcriptional coactivator YAP1

2

11

High-throughput

0.584

High

716332

CASPA
Caspase-10

1

1

Small-scale

0.582

High

716258

PSMD8
26S proteasome non-ATPase regulatory subunit 8

2

0

High-throughput

0.580

High

716261

TERF1
Telomeric repeat-binding factor 1

1

4

High-throughput

0.573

High

716293

CASP8
Caspase-8

1

1

Small-scale

0.573

High

584709

NDKA
Nucleoside diphosphate kinase A

2

4

High-throughput

0.571

High

619529

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

716272

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.561

High

697011

APEX1
DNA repair nuclease/redox regulator APEX1

2

0

Small-scale

0.559

High

484393

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

8

High-throughput

0.554

High

640774

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.554

High

626449

NCF2
Neutrophil cytosol factor 2

1

3

Small-scale

0.552

High

716317

STH
Saitohin

1

0

Small-scale

0.549

High

135512

DNM1L
Dynamin-1-like protein

1

3

High-throughput

0.536

High

213826

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

3

High-throughput

0.536

High

361130

SODC
Superoxide dismutase [Cu-Zn]

1

5

High-throughput

0.536

High

389070

FINC
Fibronectin

1

4

High-throughput

0.536

High

591495

H2AX
Histone H2AX

1

4

High-throughput

0.536

High

716250

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.536

High

716278

KPCZ
Protein kinase C zeta type

1

4

High-throughput

0.536

High

716287

CUL1
Cullin-1

1

18

High-throughput

0.536

High

716297

MYLK
Myosin light chain kinase, smooth muscle

1

2

High-throughput

0.536

High

716314

MYLK4
Myosin light chain kinase family member 4

1

1

High-throughput

0.536

High

716315

CDKL3
Cyclin-dependent kinase-like 3

1

12

High-throughput

0.536

High

716325

RIN3
Ras and Rab interactor 3

1

3

High-throughput

0.536

High

716327

NEK7
Serine/threonine-protein kinase Nek7

1

8

High-throughput

0.536

High

716333

SGK3
Serine/threonine-protein kinase Sgk3

1

5

High-throughput

0.536

High

716340

PARK7
Parkinson disease protein 7

1

4

High-throughput

0.536

High

716342

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

7

High-throughput

0.536

High

716347

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.536

High

716357

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.529

High

385483

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.513

High

716326

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

716361

RCAN3
Calcipressin-3

1

0

High-throughput

0.513

High

716310

COX15
Heme A synthase COX15

1

3

High-throughput

0.506

High

479771

GSTP1
Glutathione S-transferase P

1

3

Small-scale

0.501

High

703448

MK01
Mitogen-activated protein kinase 1

1

5

Small-scale

0.501

High

716269

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.501

High

716316

SFTA1
Pulmonary surfactant-associated protein A1

1

2

Small-scale

0.501

High

716341

SPS2
Selenide, water dikinase 2

1

1

Small-scale

0.501

High

716367

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

11

Small-scale

0.501

High

716355

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

0

High-throughput

0.493

High

716324

PPTC7
Protein phosphatase PTC7 homolog

1

1

High-throughput

0.489

High

520520

RARA
Retinoic acid receptor alpha

1

12

High-throughput

0.481

High

652452

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

13

High-throughput

0.481

High

716251

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

2

High-throughput

0.481

High

716277

PPARD
Peroxisome proliferator-activated receptor delta

1

7

High-throughput

0.481

High

716292

HNF4G
Hepatocyte nuclear factor 4-gamma

1

11

High-throughput

0.481

High

716308

PAXI1
PAX-interacting protein 1

1

6

High-throughput

0.481

High

125256

LEG9
Galectin-9

1

6

High-throughput

0.479

High

156988

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

257352

PAGE4
P antigen family member 4

1

1

High-throughput

0.479

High

259497

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

293256

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

315168

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

319435

UFL1
E3 UFM1-protein ligase 1

1

4

High-throughput

0.479

High

349819

SNAI1
Zinc finger protein SNAI1

1

4

High-throughput

0.479

High

377418

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

3

High-throughput

0.479

High

395555

ESR1
Estrogen receptor

1

16

High-throughput

0.479

High

400342

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

405821

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.479

High

408688

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

5

High-throughput

0.479

High

413259

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

420384

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.479

High

425337

ISG15
Ubiquitin-like protein ISG15

1

11

Small-scale

0.479

High

446685

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

482332

F16P1
Fructose-1,6-bisphosphatase 1

1

2

High-throughput

0.479

High

486993

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

507568

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.479

High

555895

CADH1
Cadherin-1

1

1

High-throughput

0.479

High

565171

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

583199

FOLR1
Folate receptor alpha

1

2

High-throughput

0.479

High

587989

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

599159

IL7RA
Interleukin-7 receptor subunit alpha

1

2

High-throughput

0.479

High

606286

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

615485

NELFE
Negative elongation factor E

1

1

High-throughput

0.479

High

623126

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

High-throughput

0.479

High

630697

RAB4A
Ras-related protein Rab-4A

1

5

High-throughput

0.479

High

694699

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

716247

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

716248

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

716252

MDHM
Malate dehydrogenase, mitochondrial

1

7

High-throughput

0.479

High

716253

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

716254

BCL6
B-cell lymphoma 6 protein

1

4

High-throughput

0.479

High

716257

SOX2
Transcription factor SOX-2

1

7

High-throughput

0.479

High

716260

CDK7
Cyclin-dependent kinase 7

1

9

High-throughput

0.479

High

716263

CTBP2
C-terminal-binding protein 2

1

6

High-throughput

0.479

High

716266

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

6

High-throughput

0.479

High

716268

UBC12
NEDD8-conjugating enzyme Ubc12

1

5

High-throughput

0.479

High

716270

WDR5
WD repeat-containing protein 5

1

7

High-throughput

0.479

High

716271

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

716273

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.479

High

716274

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

716275

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

716276

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

13

High-throughput

0.479

High

716279

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.479

High

716280

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.479

High

716282

DUS4
Dual specificity protein phosphatase 4

1

3

High-throughput

0.479

High

716283

RFA4
Replication protein A 30 kDa subunit

1

5

High-throughput

0.479

High

716284

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.479

High

716286

BIRC3
Baculoviral IAP repeat-containing protein 3

1

10

High-throughput

0.479

High

716288

CUL3
Cullin-3

1

18

High-throughput

0.479

High

716289

CUL4A
Cullin-4A

1

18

High-throughput

0.479

High

716290

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

1

High-throughput

0.479

High

716291

TRI14
Tripartite motif-containing protein 14

1

8

High-throughput

0.479

High

716294

CUL7
Cullin-7

1

4

High-throughput

0.479

High

716295

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

716296

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

716299

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

716300

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

716301

EMC4
ER membrane protein complex subunit 4

1

1

High-throughput

0.479

High

716302

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.479

High

716303

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

716304

PRP8
Pre-mRNA-processing-splicing factor 8

1

4

High-throughput

0.479

High

716305

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

716307

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

716311

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.479

High

716312

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

716313

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

716320

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.479

High

716321

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

716322

RN149
E3 ubiquitin-protein ligase RNF149

1

6

High-throughput

0.479

High

716323

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

716328

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

716329

ASB12
Ankyrin repeat and SOCS box protein 12

1

6

High-throughput

0.479

High

716330

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

11

High-throughput

0.479

High

716331

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

716334

CHM4C
Charged multivesicular body protein 4c

1

6

High-throughput

0.479

High

716336

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

716337

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

716339

CIC
Protein capicua homolog

1

8

High-throughput

0.479

High

716343

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.479

High

716344

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.479

High

716345

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

716346

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

4

High-throughput

0.479

High

716348

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

716350

WWTR1
WW domain-containing transcription regulator protein 1

1

8

High-throughput

0.479

High

716354

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

716356

PIHD1
PIH1 domain-containing protein 1

1

4

High-throughput

0.479

High

716358

HDAC6
Protein deacetylase HDAC6

1

8

High-throughput

0.479

High

716359

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

716360

DS13B
Dual specificity protein phosphatase 13B

1

3

High-throughput

0.479

High

716362

HDAC5
Histone deacetylase 5

1

8

High-throughput

0.479

High

716363

RUVB1
RuvB-like 1

1

2

High-throughput

0.479

High

716365

TRAF6
TNF receptor-associated factor 6

1

11

Small-scale

0.479

High

716366

ASB3
Ankyrin repeat and SOCS box protein 3

1

5

High-throughput

0.479

High

624702

A1AG2
Alpha-1-acid glycoprotein 2

1

0

High-throughput

0.460

High

123335

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

246274

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

0

High-throughput

0.458

High

336870

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

488725

FURIN
Furin

1

0

High-throughput

0.458

High

642646

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

716298

MSMO1
Methylsterol monooxygenase 1

1

0

High-throughput

0.458

High

184590

MK13
Mitogen-activated protein kinase 13

1

10

Small-scale

0.445

High

244930

KATIP
Katanin-interacting protein

1

1

High-throughput

0.445

High

429365

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

716255

RAD52
DNA repair protein RAD52 homolog

1

2

Small-scale

0.445

High

716262

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.445

High

716264

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.445

High

716265

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.445

High

716267

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

716285

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.445

High

716319

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

716335

OTUB1
Ubiquitin thioesterase OTUB1

1

2

High-throughput

0.445

High

716338

CEP63
Centrosomal protein of 63 kDa

1

6

High-throughput

0.445

High

716351

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

716352

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

High-throughput

0.445

High

444907

S10A9
Protein S100-A9

1

0

Small-scale

0.438

High

94498

CD054
Uncharacterized protein C4orf54

1

2

High-throughput

0.437

High

105410

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

239744

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

411427

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

716249

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

716259

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

716281

ZBT17
Zinc finger and BTB domain-containing protein 17

1

3

Small-scale

0.437

High

716309

ASXL2
Putative Polycomb group protein ASXL2

1

10

High-throughput

0.437

High

716318

ASXL1
Polycomb group protein ASXL1

1

9

High-throughput

0.437

High

716349

ASXL3
Putative Polycomb group protein ASXL3

1

11

High-throughput

0.437

High

716353

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.437

High

716364

AAR2
Protein AAR2 homolog

1

4

High-throughput

0.437

High

425174

IPSP
Plasma serine protease inhibitor

1

0

Small-scale

0.426

High

87342

OSCRI
SCRIB overlapping open reading frame protein

1

1

High-throughput

0.407

High

716306

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

2

High-throughput

0.407

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025