HitPredict

Interactor 1: KCTD2 (Q14681)
BTB/POZ domain-containing protein KCTD2 (Potassium channel tetramerization domain-containing protein 2)
Gene: KCTD2

Interactor 2: NHRF3 (Q5T2W1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
Gene: PDZK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 263 Hs			1 519
+	Hs
		1132926 KCTD5_HUMAN (66-263): 2.12e-73: 225: 80.81		NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00
+	Hs
		1132909 KCD17_HUMAN (72-254): 1.23e-58: 190: 72.13		NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00
+	Hs
		1057230 KCTD2_HUMAN (1-263): 5.89e-84: 253: 100.00		DLG3_HUMAN (3-359): 3.36e-32: 133: 17.27
+	Hs
		153919 KCTD2_HUMAN (1-263): 5.89e-84: 253: 100.00		NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54
+	Hs
		1057222 KCTD2_HUMAN (1-263): 5.89e-84: 253: 100.00		NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17
+	Hs
		67909 KCTD2_HUMAN (1-263): 5.89e-84: 253: 100.00		PDZ1P_HUMAN (6-134): 6.25e-18: 87.9: 28.68
+	Hs
		153954 KCTD5_HUMAN (66-263): 2.12e-73: 225: 80.81		NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54
+	Hs
		942389 KCND2_HUMAN (34-209): 4.57e-52: 180: 24.58		DLG4_HUMAN (3-344): 2.27e-36: 145: 17.22
+	Hs
		1075465 KCTD5_HUMAN (66-263): 2.12e-73: 225: 80.81		NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17
+	Hs
		67923 KCTD5_HUMAN (66-263): 2.12e-73: 225: 80.81		PDZ1P_HUMAN (6-134): 6.25e-18: 87.9: 28.68
+	Hs
		819567 KCNC1_HUMAN (65-258): 2.94e-62: 205: 17.73		DLG1_HUMAN (289-461): 1.6e-16: 85.1: 18.52
+	Rn
		626888 KCNC1_RAT (65-258): 2.39e-61: 204: 17.73		DLG1_RAT (4-182): 1.08e-16: 85.5: 19.58
+	Hs
		1235348 KCD17_HUMAN (72-254): 1.23e-58: 190: 72.13		LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74
+	Hs
		1075429 KCD17_HUMAN (72-254): 1.23e-58: 190: 72.13		NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17
+	Hs
		67915 KCD17_HUMAN (72-254): 1.23e-58: 190: 72.13		PDZ1P_HUMAN (6-134): 6.25e-18: 87.9: 28.68
+	Hs
		1075459 BACD3_HUMAN (37-253): 1.35e-55: 182: 24.77		NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17
+	Hs
		1045929 BACD2_HUMAN (59-253): 3.28e-53: 176: 26.53		LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74
+	Hs
		1252368 BACD1_HUMAN (52-252): 4.42e-53: 176: 23.27		LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74
+	Hs
		1050021 KCNB2_HUMAN (37-219): 3.46e-47: 169: 22.22		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Rn
		580271 KCNA5_RAT (8-216): 1.54e-46: 165: 19.09		DLG1_RAT (4-182): 1.08e-16: 85.5: 19.58