Interactor 1: SMC1A (Q14683)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Gene: SMC1A

Interactor 2: SMC3 (Q9UQE7)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)
Gene: SMC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 26496610, 27173435, 12759374, 31010829, 9789013, 24981860, 17113138, 17349791, 10931856, 21880767, 11877376, 30021884, 11590136, 31807710, 35271311, 23242214, 34349018, 35235311, 37071682, 22885700 and 3 others

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Identification Methods affinity chromatography technology, proximity labelling technology, biochemical, cross-linking study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains SMC_hinge~SMC_hinge, SMC_N~SMC_N
Common GO terms GO:0000775 - chromosome, centromeric region
GO:0003682 - chromatin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 18 others

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Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1233
Hs

1 1217
+ Mm
+ Bt
+ Xl
+ Xl
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Sc
+ Hs
+ Ce
+ Sc
+ Ce
+ Sp
+ Xl
+ Sc
+ Sc

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Last updated: 15 Jul 2024