Protein: ATP7B
Copper-transporting ATPase 2 (EC 7.2.2.8) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa]

Gene: ATP7B
Organism: Homo sapiens
Interactions: 54
UniProt ID: P35670

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005375 - copper ion transmembrane transporter activity
GO:0005507 - copper ion binding
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

128565

ATOX1
Copper transport protein ATOX1

5

6

Small-scale

0.930

High

775770

COMD1
COMM domain-containing protein 1

3

1

Small-scale

0.678

High

775757

NRG1
Pro-neuregulin-1, membrane-bound isoform

3

1

High-throughput

0.667

High

49440

TM223
Transmembrane protein 223

2

1

High-throughput

0.628

High

225443

ITM2A
Integral membrane protein 2A

2

10

High-throughput

0.628

High

720596

GRPR
Gastrin-releasing peptide receptor

2

19

High-throughput

0.628

High

775780

CLC2D
C-type lectin domain family 2 member D

2

10

High-throughput

0.628

High

775786

PCDGD
Protocadherin gamma-B1

2

10

High-throughput

0.628

High

775778

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

533607

CLUS
Clusterin

2

2

Small-scale

0.584

High

640368

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

20

High-throughput

0.536

High

775756

X3CL1
Fractalkine

1

2

High-throughput

0.536

High

775760

NTRK3
NT-3 growth factor receptor

1

10

High-throughput

0.536

High

775776

TTYH1
Protein tweety homolog 1

1

2

High-throughput

0.536

High

775779

KCMB3
Calcium-activated potassium channel subunit beta-3

1

2

High-throughput

0.536

High

775783

TSN16
Tetraspanin-16

1

13

High-throughput

0.536

High

775787

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

553420

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

0

High-throughput

0.513

High

775751

GLRX1
Glutaredoxin-1

1

2

Small-scale

0.504

High

178200

NPC1
NPC intracellular cholesterol transporter 1

1

6

High-throughput

0.479

High

217900

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

240919

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

293299

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

561924

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.479

High

775752

RAB7A
Ras-related protein Rab-7a

1

11

High-throughput

0.479

High

775753

RAB9A
Ras-related protein Rab-9A

1

11

High-throughput

0.479

High

775759

VAMP3
Vesicle-associated membrane protein 3

1

6

High-throughput

0.479

High

775763

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

775766

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.479

High

775768

CXD3
Gap junction delta-3 protein

1

8

High-throughput

0.479

High

775771

RN149
E3 ubiquitin-protein ligase RNF149

1

7

High-throughput

0.479

High

775774

GOGA1
Golgin subfamily A member 1

1

2

High-throughput

0.479

High

775777

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

775785

LAMP3
Lysosome-associated membrane glycoprotein 3

1

7

High-throughput

0.479

High

775762

HAUS3
HAUS augmin-like complex subunit 3

1

0

High-throughput

0.458

High

133055

EAA5
Excitatory amino acid transporter 5

1

2

High-throughput

0.445

High

775754

GPC3
Glypican-3

1

1

High-throughput

0.445

High

775764

NIPA3
Magnesium transporter NIPA3

1

3

High-throughput

0.445

High

775765

NPAL3
NIPA-like protein 3

1

3

High-throughput

0.445

High

775772

ZNT7
Zinc transporter 7

1

3

High-throughput

0.445

High

775773

S35F5
Solute carrier family 35 member F5

1

3

High-throughput

0.445

High

775775

DIRC2
Solute carrier family 49 member 4

1

1

High-throughput

0.445

High

775784

YLAT1
Y+L amino acid transporter 1

1

3

High-throughput

0.445

High

366158

HPT
Haptoglobin

1

1

Small-scale

0.439

High

174491

TRI66
Tripartite motif-containing protein 66

1

3

High-throughput

0.437

High

630705

RAB4A
Ras-related protein Rab-4A

1

7

High-throughput

0.437

High

679309

DNJB2
DnaJ homolog subfamily B member 2

1

2

High-throughput

0.437

High

775755

IMA5
Importin subunit alpha-5

1

1

High-throughput

0.437

High

775769

KT222
Keratin-like protein KRT222

1

1

High-throughput

0.437

High

775781

XPO7
Exportin-7

1

3

High-throughput

0.437

High

775767

MFS6L
Major facilitator superfamily domain-containing protein 6-like

1

0

High-throughput

0.426

High

775761

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

775758

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

Small-scale

0.299

High

775782

DCTN4
Dynactin subunit 4

1

0

Small-scale

0.288

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025