Protein: ATP7A
Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein)

Gene: ATP7A
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q04656

Gene Ontology (top 5):
GO:0001568 - blood vessel development
GO:0001836 - release of cytochrome c from mitochondria
GO:0001974 - blood vessel remodeling
GO:0002082 - regulation of oxidative phosphorylation
GO:0005375 - copper ion transmembrane transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

128571

ATOX1
Copper transport protein ATOX1

2

6

Small-scale

0.786

High

1047237

APBB2
Amyloid beta precursor protein binding family B member 2

4

3

High-throughput

0.691

High

1047251

CLC2D
C-type lectin domain family 2 member D

3

8

High-throughput

0.662

High

170498

RAB7L
Ras-related protein Rab-7L1

2

8

High-throughput

0.628

High

225446

ITM2A
Integral membrane protein 2A

2

8

High-throughput

0.628

High

1029595

CD83
CD83 antigen

2

1

High-throughput

0.628

High

1047219

C3AR
C3a anaphylatoxin chemotactic receptor

2

17

High-throughput

0.628

High

1047224

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

2

8

High-throughput

0.628

High

679330

DNJB2
DnaJ homolog subfamily B member 2

2

2

High-throughput

0.611

High

840687

RS27
Small ribosomal subunit protein eS27

2

1

High-throughput

0.611

High

1047258

LAMP3
Lysosome-associated membrane glycoprotein 3

2

8

High-throughput

0.611

High

1047257

COG5
Conserved oligomeric Golgi complex subunit 5

2

0

High-throughput

0.602

High

1047260

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.602

High

1047218

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

1

High-throughput

0.601

High

375435

RASK
GTPase KRas

2

11

High-throughput

0.584

High

977952

RHOB
Rho-related GTP-binding protein RhoB

2

17

High-throughput

0.584

High

1047222

PDZ11
PDZ domain-containing protein 11

1

0

Small-scale

0.564

High

776885

GLRX1
Glutaredoxin-1

1

2

Small-scale

0.552

High

488776

FURIN
Furin

1

1

High-throughput

0.536

High

711552

NK3R
Neuromedin-K receptor

1

8

High-throughput

0.536

High

919902

PLK1
Serine/threonine-protein kinase PLK1

1

5

High-throughput

0.536

High

920694

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

1

High-throughput

0.536

High

1007862

X3CL1
Fractalkine

1

2

High-throughput

0.536

High

1047212

FOXF2
Forkhead box protein F2

1

2

High-throughput

0.536

High

1047213

KLRD1
Natural killer cells antigen CD94

1

8

High-throughput

0.536

High

1047239

ORAI1
Calcium release-activated calcium channel protein 1

1

1

High-throughput

0.536

High

1047242

IFT27
Intraflagellar transport protein 27 homolog

1

6

High-throughput

0.536

High

1047244

SEM4C
Semaphorin-4C

1

1

High-throughput

0.536

High

1047246

CHODL
Chondrolectin

1

2

High-throughput

0.536

High

1047250

HCST
Hematopoietic cell signal transducer

1

1

High-throughput

0.536

High

1047254

TSN16
Tetraspanin-16

1

10

High-throughput

0.536

High

1047262

PCDGD
Protocadherin gamma-B1

1

9

High-throughput

0.536

High

1047214

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

2

High-throughput

0.515

High

407168

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

High-throughput

0.513

High

1047226

CK087
Uncharacterized protein C11orf87

1

0

High-throughput

0.513

High

1047230

TM130
Transmembrane protein 130

1

0

High-throughput

0.513

High

1047243

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

1047261

O10H1
Olfactory receptor 10H1

1

0

High-throughput

0.513

High

1047215

LAGE3
EKC/KEOPS complex subunit LAGE3

1

2

High-throughput

0.489

High

1047235

HUMMR
Protein MGARP

1

1

High-throughput

0.489

High

1047253

KLK12
Kallikrein-12

1

3

High-throughput

0.489

High

479600

DOPO
Dopamine beta-hydroxylase

1

0

Small-scale

0.479

High

125418

LEG9
Galectin-9

1

2

High-throughput

0.479

High

189525

STX7
Syntaxin-7

1

4

High-throughput

0.479

High

218086

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.479

High

341034

DIRA3
GTP-binding protein Di-Ras3

1

3

High-throughput

0.479

High

373893

RASN
GTPase NRas

1

11

High-throughput

0.479

High

374541

RASH
GTPase HRas

1

7

High-throughput

0.479

High

411777

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.479

High

463471

LYN
Tyrosine-protein kinase Lyn

1

3

High-throughput

0.479

High

466216

RHOC
Rho-related GTP-binding protein RhoC

1

15

High-throughput

0.479

High

533645

CLUS
Clusterin

1

2

Small-scale

0.479

High

540413

LAMP1
Lysosome-associated membrane glycoprotein 1

1

8

High-throughput

0.479

High

562011

LAMP2
Lysosome-associated membrane glycoprotein 2

1

8

High-throughput

0.479

High

580618

AMPN
Aminopeptidase N

1

2

High-throughput

0.479

High

603942

CXA1
Gap junction alpha-1 protein

1

8

High-throughput

0.479

High

630774

RAB4A
Ras-related protein Rab-4A

1

6

High-throughput

0.479

High

642817

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

5

High-throughput

0.479

High

692937

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

710190

EPHA2
Ephrin type-A receptor 2

1

4

High-throughput

0.479

High

778053

VGFR2
Vascular endothelial growth factor receptor 2

1

1

Small-scale

0.479

High

845611

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.479

High

900782

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.479

High

901199

RAB7A
Ras-related protein Rab-7a

1

9

High-throughput

0.479

High

953405

RAC3
Ras-related C3 botulinum toxin substrate 3

1

15

High-throughput

0.479

High

956262

RAB2A
Ras-related protein Rab-2A

1

6

High-throughput

0.479

High

961977

RHOA
Transforming protein RhoA

1

16

High-throughput

0.479

High

988303

RAC1
Ras-related C3 botulinum toxin substrate 1

1

15

High-throughput

0.479

High

1047217

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.479

High

1047220

OCLN
Occludin

1

1

High-throughput

0.479

High

1047225

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.479

High

1047227

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.479

High

1047229

CXD3
Gap junction delta-3 protein

1

8

High-throughput

0.479

High

1047231

COMD1
COMM domain-containing protein 1

1

1

Small-scale

0.479

High

1047232

RN149
E3 ubiquitin-protein ligase RNF149

1

5

High-throughput

0.479

High

1047241

SNX27
Sorting nexin-27

1

6

Small-scale

0.479

High

1047245

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

1047247

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1047256

ALK
ALK tyrosine kinase receptor

1

10

High-throughput

0.479

High

1047263

ARL5A
ADP-ribosylation factor-like protein 5A

1

5

High-throughput

0.479

High

1047216

T132D
Transmembrane protein 132D

1

0

Small-scale

0.460

High

139206

UPK2
Uroplakin-2

1

2

High-throughput

0.445

High

212391

SPIT2
Kunitz-type protease inhibitor 2

1

4

High-throughput

0.445

High

641941

CD9
CD9 antigen

1

8

High-throughput

0.445

High

914410

EFNB2
Ephrin-B2

1

2

High-throughput

0.445

High

1010021

DLK1
Protein delta homolog 1

1

2

High-throughput

0.445

High

1047211

TNR9
Tumor necrosis factor receptor superfamily member 9

1

9

High-throughput

0.445

High

1047233

ZNT7
Zinc transporter 7

1

4

High-throughput

0.445

High

1047234

DNJB8
DnaJ homolog subfamily B member 8

1

3

High-throughput

0.445

High

1047259

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

4

High-throughput

0.445

High

1047228

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1047238

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1047249

ARL15
ADP-ribosylation factor-like protein 15

1

6

High-throughput

0.437

High

1047252

XPO7
Exportin-7

1

3

High-throughput

0.437

High

222267

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

379505

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.426

High

469476

SYPH
Synaptophysin

1

0

High-throughput

0.426

High

1047236

SSMM1
Serine-rich single-pass membrane protein 1

1

0

High-throughput

0.426

High

1047240

DTBP1
Dysbindin

1

0

Small-scale

0.426

High

1047255

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

0

Small-scale

0.426

High

912174

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.279

Low

1047223

LY65C
Lymphocyte antigen 6 complex locus protein G5c

1

0

High-throughput

0.279

Low

1047248

OLFL3
Olfactomedin-like protein 3

1

0

High-throughput

0.249

Low

1047221

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025