HitPredict

Interactor 1: NCOA6 (Q14686)
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
Gene: NCOA6

Interactor 2: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27703004
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 2063 Hs			1 465
+	Hs
		950184 NCOA6_HUMAN (1-2063): 0: 746: 100.00		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Hs
		1057763 NCOA6_HUMAN (1-2063): 0: 746: 100.00		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Hs
		171421 ARI1B_HUMAN (582-2022): 5.83e-14: 80.2: 10.54		SMAD9_HUMAN (3-465): 0: 607: 81.29
+	Hs
		1078592 ARI1B_HUMAN (582-2022): 5.83e-14: 80.2: 10.54		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Hs
		1078590 KMT2C_HUMAN (535-1739): 1.33e-10: 69.2: 11.23		SMAD2_HUMAN (3-465): 0: 541: 55.14