Protein: DSG1
Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen)

Gene: DSG1
Organism: Homo sapiens
Interactions: 192
UniProt ID: Q02413

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005509 - calcium ion binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

542285

PLAK
Junction plakoglobin

3

20

Small-scale

0.840

High

970760

DSC1
Desmocollin-1

3

17

Small-scale

0.840

High

970770

PKP1
Plakophilin-1

3

20

Small-scale

0.840

High

970835

PKP2
Plakophilin-2

1

20

Small-scale

0.713

High

970865

PKP3
Plakophilin-3

1

20

Small-scale

0.713

High

374081

RAF1
RAF proto-oncogene serine/threonine-protein kinase

4

7

High-throughput

0.672

High

346564

MYC
Myc proto-oncogene protein

3

9

High-throughput

0.640

High

970755

DSC2
Desmocollin-2

1

17

Small-scale

0.618

High

970855

PD1L1
Programmed cell death 1 ligand 1

1

9

High-throughput

0.618

High

369439

ESR1
Estrogen receptor

2

9

High-throughput

0.611

High

883409

CF298
Cilia- and flagella-associated protein 298

2

0

High-throughput

0.602

High

551674

DESP
Desmoplakin

2

11

Small-scale

0.595

High

386560

P53
Cellular tumor antigen p53

2

3

Small-scale

0.584

High

779267

CCNF
Cyclin-F

2

6

High-throughput

0.584

High

970783

LARP7
La-related protein 7

2

2

High-throughput

0.584

High

970861

FBW1A
F-box/WD repeat-containing protein 1A

2

2

High-throughput

0.584

High

970851

TB22B
TBC1 domain family member 22B

2

6

High-throughput

0.574

High

433706

LYN
Tyrosine-protein kinase Lyn

2

11

High-throughput

0.571

High

488686

ARAF
Serine/threonine-protein kinase A-Raf

2

7

High-throughput

0.571

High

528996

CFTR
Cystic fibrosis transmembrane conductance regulator

2

6

Small-scale

0.571

High

557662

NCK1
SH2/SH3 adapter protein NCK1

2

12

High-throughput

0.571

High

671643

PEBP1
Phosphatidylethanolamine-binding protein 1

2

1

High-throughput

0.571

High

681797

AKT1
RAC-alpha serine/threonine-protein kinase

2

4

High-throughput

0.571

High

734916

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

2

9

High-throughput

0.571

High

846459

BLK
Tyrosine-protein kinase Blk

2

10

High-throughput

0.571

High

970767

GAB1
GRB2-associated-binding protein 1

2

9

High-throughput

0.571

High

970780

RBP1
RalA-binding protein 1

2

11

High-throughput

0.571

High

970819

ARH40
Rho guanine nucleotide exchange factor 40

2

5

High-throughput

0.571

High

970858

GAB2
GRB2-associated-binding protein 2

2

9

High-throughput

0.571

High

970859

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

1

High-throughput

0.571

High

548899

NDKA
Nucleoside diphosphate kinase A

2

0

High-throughput

0.547

High

403196

LA
Lupus La protein

1

2

High-throughput

0.536

High

515402

CDK4
Cyclin-dependent kinase 4

1

5

High-throughput

0.536

High

548686

VAV
Proto-oncogene vav

1

5

High-throughput

0.536

High

565911

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.536

High

809272

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

6

High-throughput

0.536

High

861705

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.536

High

882720

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

970758

RAD51
DNA repair protein RAD51 homolog 1

1

1

High-throughput

0.536

High

970764

MK07
Mitogen-activated protein kinase 7

1

6

High-throughput

0.536

High

970769

CUL2
Cullin-2

1

5

High-throughput

0.536

High

970779

PMVK
Phosphomevalonate kinase

1

1

High-throughput

0.536

High

970799

SAMD1
Sterile alpha motif domain-containing protein 1

1

2

High-throughput

0.536

High

970804

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

3

High-throughput

0.536

High

970808

ZC3C1
Zinc finger C3HC-type protein 1

1

2

High-throughput

0.536

High

970845

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

3

High-throughput

0.536

High

970801

SYDE1
Rho GTPase-activating protein SYDE1

2

8

High-throughput

0.521

High

296294

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

4

High-throughput

0.515

High

970782

H2B2E
Histone H2B type 2-E

1

3

High-throughput

0.515

High

970824

H2B1H
Histone H2B type 1-H

1

3

High-throughput

0.515

High

921107

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.513

High

970777

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

970823

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

893915

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.501

High

966521

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.493

High

725774

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.489

High

970821

ZDH19
Palmitoyltransferase ZDHHC19

1

6

High-throughput

0.489

High

133985

DDX3X
ATP-dependent RNA helicase DDX3X

1

2

Small-scale

0.479

High

170341

TIF1A
Transcription intermediary factor 1-alpha

1

4

Small-scale

0.479

High

227213

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

282630

RNF8
E3 ubiquitin-protein ligase RNF8

1

8

High-throughput

0.479

High

301771

TRI37
E3 ubiquitin-protein ligase TRIM37

1

6

High-throughput

0.479

High

325696

LATS1
Serine/threonine-protein kinase LATS1

1

6

High-throughput

0.479

High

379306

MYCN
N-myc proto-oncogene protein

1

8

High-throughput

0.479

High

384674

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

396224

ARGI1
Arginase-1

1

1

High-throughput

0.479

High

427526

ANXA2
Annexin A2

1

7

High-throughput

0.479

High

455338

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

456551

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

3

Small-scale

0.479

High

503928

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

552531

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

569614

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

596268

FILA
Filaggrin

1

5

High-throughput

0.479

High

614008

TBG1
Tubulin gamma-1 chain

1

5

High-throughput

0.479

High

625375

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

650997

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

683067

CASPE
Caspase-14

1

3

High-throughput

0.479

High

708608

MCM5
DNA replication licensing factor MCM5

1

4

High-throughput

0.479

High

795735

MAGA3
Melanoma-associated antigen 3

1

3

Small-scale

0.479

High

832383

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

851315

NEK2
Serine/threonine-protein kinase Nek2

1

5

Small-scale

0.479

High

867858

HIRA
Protein HIRA

1

3

Small-scale

0.479

High

890615

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.479

High

902881

DCAF7
DDB1- and CUL4-associated factor 7

1

6

High-throughput

0.479

High

908399

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

927801

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

2

High-throughput

0.479

High

940797

RNF4
E3 ubiquitin-protein ligase RNF4

1

6

High-throughput

0.479

High

961056

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

964908

FABP5
Fatty acid-binding protein 5

1

1

High-throughput

0.479

High

969624

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.479

High

970756

UBXN1
UBX domain-containing protein 1

1

3

High-throughput

0.479

High

970757

K1C17
Keratin, type I cytoskeletal 17

1

2

High-throughput

0.479

High

970759

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

2

High-throughput

0.479

High

970761

RBBP4
Histone-binding protein RBBP4

1

3

High-throughput

0.479

High

970762

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

2

High-throughput

0.479

High

970765

ERCC8
DNA excision repair protein ERCC-8

1

7

High-throughput

0.479

High

970768

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

970771

DX39B
Spliceosome RNA helicase DDX39B

1

7

High-throughput

0.479

High

970772

BLMH
Bleomycin hydrolase

1

2

High-throughput

0.479

High

970773

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

8

High-throughput

0.479

High

970774

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

2

High-throughput

0.479

High

970775

TNIP1
TNFAIP3-interacting protein 1

1

10

High-throughput

0.479

High

970776

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

970778

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.479

High

970781

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

970784

Q4LE69
1-phosphatidylinositol 4-kinase

1

7

High-throughput

0.479

High

970785

DCAF6
DDB1- and CUL4-associated factor 6

1

4

High-throughput

0.479

High

970787

FILA2
Filaggrin-2

1

6

High-throughput

0.479

High

970790

DCA12
DDB1- and CUL4-associated factor 12

1

1

High-throughput

0.479

High

970791

KPRP
Keratinocyte proline-rich protein

1

1

High-throughput

0.479

High

970794

SYDE2
Rho GTPase-activating protein SYDE2

1

11

High-throughput

0.479

High

970800

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

970803

DET1
DET1 homolog

1

1

High-throughput

0.479

High

970805

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

970806

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

970809

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.479

High

970810

HORN
Hornerin

1

5

High-throughput

0.479

High

970811

VRK3
Serine/threonine-protein kinase VRK3

1

6

High-throughput

0.479

High

970812

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

970814

DOCK8
Dedicator of cytokinesis protein 8

1

1

High-throughput

0.479

High

970815

NUP43
Nucleoporin Nup43

1

6

High-throughput

0.479

High

970816

COP1
E3 ubiquitin-protein ligase COP1

1

6

High-throughput

0.479

High

970817

CEP76
Centrosomal protein of 76 kDa

1

1

High-throughput

0.479

High

970818

POC1B
POC1 centriolar protein homolog B

1

2

High-throughput

0.479

High

970822

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

970825

KISSR
KiSS-1 receptor

1

3

Small-scale

0.479

High

970826

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

2

Small-scale

0.479

High

970827

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

2

High-throughput

0.479

High

970830

SPB12
Serpin B12

1

1

High-throughput

0.479

High

970831

PKH4B
Pleckstrin homology domain-containing family G member 4B

1

5

High-throughput

0.479

High

970832

RANB9
Ran-binding protein 9

1

6

Small-scale

0.479

High

970837

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

12

High-throughput

0.479

High

970838

FACD2
Fanconi anemia group D2 protein

1

3

High-throughput

0.479

High

970839

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

970842

PRD14
PR domain zinc finger protein 14

1

2

Small-scale

0.479

High

970844

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

970846

S10AE
Protein S100-A14

1

7

High-throughput

0.479

High

970847

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

970849

ANLN
Anillin

1

5

High-throughput

0.479

High

970850

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

970852

DCA13
DDB1- and CUL4-associated factor 13

1

4

High-throughput

0.479

High

970853

WSB2
WD repeat and SOCS box-containing protein 2

1

3

High-throughput

0.479

High

970857

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

970860

RUVB1
RuvB-like 1

1

1

High-throughput

0.479

High

970862

ST38L
Serine/threonine-protein kinase 38-like

1

6

High-throughput

0.479

High

970863

FND3A
Fibronectin type-III domain-containing protein 3A

1

14

High-throughput

0.479

High

970864

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

5

Small-scale

0.479

High

182708

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

322498

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

345074

CYTA
Cystatin-A

1

0

High-throughput

0.458

High

453299

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

868148

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

970763

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

970793

ARM12
Armadillo repeat-containing protein 12

1

0

Small-scale

0.458

High

970795

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

0

High-throughput

0.458

High

970796

CDC73
Parafibromin

1

0

High-throughput

0.458

High

970797

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

970798

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

970834

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

970856

MBD5
Methyl-CpG-binding domain protein 5

1

0

High-throughput

0.458

High

496882

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

602245

CD9
CD9 antigen

1

4

High-throughput

0.445

High

787642

PI4KA
Phosphatidylinositol 4-kinase alpha

1

7

High-throughput

0.445

High

887815

CD81
CD81 antigen

1

4

Small-scale

0.445

High

891095

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

High-throughput

0.445

High

958659

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

2

High-throughput

0.445

High

968564

TAGL
Transgelin

1

8

High-throughput

0.445

High

970786

ODFP2
Outer dense fiber protein 2

1

7

High-throughput

0.445

High

970789

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

970833

ZBT18
Zinc finger and BTB domain-containing protein 18

1

4

High-throughput

0.445

High

970840

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

4

High-throughput

0.445

High

970843

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

720266

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

970788

DCA10
DDB1- and CUL4-associated factor 10

1

4

High-throughput

0.437

High

970792

KPLCE
Protein KPLCE

1

1

High-throughput

0.437

High

970807

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.437

High

970820

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

970841

DDX24
ATP-dependent RNA helicase DDX24

1

5

High-throughput

0.437

High

200541

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

970766

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

1019

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

970813

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

6

High-throughput

0.407

High

970828

MITOK
Mitochondrial potassium channel

2

0

High-throughput

0.328

High

303680

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

970829

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

970848

TSSP
Thymus-specific serine protease

1

0

High-throughput

0.279

Low

224925

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.269

Low

970802

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

0

High-throughput

0.269

Low

351750

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

946499

DCD
Dermcidin

1

0

High-throughput

0.249

Low

970836

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low

970854

Q9NZ47
HCG1811444

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024