HitPredict

Interactor 1: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8

Interactor 2: TRADD (Q15628)
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)
Gene: TRADD

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

The method score is based on:

Property	Details
Experiments	30561431, 12887920, 29108854, 18776134, 17047155, 15173123, 22421964, 19524513
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, virotrap, anti bait coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005164 - tumor necrosis factor receptor binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0006915 - apoptotic process and 7 others more... GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0030335 - positive regulation of cell migration GO:0031264 - death-inducing signaling complex GO:0043065 - positive regulation of apoptotic process GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0044877 - protein-containing complex binding GO:0097191 - extrinsic apoptotic signaling pathway
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	479
Hs

1	312

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024