HitPredict

Interactor 1: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8

Interactor 2: BIRC6 (Q9NR09)
Baculoviral IAP repeat-containing protein 6 (EC 2.3.2.27) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (RING-type E3 ubiquitin transferase BIRC6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON)
Gene: BIRC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15507451
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BIR~Peptidase_C14
Common GO terms	GO:0005829 - cytosol GO:0006915 - apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 479 Hs			1 4857
+	Hs
		877004 CASP9_HUMAN (142-479): 5.98e-105: 320: 27.01		BIRC6_HUMAN (1-4857): 0: 7977: 100.00
+	Hs
		876964 CASP7_HUMAN (176-476): 1.44e-98: 300: 34.09		BIRC6_HUMAN (1-4857): 0: 7977: 100.00
+	Hs
		1035745 CASP8_HUMAN (1-479): 0: 600: 100.00		BIRC3_HUMAN (273-395): 1.46e-20: 101: 21.95
+	Hs
		957707 CASP8_HUMAN (1-479): 0: 600: 100.00		XIAP_HUMAN (282-437): 1.32e-20: 100: 14.48
+	Hs
		1036271 CASP8_HUMAN (1-479): 0: 600: 100.00		BIRC2_HUMAN (254-436): 3.68e-19: 97.5: 12.45
+	Hs
		181612 CFLAR_HUMAN (5-476): 9.95e-137: 404: 25.30		BIRC3_HUMAN (273-395): 1.46e-20: 101: 21.95
+	Hs
		1035946 CASPA_HUMAN (1-447): 1.34e-134: 400: 31.76		BIRC3_HUMAN (273-395): 1.46e-20: 101: 21.95
+	Hs
		957749 CASPA_HUMAN (1-447): 1.34e-134: 400: 31.76		XIAP_HUMAN (282-437): 1.32e-20: 100: 14.48
+	Hs
		1036308 CASPA_HUMAN (1-447): 1.34e-134: 400: 31.76		BIRC2_HUMAN (254-436): 3.68e-19: 97.5: 12.45
+	Hs
		830276 CASP4_HUMAN (94-479): 3.54e-106: 322: 19.06		XIAP_HUMAN (282-437): 1.32e-20: 100: 14.48
+	Hs
		876980 CASP9_HUMAN (142-479): 5.98e-105: 320: 27.01		BIRC3_HUMAN (273-395): 1.46e-20: 101: 21.95
+	Hs
		876972 CASP9_HUMAN (142-479): 5.98e-105: 320: 27.01		XIAP_HUMAN (282-437): 1.32e-20: 100: 14.48
+	Hs
		876981 CASP9_HUMAN (142-479): 5.98e-105: 320: 27.01		BIRC2_HUMAN (254-436): 3.68e-19: 97.5: 12.45
+	Rn
		1337442 Q9JHK1_RAT (169-479): 1.42e-100: 310: 28.53		XIAP_RAT (282-437): 1.35e-21: 104: 15.84
+	Mm
		140032 CASP9_MOUSE (84-479): 1.44e-99: 308: 23.78		BIRC3_MOUSE (268-395): 6.59e-19: 96.7: 22.66
+	Hs
		876944 CASP7_HUMAN (176-476): 1.44e-98: 300: 34.09		BIRC3_HUMAN (273-395): 1.46e-20: 101: 21.95
+	Hs
		876939 CASP7_HUMAN (176-476): 1.44e-98: 300: 34.09		XIAP_HUMAN (282-437): 1.32e-20: 100: 14.48
+	Hs
		876945 CASP7_HUMAN (176-476): 1.44e-98: 300: 34.09		BIRC2_HUMAN (254-436): 3.68e-19: 97.5: 12.45
+	Hs
		177664 CASP9_HUMAN (142-479): 5.98e-105: 320: 27.01		BIRC5_HUMAN (288-358): 1.39e-11: 67: 42.25
+	Hs
		177663 CASP7_HUMAN (176-476): 1.44e-98: 300: 34.09		BIRC5_HUMAN (288-358): 1.39e-11: 67: 42.25