HitPredict

Interactor 1: SL9A5 (Q14940)
Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5)
Gene: SLC9A5

Interactor 2: CHP1 (Q99653)
Calcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22)
Gene: CHP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	12576672, 33961781
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0015385 - sodium:proton antiporter activity GO:0051453 - regulation of intracellular pH
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 896 Hs			1 195
+	Hs
		212568 SL9A5_HUMAN (18-896): 0: 947: 100.00		CHP2_HUMAN (1-194): 5.82e-48: 157: 61.03
+	Rn
		895408 SL9A5_RAT (16-896): 0: 939: 94.33		CHP1_RAT (1-195): 5.21e-50: 162: 98.97
+	Rn
		1194995 SL9A5_RAT (16-896): 0: 939: 94.33		CHP2_RAT (1-194): 8.61e-45: 149: 61.03
+	Rn
		642815 SL9A3_RAT (12-808): 0: 706: 52.39		CHP1_RAT (1-195): 5.21e-50: 162: 98.97
+	Hs
		822764 SL9A3_HUMAN (23-810): 0: 701: 53.02		CHP1_HUMAN (1-195): 2.96e-50: 162: 100.00
+	Hs
		212565 SL9A3_HUMAN (23-810): 0: 701: 53.02		CHP2_HUMAN (1-194): 5.82e-48: 157: 61.03
+	Rn
		642816 SL9A3_RAT (12-808): 0: 706: 52.39		CHP2_RAT (1-194): 8.61e-45: 149: 61.03
+	Rn
		822754 SL9A2_RAT (5-766): 0: 677: 38.35		CHP1_RAT (1-195): 5.21e-50: 162: 98.97
+	Rn
		822755 SL9A2_RAT (5-766): 0: 677: 38.35		CHP2_RAT (1-194): 8.61e-45: 149: 61.03
+	Hs
		1305458 SL9A2_HUMAN (5-766): 0: 661: 37.86		CHP1_HUMAN (1-195): 2.96e-50: 162: 100.00
+	Hs
		212574 SL9A2_HUMAN (5-766): 0: 661: 37.86		CHP2_HUMAN (1-194): 5.82e-48: 157: 61.03
+	Hs
		586063 SL9A1_HUMAN (2-768): 0: 641: 36.06		CHP1_HUMAN (1-195): 2.96e-50: 162: 100.00
+	Hs
		212564 SL9A1_HUMAN (2-768): 0: 641: 36.06		CHP2_HUMAN (1-194): 5.82e-48: 157: 61.03
+	Hs
		586058 SL9A1_HUMAN (2-768): 0: 641: 36.06		CHP3_HUMAN (1-195): 1.08e-46: 154: 33.33
+	Rn
		642812 SL9A1_RAT (2-768): 0: 615: 35.63		CHP1_RAT (1-195): 5.21e-50: 162: 98.97
+	Rn
		642813 SL9A1_RAT (2-768): 0: 615: 35.63		CHP2_RAT (1-194): 8.61e-45: 149: 61.03
+	Hs
		1149580 SL9A4_HUMAN (24-690): 0: 594: 39.52		CHP1_HUMAN (1-195): 2.96e-50: 162: 100.00
+	Rn
		642818 SL9A4_RAT (4-688): 0: 591: 37.70		CHP1_RAT (1-195): 5.21e-50: 162: 98.97
+	Hs
		212570 SL9A4_HUMAN (24-690): 0: 594: 39.52		CHP2_HUMAN (1-194): 5.82e-48: 157: 61.03
+	Rn
		642819 SL9A4_RAT (4-688): 0: 591: 37.70		CHP2_RAT (1-194): 8.61e-45: 149: 61.03