HitPredict

Interactor 1: NMDE3 (Q14957)
Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)
Gene: GRIN2C

Interactor 2: DLG3 (Q92796)
Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR)
Gene: DLG3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.629

Property	Details
Experiments	11937501, 30126976
Identification Methods	affinity chromatography technology, pull down, p8 filamentous phage display
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0098839 - postsynaptic density membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1233 Hs			1 817
+	Rn
		962671 NMDE3_RAT (1-1233): 0: 1263: 87.62		DLG3_RAT (1-817): 0: 689: 95.17
+	Hs
		1021492 NMDE3_HUMAN (1-1233): 0: 1341: 100.00		DLG1_HUMAN (13-817): 0: 586: 63.90
+	Hs
		1028145 NMDE2_HUMAN (6-950): 0: 809: 52.78		DLG3_HUMAN (1-817): 0: 713: 100.00
+	Rn
		962664 NMDE2_RAT (6-950): 0: 808: 52.67		DLG3_RAT (1-817): 0: 689: 95.17
+	Mm
		936175 NMDE2_MOUSE (6-950): 0: 804: 52.57		DLG3_MOUSE (1-817): 0: 689: 95.05
+	Hs
		942343 NMDE3_HUMAN (1-1233): 0: 1341: 100.00		DLG4_HUMAN (50-285): 9.84e-26: 115: 20.25
+	Mm
		963785 NMDE3_MOUSE (1-1233): 0: 1292: 88.04		DLG4_MOUSE (50-285): 1.06e-25: 115: 20.25
+	Mm
		963751 NMDE2_MOUSE (6-950): 0: 804: 52.57		DLG1_MOUSE (3-817): 0: 592: 62.63
+	Hs
		1021485 NMDE2_HUMAN (6-950): 0: 809: 52.78		DLG1_HUMAN (13-817): 0: 586: 63.90
+	Rn
		962663 NMDE2_RAT (6-950): 0: 808: 52.67		DLG1_RAT (3-817): 0: 578: 61.42
+	Rn
		677782 NMDE3_RAT (1-1233): 0: 1263: 87.62		DLG4_RAT (50-282): 1.36e-25: 115: 20.50
+	Rn
		962655 NMDE1_RAT (1-921): 0: 751: 54.58		DLG1_RAT (3-817): 0: 578: 61.42
+	Hs
		942337 NMDE2_HUMAN (6-950): 0: 809: 52.78		DLG4_HUMAN (50-285): 9.84e-26: 115: 20.25
+	Rn
		677781 NMDE2_RAT (6-950): 0: 808: 52.67		DLG4_RAT (50-282): 1.36e-25: 115: 20.50
+	Mm
		963732 NMDE2_MOUSE (6-950): 0: 804: 52.57		DLG4_MOUSE (50-285): 1.06e-25: 115: 20.25
+	Hs
		1028140 NMDE2_HUMAN (6-950): 0: 809: 52.78		DLG2_HUMAN (312-547): 2.24e-16: 86: 21.40
+	Rn
		962666 NMDE2_RAT (6-950): 0: 808: 52.67		DLG2_RAT (312-547): 1.37e-16: 86.4: 21.40
+	Mm
		963769 NMDE2_MOUSE (6-950): 0: 804: 52.57		DLG2_MOUSE (312-547): 1.48e-16: 86.4: 21.40
+	Mm
		723533 NMDE1_MOUSE (1-921): 0: 753: 54.90		DLG4_MOUSE (50-285): 1.06e-25: 115: 20.25
+	Rn
		677780 NMDE1_RAT (1-921): 0: 751: 54.58		DLG4_RAT (50-282): 1.36e-25: 115: 20.50