Protein: DPOLA
DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180)

Gene: DPOLA, POLA1
Organism: Homo sapiens
Interactions: 84
UniProt ID: P09884

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000731 - DNA synthesis involved in DNA repair
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

488026

STN1
CST complex subunit STN1

3

0

High-throughput

0.796

High

488005

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

3

High-throughput

0.776

High

488007

DPOA2
DNA polymerase alpha subunit B

2

10

Small-scale

0.768

High

487987

PRI2
DNA primase large subunit

2

3

Small-scale

0.755

High

487977

RFA1
Replication protein A 70 kDa DNA-binding subunit

4

2

Small-scale

0.680

High

487986

PRI1
DNA primase small subunit

3

4

Small-scale

0.662

High

467989

HS90B
Heat shock protein HSP 90-beta

3

7

High-throughput

0.640

High

487976

CDK2
Cyclin-dependent kinase 2

2

6

Small-scale

0.629

High

488028

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.618

High

345288

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

3

High-throughput

0.584

High

487970

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

487980

STIP1
Stress-induced-phosphoprotein 1

2

4

High-throughput

0.584

High

487982

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

487997

H31
Histone H3.1

2

7

Small-scale

0.584

High

487998

RAE1L
mRNA export factor RAE1

2

2

High-throughput

0.584

High

486876

PARP1
Poly [ADP-ribose] polymerase 1

1

4

Small-scale

0.561

High

487972

CCNA2
Cyclin-A2

1

2

Small-scale

0.561

High

488002

RAD51
DNA repair protein RAD51 homolog 1

1

1

Small-scale

0.561

High

487978

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

0

Small-scale

0.549

High

442552

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.536

High

487973

BTF3
Transcription factor BTF3

1

1

High-throughput

0.536

High

487983

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

5

High-throughput

0.536

High

487984

MAGA3
Melanoma-associated antigen 3

1

1

High-throughput

0.536

High

488003

SSRP1
FACT complex subunit SSRP1

1

6

High-throughput

0.536

High

488008

SMC1A
Structural maintenance of chromosomes protein 1A

1

2

Small-scale

0.515

High

488031

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

0

High-throughput

0.513

High

281167

CDC45
Cell division control protein 45 homolog

1

4

Small-scale

0.501

High

443134

CDK1
Cyclin-dependent kinase 1

1

6

Small-scale

0.501

High

487969

CCNB1
G2/mitotic-specific cyclin-B1

1

2

Small-scale

0.501

High

487990

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

488024

SLD5
DNA replication complex GINS protein SLD5

1

7

Small-scale

0.501

High

488022

BT3L4
Transcription factor BTF3 homolog 4

1

1

High-throughput

0.489

High

155279

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

Small-scale

0.480

High

488019

HELB
DNA helicase B

1

0

Small-scale

0.480

High

155998

SOCS6
Suppressor of cytokine signaling 6

1

3

High-throughput

0.479

High

240558

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

259342

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

370997

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

413055

P53
Cellular tumor antigen p53

1

1

Small-scale

0.479

High

461057

HS90A
Heat shock protein HSP 90-alpha

1

7

High-throughput

0.479

High

487971

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

487975

CCNE1
G1/S-specific cyclin-E1

1

4

Small-scale

0.479

High

487985

CDK8
Cyclin-dependent kinase 8

1

6

High-throughput

0.479

High

487988

MCM2
DNA replication licensing factor MCM2

1

9

Small-scale

0.479

High

487989

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.479

High

487991

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

487992

H4
Histone H4

1

2

Small-scale

0.479

High

487993

H2B1C
Histone H2B type 1-C/E/F/G/I

1

6

High-throughput

0.479

High

487994

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

487995

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

1

Small-scale

0.479

High

487996

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.479

High

487999

H33
Histone H3.3

1

7

High-throughput

0.479

High

488000

CDK16
Cyclin-dependent kinase 16

1

7

High-throughput

0.479

High

488006

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

488009

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

488012

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.479

High

488014

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

488015

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

488017

SKAP1
Src kinase-associated phosphoprotein 1

1

3

High-throughput

0.479

High

488018

NUP43
Nucleoporin Nup43

1

5

High-throughput

0.479

High

488021

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

5

High-throughput

0.479

High

488023

MMS19
MMS19 nucleotide excision repair protein homolog

1

3

High-throughput

0.479

High

488027

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

488030

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

128733

MEN1
Menin

1

0

High-throughput

0.458

High

163038

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.458

High

487968

XRCC5
X-ray repair cross-complementing protein 5

1

0

Small-scale

0.458

High

487979

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

0

Small-scale

0.458

High

488010

AL1L2
Mitochondrial 10-formyltetrahydrofolate dehydrogenase

1

0

High-throughput

0.458

High

488011

TFDP3
Transcription factor Dp family member 3

1

0

High-throughput

0.458

High

488020

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

238767

SSX4
Protein SSX4

1

1

High-throughput

0.445

High

273393

KDM4A
Lysine-specific demethylase 4A

1

3

Small-scale

0.445

High

487981

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

488013

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.445

High

302734

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

5

High-throughput

0.437

High

411236

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

488001

RON
Macrophage-stimulating protein receptor

1

1

High-throughput

0.437

High

488025

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

488029

RBL2A
Rab-like protein 2A

1

1

High-throughput

0.437

High

487974

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

0

High-throughput

0.426

High

488004

TRAF3
TNF receptor-associated factor 3

1

0

High-throughput

0.426

High

488016

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.279

Low

105177

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025