HitPredict

Interactor 1: IMB1 (Q14974)
Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97)
Gene: KPNB1

Interactor 2: P121A (Q96HA1)
Nuclear envelope pore membrane protein POM 121 (Nuclear envelope pore membrane protein POM 121A) (Nucleoporin Nup121) (Pore membrane protein of 121 kDa)
Gene: POM121

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005635 - nuclear envelope GO:0005643 - nuclear pore GO:0005654 - nucleoplasm GO:0006606 - protein import into nucleus GO:0008139 - nuclear localization sequence binding and 1 others more... GO:0031965 - nuclear membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 876 Hs			1 1249
+	Hs
		65042 IMB1_HUMAN (1-876): 0: 635: 100.00		P121C_HUMAN (1-1249): 1.9e-77: 282: 93.93
+	Hs
		857978 IMB1_HUMAN (1-876): 0: 635: 100.00		NUP98_HUMAN (828-1223): 9.68e-19: 95.1: 19.77
+	Hs
		727254 IMB1_HUMAN (1-876): 0: 635: 100.00		NU214_HUMAN (91-1211): 3.61e-15: 83.5: 12.90
+	Hs
		1056831 IMB1_HUMAN (1-876): 0: 635: 100.00		MDC1_HUMAN (87-1249): 8.98e-14: 78.8: 9.17
+	Hs
		72728 IMB1_HUMAN (1-876): 0: 635: 100.00		B4DET5_HUMAN (79-778): 1.43e-13: 77.5: 11.14
+	Xl
		853819 IMB_XENLA (1-876): 0: 631: 94.52		Q5EWX9_XENLA (663-1249): 5.31e-12: 72.8: 17.09
+	Hs
		1060882 IMB1_HUMAN (1-876): 0: 635: 100.00		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Sc
		774378 IMB1_YEAST (2-871): 8.02e-148: 459: 33.33		NU159_YEAST (529-1071): 2.53e-11: 70.5: 18.34
+	Hs
		127345 IPO5_HUMAN (89-863): 6.82e-13: 75: 10.97		P121A_HUMAN (1-1249): 2.73e-82: 296: 100.00
+	Hs
		268793 SF3B1_HUMAN (146-866): 1.96e-78: 279: 12.23		ARI1B_HUMAN (128-1241): 3.11e-14: 80.3: 7.91
+	Dm
		1370249 Q9VPR5_DROME (134-849): 6.61e-81: 287: 12.04		Q9VLS7_DROME (1-721): 4.34e-11: 69.9: 6.70
+	Hs
		268831 SF3B1_HUMAN (146-866): 1.96e-78: 279: 12.23		CIC_HUMAN (128-1161): 2.11e-09: 64.5: 9.81
+	Hs
		268905 SF3B1_HUMAN (146-866): 1.96e-78: 279: 12.23		SRRM2_HUMAN (3-891): 8.36e-09: 62.5: 10.62
+	Hs
		127176 IPO5_HUMAN (89-863): 6.82e-13: 75: 10.97		MUC1_HUMAN (245-1245): 7.09e-53: 205: 12.49
+	Hs
		858024 TNPO1_HUMAN (125-870): 3.59e-28: 123: 12.21		NUP98_HUMAN (828-1223): 9.68e-19: 95.1: 19.77
+	Sc
		687954 IMB3_YEAST (3-831): 2.12e-34: 144: 16.29		NU159_YEAST (529-1071): 2.53e-11: 70.5: 18.34
+	Hs
		155553 TNPO2_HUMAN (124-869): 4.11e-25: 114: 14.04		NUP98_HUMAN (828-1223): 9.68e-19: 95.1: 19.77
+	Hs
		727300 TNPO1_HUMAN (125-870): 3.59e-28: 123: 12.21		NU214_HUMAN (91-1211): 3.61e-15: 83.5: 12.90
+	Hs
		127197 IPO5_HUMAN (89-863): 6.82e-13: 75: 10.97		NU214_HUMAN (91-1211): 3.61e-15: 83.5: 12.90