HitPredict

Interactor 1: NR1I3 (Q14994)
Nuclear receptor subfamily 1 group I member 3 (Constitutive activator of retinoid response) (Constitutive active response) (Constitutive androstane receptor) (CAR) (Orphan nuclear receptor MB67)
Gene: NR1I3

Interactor 2: PRGC1 (Q9UBK2)
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6)
Gene: PPARGC1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26407237
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 352 Hs			1 798
+	Hs
		587203 RXRA_HUMAN (8-351): 9.29e-108: 324: 23.99		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		265882 NR1I2_HUMAN (8-351): 3.57e-105: 317: 40.55		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		782680 HNF4A_HUMAN (2-351): 3.85e-101: 308: 24.43		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Mm
		250733 HNF4A_MOUSE (2-351): 1.38e-99: 304: 24.72		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Hs
		500377 RARB_HUMAN (9-351): 9.51e-99: 301: 27.25		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Mm
		250734 ERR3_MOUSE (2-351): 1.1e-96: 296: 24.15		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Hs
		914678 ERR3_HUMAN (2-351): 1.1e-96: 296: 24.15		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		370621 ESR1_HUMAN (2-351): 1.82e-94: 294: 21.66		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Mm
		250749 NR1H3_MOUSE (8-351): 1.12e-92: 285: 29.33		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Mm
		139246 ERR1_MOUSE (4-351): 6.71e-91: 280: 25.28		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Mm
		250740 ERR2_MOUSE (7-351): 8.22e-91: 280: 23.63		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Hs
		500508 THB_HUMAN (1-351): 2.09e-89: 277: 29.00		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		1269828 ESR2_HUMAN (2-352): 4.23e-88: 276: 21.76		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		782588 HNF4A_HUMAN (2-351): 3.85e-101: 308: 24.43		PRGC2_HUMAN (24-220): 2.66e-61: 226: 36.45
+	Hs
		914660 ERR3_HUMAN (2-351): 1.1e-96: 296: 24.15		PRGC2_HUMAN (24-220): 2.66e-61: 226: 36.45
+	Hs
		369945 ESR1_HUMAN (2-351): 1.82e-94: 294: 21.66		PRGC2_HUMAN (24-220): 2.66e-61: 226: 36.45
+	Hs
		500495 THB_HUMAN (1-351): 2.09e-89: 277: 29.00		PRGC2_HUMAN (24-220): 2.66e-61: 226: 36.45
+	Hs
		1138792 ESR2_HUMAN (2-352): 4.23e-88: 276: 21.76		PPRC1_HUMAN (663-798): 1.32e-57: 216: 61.03
+	Mm
		1257603 NR1H3_MOUSE (8-351): 1.12e-92: 285: 29.33		PRGC2_MOUSE (237-467): 1.97e-54: 205: 29.74
+	Mm
		139251 ERR1_MOUSE (4-351): 6.71e-91: 280: 25.28		PRGC2_MOUSE (237-467): 1.97e-54: 205: 29.74