Protein: SMAD9
Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9)

Gene: SMAD9
Organism: Homo sapiens
Interactions: 135
UniProt ID: O15198

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001649 - osteoblast differentiation
GO:0003700 - DNA-binding transcription factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181886

SMAD4
Mothers against decapentaplegic homolog 4

8

19

Small-scale

0.966

High

181876

SMAD3
Mothers against decapentaplegic homolog 3

3

19

High-throughput

0.861

High

181891

SMAD2
Mothers against decapentaplegic homolog 2

2

19

High-throughput

0.806

High

181958

MAN1
Inner nuclear membrane protein Man1

7

14

Small-scale

0.682

High

181878

PSG9
Pregnancy-specific beta-1-glycoprotein 9

3

3

High-throughput

0.667

High

181904

DSG4
Desmoglein-4

3

4

High-throughput

0.667

High

177629

SMAD7
Mothers against decapentaplegic homolog 7

1

18

Small-scale

0.618

High

181834

SMAD9
Mothers against decapentaplegic homolog 9

1

19

Small-scale

0.618

High

181838

KDM1A
Lysine-specific histone demethylase 1A

1

5

High-throughput

0.573

High

181924

ANM6
Protein arginine N-methyltransferase 6

1

5

High-throughput

0.573

High

181861

NOTC1
Neurogenic locus notch homolog protein 1

1

12

High-throughput

0.536

High

181933

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

2

High-throughput

0.536

High

181957

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

1

High-throughput

0.536

High

48319

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

2

High-throughput

0.508

High

62281

MTMRB
Myotubularin-related protein 11

1

4

High-throughput

0.508

High

161373

KMT2D
Histone-lysine N-methyltransferase 2D

1

14

High-throughput

0.508

High

181835

KDM6A
Lysine-specific demethylase 6A

1

11

High-throughput

0.508

High

181836

ZEB2
Zinc finger E-box-binding homeobox 2

1

15

High-throughput

0.508

High

181837

GANP
Germinal-center associated nuclear protein

1

5

High-throughput

0.508

High

181842

SF3B1
Splicing factor 3B subunit 1

1

5

High-throughput

0.508

High

181845

AP2A1
AP-2 complex subunit alpha-1

1

2

High-throughput

0.508

High

181851

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.508

High

181854

RFX1
MHC class II regulatory factor RFX1

1

7

High-throughput

0.508

High

181857

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

6

High-throughput

0.508

High

181862

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.508

High

181863

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

1

High-throughput

0.508

High

181865

ZNF83
Zinc finger protein 83

1

3

High-throughput

0.508

High

181869

MAP11
Methionine aminopeptidase 1

1

1

High-throughput

0.508

High

181870

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.508

High

181873

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.508

High

181874

DEST
Destrin

1

1

High-throughput

0.508

High

181875

LMO4
LIM domain transcription factor LMO4

1

7

High-throughput

0.508

High

181879

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

5

High-throughput

0.508

High

181880

FLI1
Friend leukemia integration 1 transcription factor

1

4

High-throughput

0.508

High

181882

DYST
Dystonin

1

5

High-throughput

0.508

High

181883

PPARD
Peroxisome proliferator-activated receptor delta

1

13

High-throughput

0.508

High

181885

PABP4
Polyadenylate-binding protein 4

1

1

High-throughput

0.508

High

181888

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

20

High-throughput

0.508

High

181890

PLEC
Plectin

1

5

High-throughput

0.508

High

181895

SVEP1
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

1

10

High-throughput

0.508

High

181896

CAMP1
Calmodulin-regulated spectrin-associated protein 1

1

1

High-throughput

0.508

High

181897

RN123
E3 ubiquitin-protein ligase RNF123

1

9

High-throughput

0.508

High

181899

E4F1
Transcription factor E4F1

1

3

High-throughput

0.508

High

181900

CTR9
RNA polymerase-associated protein CTR9 homolog

1

3

High-throughput

0.508

High

181901

SKI3
Superkiller complex protein 3

1

4

High-throughput

0.508

High

181903

CXXC5
CXXC-type zinc finger protein 5

1

3

High-throughput

0.508

High

181907

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

13

High-throughput

0.508

High

181909

MACOI
Macoilin

1

1

High-throughput

0.508

High

181910

ZN557
Zinc finger protein 557

1

3

High-throughput

0.508

High

181911

ZSCA4
Zinc finger and SCAN domain-containing protein 4

1

4

High-throughput

0.508

High

181913

ARI1B
AT-rich interactive domain-containing protein 1B

1

16

High-throughput

0.508

High

181915

ZN592
Zinc finger protein 592

1

2

High-throughput

0.508

High

181919

ABTB1
Ankyrin repeat and BTB/POZ domain-containing protein 1

1

4

High-throughput

0.508

High

181920

PLPL2
Patatin-like phospholipase domain-containing protein 2

1

1

High-throughput

0.508

High

181921

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.508

High

181922

OTUB1
Ubiquitin thioesterase OTUB1

1

5

High-throughput

0.508

High

181926

ASB2
Ankyrin repeat and SOCS box protein 2

1

4

High-throughput

0.508

High

181928

RANB9
Ran-binding protein 9

1

6

High-throughput

0.508

High

181931

DNJC7
DnaJ homolog subfamily C member 7

1

8

High-throughput

0.508

High

181932

PKP2
Plakophilin-2

1

7

High-throughput

0.508

High

181934

RHG09
Rho GTPase-activating protein 9

1

4

High-throughput

0.508

High

181940

UN45A
Protein unc-45 homolog A

1

6

High-throughput

0.508

High

181942

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

4

High-throughput

0.508

High

181944

HEYL
Hairy/enhancer-of-split related with YRPW motif-like protein

1

6

High-throughput

0.508

High

181946

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

20

High-throughput

0.508

High

181947

UBQL4
Ubiquilin-4

1

6

High-throughput

0.508

High

181950

MTMRA
Myotubularin-related protein 10

1

4

High-throughput

0.508

High

181951

RRBP1
Ribosome-binding protein 1

1

9

High-throughput

0.508

High

181952

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

8

High-throughput

0.508

High

181955

NAGK
N-acetyl-D-glucosamine kinase

1

1

High-throughput

0.508

High

181956

UBQL1
Ubiquilin-1

1

6

High-throughput

0.508

High

181959

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

4

High-throughput

0.508

High

181953

CBPA4
Carboxypeptidase A4

1

1

High-throughput

0.489

High

131231

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.486

High

142173

PIR
Pirin

1

0

High-throughput

0.486

High

181840

LRP5
Low-density lipoprotein receptor-related protein 5

1

0

High-throughput

0.486

High

181847

FRIL
Ferritin light chain

1

0

High-throughput

0.486

High

181856

1433T
14-3-3 protein theta

1

0

High-throughput

0.486

High

181860

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

0

High-throughput

0.486

High

181872

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.486

High

181894

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

0

High-throughput

0.486

High

181898

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.486

High

181905

LBN
Limbin

1

0

High-throughput

0.486

High

181906

CHSS2
Chondroitin sulfate synthase 2

1

0

High-throughput

0.486

High

181923

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.486

High

181929

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.486

High

181930

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.486

High

181935

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.486

High

181938

CLPB
Mitochondrial disaggregase

1

0

High-throughput

0.486

High

181948

DIAP3
Protein diaphanous homolog 3

1

0

High-throughput

0.486

High

95952

Z587B
Zinc finger protein 587B

1

4

High-throughput

0.481

High

181852

CSH2
Chorionic somatomammotropin hormone 2

1

4

High-throughput

0.481

High

181841

MED24
Mediator of RNA polymerase II transcription subunit 24

1

5

Small-scale

0.479

High

181846

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.479

High

181848

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

181859

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

4

High-throughput

0.479

High

181864

TOB1
Protein Tob1

1

12

Small-scale

0.479

High

181867

ZN143
Zinc finger protein 143

1

4

High-throughput

0.479

High

181868

HMGA2
High mobility group protein HMGI-C

1

3

Small-scale

0.479

High

181871

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

High-throughput

0.479

High

181877

VIGLN
Vigilin

1

2

High-throughput

0.479

High

181881

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

181892

EZH2
Histone-lysine N-methyltransferase EZH2

1

11

Small-scale

0.479

High

181902

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

181916

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.479

High

181917

KAT2B
Histone acetyltransferase KAT2B

1

13

Small-scale

0.479

High

181943

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

Small-scale

0.479

High

181949

MED29
Mediator of RNA polymerase II transcription subunit 29

1

1

Small-scale

0.479

High

181954

XPO7
Exportin-7

1

7

High-throughput

0.479

High

181839

MA1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

1

1

High-throughput

0.464

High

181849

CP11A
Cholesterol side-chain cleavage enzyme, mitochondrial

1

3

High-throughput

0.464

High

181850

SAP
Prosaposin

1

1

High-throughput

0.464

High

181866

AFF1
AF4/FMR2 family member 1

1

5

High-throughput

0.464

High

181884

PAPP1
Pappalysin-1

1

11

High-throughput

0.464

High

181887

TRI29
Tripartite motif-containing protein 29

1

3

High-throughput

0.464

High

181945

MA1C1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

1

1

High-throughput

0.464

High

181843

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

181914

SMAP2
Stromal membrane-associated protein 2

1

0

High-throughput

0.458

High

181936

DPY30
Protein dpy-30 homolog

1

0

Small-scale

0.458

High

181918

Q92967
Zinc finger protein zfp6

1

2

High-throughput

0.457

High

82045

ERVV1
Endogenous retrovirus group V member 1 Env polyprotein

1

1

High-throughput

0.439

High

181889

Q149M6
Exophilin 5

1

1

High-throughput

0.439

High

181927

PEO1
Twinkle mtDNA helicase

1

1

High-throughput

0.439

High

181893

CRY1
Cryptochrome-1

1

0

Small-scale

0.426

High

181912

EXPH5
Exophilin-5

1

1

High-throughput

0.417

High

181925

Q96MK7
cDNA FLJ32214 fis, clone PLACE6003705

1

1

High-throughput

0.417

High

181941

Q9H6V3
Twinkle mtDNA helicase

1

1

High-throughput

0.417

High

181858

GRN
Progranulin

2

0

High-throughput

0.323

High

181853

VSIG8
V-set and immunoglobulin domain-containing protein 8

2

0

High-throughput

0.288

High

181844

DKK1
Dickkopf-related protein 1

1

0

High-throughput

0.265

Low

181855

MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

1

0

High-throughput

0.265

Low

181908

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.265

Low

181937

TINAL
Tubulointerstitial nephritis antigen-like

1

0

High-throughput

0.265

Low

181939

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025