HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	14623875
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0048025 - negative regulation of mRNA splicing, via spliceosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 494 Hs			1 763
+	Hs
		1060973 SRSF1_HUMAN (3-166): 2.37e-57: 192: 41.42		DYR1A_HUMAN (1-763): 0: 620: 100.00
+	Hs
		1099335 SRSF6_HUMAN (1-180): 4.54e-52: 181: 78.50		DYR1A_HUMAN (1-763): 0: 620: 100.00
+	Hs
		1098959 SRSF9_HUMAN (3-216): 2.37e-52: 178: 36.53		DYR1A_HUMAN (1-763): 0: 620: 100.00
+	Hs
		1099069 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		DYR1A_HUMAN (1-763): 0: 620: 100.00
+	Hs
		550275 PABP1_HUMAN (1-189): 3.74e-31: 128: 19.50		DYR1A_HUMAN (1-763): 0: 620: 100.00
+	Hs
		1101947 PABP4_HUMAN (101-185): 3.05e-11: 67.7: 20.00		DYR1A_HUMAN (1-763): 0: 620: 100.00
+	Hs
		728209 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		AKT1_HUMAN (38-466): 1.32e-119: 369: 19.42
+	Hs
		728584 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		AKT2_HUMAN (38-467): 1.05e-118: 367: 19.11
+	Hs
		550125 PABP1_HUMAN (1-189): 3.74e-31: 128: 19.50		CDK2_HUMAN (156-421): 2.08e-118: 360: 26.76
+	At
		663909 RB45A_ARATH (4-175): 1.59e-20: 95.4: 17.02		CDKA1_ARATH (156-482): 1.21e-122: 371: 26.65
+	Zm
		11983 A0A1D6II08_MAIZE (106-303): 9.04e-13: 72.3: 14.71		A0A1D6FHK3_MAIZE (103-525): 2.11e-118: 364: 22.50
+	Sc
		403332 PABP_YEAST (72-188): 3.63e-10: 64.3: 14.75		YAK1_YEAST (19-586): 2.64e-116: 371: 29.05
+	At
		51568 RSZ33_ARATH (3-75): 5.26e-09: 59.3: 53.43		A1L4Y9_ARATH (129-483): 3.61e-56: 199: 32.90
+	At
		903594 RSZ33_ARATH (3-75): 5.26e-09: 59.3: 53.43		AFC3_ARATH (129-483): 3.61e-56: 199: 32.90
+	Zm
		33505 A0A1D6M1U3_MAIZE (100-205): 2.01e-12: 70.4: 17.59		A0A1D6L2E7_MAIZE (129-479): 1.14e-46: 181: 33.24