Protein: YAK1
Dual specificity protein kinase YAK1 (EC 2.7.12.1)

Gene: YAK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 93
UniProt ID: P14680

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

441016

KAPA
cAMP-dependent protein kinase type 1

4

17

Small-scale

0.908

High

441317

KAPB
cAMP-dependent protein kinase type 2

2

15

High-throughput

0.799

High

574546

YAK1
Dual specificity protein kinase YAK1

2

17

Small-scale

0.778

High

574597

EF3B
Elongation factor 3B

1

6

High-throughput

0.691

High

574619

YP247
WD repeat-containing protein YPL247C

4

20

High-throughput

0.691

High

534042

HSF
Heat shock transcription factor

3

5

Small-scale

0.667

High

470093

SPS1
Sporulation-specific protein 1

1

18

High-throughput

0.647

High

574566

MSN2
Zinc finger protein MSN2

1

2

Small-scale

0.647

High

574591

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

19

High-throughput

0.647

High

574599

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

17

High-throughput

0.647

High

574617

YRA1
RNA annealing protein YRA1

1

13

High-throughput

0.647

High

574556

MAS5
Mitochondrial protein import protein MAS5

1

7

High-throughput

0.646

High

574561

BMH1
Protein BMH1

2

18

Small-scale

0.624

High

574547

HSC82
ATP-dependent molecular chaperone HSC82

1

20

High-throughput

0.618

High

522916

HSP71
Heat shock protein SSA1

3

12

High-throughput

0.611

High

574593

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

14

Small-scale

0.611

High

574588

GTS1
Protein GTS1

1

16

High-throughput

0.590

High

574612

RBX1
RING-box protein HRT1

2

4

High-throughput

0.590

High

574577

POP2
Poly(A) ribonuclease POP2

1

4

Small-scale

0.578

High

403332

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

12

High-throughput

0.575

High

555220

RAD50
DNA repair protein RAD50

1

20

High-throughput

0.536

High

574552

VPS1
Vacuolar protein sorting-associated protein 1

1

12

High-throughput

0.536

High

574553

XRN1
5'-3' exoribonuclease 1

1

3

High-throughput

0.536

High

574555

NFS1
Cysteine desulfurase, mitochondrial

1

5

High-throughput

0.536

High

574557

NOT1
General negative regulator of transcription subunit 1

1

3

High-throughput

0.536

High

574562

XPO1
Exportin-1

1

9

High-throughput

0.536

High

574573

AHP1
Peroxiredoxin AHP1

1

1

High-throughput

0.536

High

574580

YJU6
Putative transcriptional regulatory protein YJL206C

1

2

High-throughput

0.536

High

574581

SWD1
COMPASS component SWD1

1

20

High-throughput

0.536

High

574598

DNM1
Dynamin-related protein DNM1

1

11

High-throughput

0.536

High

574604

TSA2
Peroxiredoxin TSA2

1

6

High-throughput

0.536

High

574606

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.536

High

574616

DCS2
Inactive diphosphatase DCS2

1

2

High-throughput

0.536

High

558545

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.513

High

574550

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.513

High

574594

RIB4
6,7-dimethyl-8-ribityllumazine synthase

1

0

High-throughput

0.513

High

574596

ELOA1
Elongin-A

1

0

High-throughput

0.513

High

574608

GDE
Glycogen debranching enzyme

1

0

High-throughput

0.513

High

574614

DIA2
Protein DIA2

1

0

High-throughput

0.513

High

513323

RL23B
Large ribosomal subunit protein uL14B

1

2

High-throughput

0.501

High

574548

AMPD
AMP deaminase

1

1

High-throughput

0.501

High

574554

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

2

High-throughput

0.501

High

574558

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

5

High-throughput

0.501

High

574559

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

3

High-throughput

0.501

High

574565

YKJ1
CRAL-TRIO domain-containing protein YKL091C

1

4

High-throughput

0.501

High

574579

IFH1
Protein IFH1

1

11

Small-scale

0.501

High

574584

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

1

1

High-throughput

0.501

High

574600

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

20

High-throughput

0.501

High

574605

CRF1
Transcription factor CRF1

1

1

Small-scale

0.501

High

574609

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

1

High-throughput

0.501

High

450512

FAS1
Fatty acid synthase subunit beta

1

2

High-throughput

0.500

High

453394

PYR1
Multifunctional protein URA2

1

7

High-throughput

0.500

High

531225

METK1
S-adenosylmethionine synthase 1

1

2

High-throughput

0.500

High

574551

HSP60
Heat shock protein 60, mitochondrial

1

17

High-throughput

0.500

High

574611

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

2

High-throughput

0.500

High

574615

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

2

High-throughput

0.500

High

574569

BMH2
Protein BMH2

1

18

Small-scale

0.494

High

574572

GLY1
Low specificity L-threonine aldolase

1

1

High-throughput

0.489

High

574576

FKS1
1,3-beta-glucan synthase component FKS1

1

1

High-throughput

0.489

High

574578

VATF
V-type proton ATPase subunit F

1

1

High-throughput

0.489

High

574620

GLT1
Glutamate synthase [NADH]

1

1

High-throughput

0.489

High

574549

RDS2
Regulator of drug sensitivity 2

1

0

High-throughput

0.480

High

574567

YBF5
Deoxyribonuclease Tat-D

1

0

High-throughput

0.480

High

574568

SEF1
Putative transcription factor SEF1

1

0

High-throughput

0.480

High

574571

YKC3
Uncharacterized protein YKL023W

1

0

High-throughput

0.480

High

574582

IES5
Ino eighty subunit 5

1

0

High-throughput

0.480

High

574595

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.480

High

574613

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

0

High-throughput

0.480

High

574570

DEF1
RNA polymerase II degradation factor 1

1

6

High-throughput

0.479

High

574574

ATG8
Autophagy-related protein 8

1

4

High-throughput

0.479

High

574610

PUF3
mRNA-binding protein PUF3

1

6

Small-scale

0.479

High

506232

HAP1
Heme-responsive zinc finger transcription factor HAP1

1

0

High-throughput

0.458

High

574560

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

574564

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

574592

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

574603

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

574575

UBX7
UBX domain-containing protein 7

1

6

High-throughput

0.457

High

574585

COX15
Heme A synthase COX15

1

1

High-throughput

0.457

High

574589

PRP17
Pre-mRNA-processing factor 17

1

17

High-throughput

0.457

High

574601

UBC7
Ubiquitin-conjugating enzyme E2 7

1

9

High-throughput

0.457

High

510141

HSP77
Import motor subunit, mitochondrial

1

18

High-throughput

0.445

High

525806

HSP72
Heat shock protein SSA2

1

12

High-throughput

0.445

High

543668

SSB1
Ribosome-associated molecular chaperone SSB1

1

12

High-throughput

0.445

High

574563

HSP7F
Heat shock protein homolog SSE1

1

19

High-throughput

0.445

High

574586

SSB2
Ribosome-associated molecular chaperone SSB2

1

12

High-throughput

0.445

High

574587

6P21
6-phosphofructo-2-kinase 1

1

9

High-throughput

0.445

High

574590

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.445

High

574618

GDIR
Rho GDP-dissociation inhibitor

1

1

High-throughput

0.439

High

504622

YL14A
Transposon Ty1-LR4 Gag polyprotein

1

0

High-throughput

0.426

High

574602

YM8V
Uncharacterized protein YMR295C

1

0

High-throughput

0.279

Low

574607

CSC1
Calcium permeable stress-gated cation channel 1

1

0

High-throughput

0.279

Low

574583

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025