HitPredict

Interactor 1: SUZ12 (Q15022)
Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog)
Gene: SUZ12

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.996

The method score is based on:

Property Details
Experiments 20075857, 24457600, 25470042, 26748827, 28514442, 27338022, 27705803, 27634302, 31281901, 24981860, 12435631, 35016035, 19026781, 18483221, 21378168, 26496610, 26130719, 27303043, 28068325, 29669287 and 33 others

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Identification Methods affinity chromatography technology, proximity labelling technology, enzymatic study, pull down, biochemical, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification, chromatin immunoprecipitation assay
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PRC2_HTH_1~VEFS-Box, VEFS-Box~preSET_CXC, SET~VEFS-Box
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001222 - transcription corepressor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 8 others

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Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 739
Hs

1 746
+ Mm
+ Mm
+ Mm
+ Hs
+ Dm
+ Mm
+ Hs
+ At
+ At
+ At
+ At

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Last updated: 15 Jul 2024