HitPredict

Interactor 1: U5S1 (Q15029)
116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)
Gene: EFTUD2

Interactor 2: UBP39 (Q53GS9)
Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein)
Gene: USP39

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	28515276, 35271311, 35627203, 19615732
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EFG_III~zf-UBP
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046540 - U4/U6 x U5 tri-snRNP complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 972 Hs			1 565
+	Hs
		1064564 U5S1_HUMAN (1-972): 0: 1062: 100.00		UBP7_HUMAN (10-557): 4.92e-116: 371: 14.06
+	Hs
		777040 U5S1_HUMAN (1-972): 0: 1062: 100.00		UBP8_HUMAN (177-564): 2.41e-101: 332: 19.80
+	Hs
		800583 U5S1_HUMAN (1-972): 0: 1062: 100.00		UBP5_HUMAN (13-493): 7.35e-87: 288: 15.81
+	Sc
		687430 EF2_YEAST (111-957): 0: 879: 36.04		UBP8_YEAST (80-552): 2.01e-107: 331: 16.80
+	Hs
		531291 EF2_HUMAN (111-957): 0: 915: 38.16		UBP36_HUMAN (225-564): 4.97e-62: 223: 20.69
+	Sc
		731735 SN114_YEAST (3-967): 0: 692: 32.82		SAD1_YEAST (71-556): 1.16e-128: 385: 28.18
+	Hs
		531135 EF2_HUMAN (111-957): 0: 915: 38.16		UBP4_HUMAN (222-340): 1.69e-10: 65.9: 33.33
+	Hs
		531086 EF2_HUMAN (111-957): 0: 915: 38.16		UBP11_HUMAN (439-556): 3.89e-09: 61.6: 31.09