Protein: PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)

Gene: PDE9A
Organism: Homo sapiens
Interactions: 56
UniProt ID: O76083

Gene Ontology (top 5):
GO:0004114 - 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005654 - nucleoplasm
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

303304

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

3

7

High-throughput

0.874

High

303325

TRI32
E3 ubiquitin-protein ligase TRIM32

8

0

High-throughput

0.726

High

303320

KR108
Keratin-associated protein 10-8

3

9

High-throughput

0.675

High

303328

U119A
Protein unc-119 homolog A

3

1

High-throughput

0.667

High

303306

BAG3
BAG family molecular chaperone regulator 3

3

0

High-throughput

0.646

High

303313

ST1E1
Sulfotransferase 1E1

3

0

High-throughput

0.646

High

303329

LAGE3
EKC/KEOPS complex subunit LAGE3

3

0

High-throughput

0.646

High

303333

CRY2
Cryptochrome-2

3

0

High-throughput

0.646

High

303349

GORS2
Golgi reassembly-stacking protein 2

2

0

High-throughput

0.618

High

303312

CLK1
Dual specificity protein kinase CLK1

3

4

High-throughput

0.616

High

140085

SDCB1
Syntenin-1

2

3

High-throughput

0.606

High

300273

KRT34
Keratin, type I cuticular Ha4

2

1

High-throughput

0.606

High

303310

KRA59
Keratin-associated protein 5-9

2

11

High-throughput

0.606

High

303316

KR122
Keratin-associated protein 12-2

2

9

High-throughput

0.606

High

303317

KR123
Keratin-associated protein 12-3

2

1

High-throughput

0.606

High

303319

KR107
Keratin-associated protein 10-7

2

9

High-throughput

0.606

High

303321

KR109
Keratin-associated protein 10-9

2

10

High-throughput

0.606

High

303322

WDR5
WD repeat-containing protein 5

2

2

High-throughput

0.606

High

303324

KRA11
Keratin-associated protein 1-1

2

9

High-throughput

0.606

High

303338

KRA13
Keratin-associated protein 1-3

2

9

High-throughput

0.606

High

181963

UBD
Ubiquitin D

2

0

High-throughput

0.580

High

303330

IQCB1
IQ calmodulin-binding motif-containing protein 1

2

0

High-throughput

0.580

High

303331

CDC37
Hsp90 co-chaperone Cdc37

2

0

High-throughput

0.580

High

303343

PRP18
Pre-mRNA-splicing factor 18

2

0

High-throughput

0.580

High

303335

NT2NA
Notch homolog 2 N-terminal-like protein A

2

1

High-throughput

0.573

High

303309

RBTN2
Rhombotin-2

1

1

High-throughput

0.573

High

303346

KRA92
Keratin-associated protein 9-2

1

9

High-throughput

0.573

High

303347

KRA42
Keratin-associated protein 4-2

1

9

High-throughput

0.573

High

303344

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

0

High-throughput

0.549

High

303305

HERC2
E3 ubiquitin-protein ligase HERC2

1

7

High-throughput

0.541

High

303314

FXR1
RNA-binding protein FXR1

1

2

High-throughput

0.541

High

303315

FXR2
RNA-binding protein FXR2

1

2

High-throughput

0.541

High

303337

HIPK1
Homeodomain-interacting protein kinase 1

1

6

High-throughput

0.541

High

303307

ERCC1
DNA excision repair protein ERCC-1

1

0

High-throughput

0.518

High

303308

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.518

High

303318

KR103
Keratin-associated protein 10-3

1

10

High-throughput

0.481

High

70562

NEU1B
E3 ubiquitin-protein ligase NEURL1B

1

2

Small-scale

0.479

High

302215

NEUL1
E3 ubiquitin-protein ligase NEURL1

1

2

Small-scale

0.479

High

303326

TRAF3
TNF receptor-associated factor 3

1

1

Small-scale

0.479

High

303327

KGP2
cGMP-dependent protein kinase 2

1

5

High-throughput

0.479

High

303336

NPHP3
Nephrocystin-3

1

1

High-throughput

0.479

High

303323

TFAP4
Transcription factor AP-4

1

0

High-throughput

0.460

High

303348

TRPV6
Transient receptor potential cation channel subfamily V member 6

1

0

High-throughput

0.460

High

303311

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.458

High

303350

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

0

High-throughput

0.458

High

303341

RSPRY
RING finger and SPRY domain-containing protein 1

1

3

High-throughput

0.437

High

303342

PHIPL
Phytanoyl-CoA hydroxylase-interacting protein-like

4

0

High-throughput

0.368

High

70062

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

303332

NFIL3
Nuclear factor interleukin-3-regulated protein

2

0

High-throughput

0.316

High

303334

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

0

High-throughput

0.316

High

303339

CI106
Putative uncharacterized protein encoded by LINC02913

1

0

High-throughput

0.299

High

303345

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.299

High

303351

ZMYM5
Zinc finger MYM-type protein 5

1

0

High-throughput

0.282

High

303352

Q9Y260
ABP/ZF

1

0

High-throughput

0.268

Low

303340

OCC1
Overexpressed in colon carcinoma 1 protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025