Protein: NR1I2
Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR)

Gene: NR1I2
Organism: Homo sapiens
Interactions: 48
UniProt ID: O75469

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

265870

NCOA1
Nuclear receptor coactivator 1

10

20

Small-scale

0.971

High

265850

RXRA
Retinoic acid receptor RXR-alpha

4

20

Small-scale

0.881

High

265855

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.817

High

265853

RXRB
Retinoic acid receptor RXR-beta

2

20

Small-scale

0.757

High

265882

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

4

20

Small-scale

0.698

High

265868

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

20

Small-scale

0.680

High

265885

NCOR2
Nuclear receptor corepressor 2

3

20

Small-scale

0.658

High

130310

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.621

High

265857

RXRG
Retinoic acid receptor RXR-gamma

1

20

High-throughput

0.621

High

265869

NCOA2
Nuclear receptor coactivator 2

1

20

Small-scale

0.621

High

265886

NCOA3
Nuclear receptor coactivator 3

1

20

Small-scale

0.621

High

265845

HS90A
Heat shock protein HSP 90-alpha

2

20

Small-scale

0.584

High

265843

UBR5
E3 ubiquitin-protein ligase UBR5

1

17

Small-scale

0.561

High

265848

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

16

Small-scale

0.561

High

265856

YAP1
Transcriptional coactivator YAP1

1

11

Small-scale

0.561

High

265875

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

16

Small-scale

0.561

High

261355

NCOR1
Nuclear receptor corepressor 1

1

20

Small-scale

0.552

High

265847

FGR
Tyrosine-protein kinase Fgr

1

14

High-throughput

0.541

High

265865

MK07
Mitogen-activated protein kinase 7

1

15

High-throughput

0.541

High

265867

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

20

High-throughput

0.541

High

265876

AP2C
Transcription factor AP-2 gamma

1

9

High-throughput

0.541

High

265866

NCOA6
Nuclear receptor coactivator 6

1

20

Small-scale

0.527

High

265880

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

10

Small-scale

0.523

High

154717

TCRG1
Transcription elongation regulator 1

1

15

High-throughput

0.515

High

265846

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.515

High

265851

KS6B1
Ribosomal protein S6 kinase beta-1

1

16

Small-scale

0.501

High

265852

PIT1
Pituitary-specific positive transcription factor 1

1

20

Small-scale

0.501

High

265861

UBC9
SUMO-conjugating enzyme UBC9

1

15

Small-scale

0.501

High

265863

MDM2
E3 ubiquitin-protein ligase Mdm2

1

8

Small-scale

0.501

High

265864

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.501

High

265883

DNM3L
DNA

1

7

Small-scale

0.501

High

265871

VAS1
V-type proton ATPase subunit S1

1

1

High-throughput

0.494

High

265842

TADA3
Transcriptional adapter 3

1

4

Small-scale

0.481

High

265859

PRS8
26S proteasome regulatory subunit 8

1

20

High-throughput

0.481

High

265881

CHM1A
Charged multivesicular body protein 1a

1

2

High-throughput

0.481

High

265844

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

265849

RO52
E3 ubiquitin-protein ligase TRIM21

1

4

Small-scale

0.479

High

265858

CEBPA
CCAAT/enhancer-binding protein alpha

1

19

Small-scale

0.479

High

265872

DDB1
DNA damage-binding protein 1

1

5

Small-scale

0.479

High

265873

RBBP7
Histone-binding protein RBBP7

1

20

Small-scale

0.479

High

265877

DNJC7
DnaJ homolog subfamily C member 7

1

10

Small-scale

0.479

High

265878

ANM1
Protein arginine N-methyltransferase 1

1

20

Small-scale

0.479

High

265884

TRRAP
Transformation/transcription domain-associated protein

1

10

High-throughput

0.479

High

265874

S13A5
Na(+)/citrate cotransporter

1

0

Small-scale

0.458

High

265854

ACTN2
Alpha-actinin-2

1

7

High-throughput

0.439

High

265879

CAB45
45 kDa calcium-binding protein

1

3

High-throughput

0.439

High

265860

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

8

Small-scale

0.437

High

265862

NUCB2
Nucleobindin-2

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024