HitPredict

Interactor 1: ARHG6 (Q15052)
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Gene: ARHGEF6

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	27173435, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDZ~SH3_2
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 776 Hs			1 337
+	Hs
		1049707 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		1049952 ARHG6_HUMAN (1-776): 0: 621: 100.00		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		1049703 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		1049725 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		1075407 ITSN1_HUMAN (18-575): 4.42e-86: 300: 15.88		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		548755 VAV_HUMAN (1-746): 1.59e-120: 384: 16.20		LIN7C_HUMAN (9-87): 8.5e-09: 56.6: 40.74
+	Mm
		57873 KALRN_MOUSE (203-772): 8.53e-72: 258: 17.67		DLG2_MOUSE (79-232): 1.54e-14: 76.5: 18.63
+	Mm
		57852 KALRN_MOUSE (203-772): 8.53e-72: 258: 17.67		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48