Protein: IPO4
Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)

Gene: IPO4
Organism: Homo sapiens
Interactions: 179
UniProt ID: Q8TEX9

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006606 - protein import into nucleus
GO:0008139 - nuclear localization sequence binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998580

H31
Histone H3.1

9

14

Small-scale

0.965

High

962309

RHOA
Transforming protein RhoA

3

6

High-throughput

0.817

High

981604

RAN
GTP-binding nuclear protein Ran

2

17

Small-scale

0.799

High

1017048

H33
Histone H3.3

2

14

Small-scale

0.789

High

1113811

CUL3
Cullin-3

2

7

High-throughput

0.789

High

969331

RS8
Small ribosomal subunit protein eS8

5

1

High-throughput

0.718

High

1353385

ASF1A
Histone chaperone ASF1A

4

3

Small-scale

0.699

High

1353375

ASF1B
Histone chaperone ASF1B

4

3

Small-scale

0.697

High

1161958

H31T
Histone H3.1t

1

14

Small-scale

0.691

High

372665

MYC
Myc proto-oncogene protein

4

6

High-throughput

0.686

High

959877

RS3A
Small ribosomal subunit protein eS1

3

3

High-throughput

0.656

High

1353348

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

3

5

Small-scale

0.656

High

1330719

SIGL1
SIGLEC family-like protein 1

2

6

High-throughput

0.628

High

843801

HD
Huntingtin

2

6

High-throughput

0.621

High

883624

CENPA
Histone H3-like centromeric protein A

1

14

High-throughput

0.618

High

955408

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.618

High

980947

H2B1C
Histone H2B type 1-C/E/F/G/I

1

4

High-throughput

0.618

High

988554

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.618

High

1353364

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.618

High

980036

H4
Histone H4

2

5

High-throughput

0.611

High

1353347

DNJC9
DnaJ homolog subfamily C member 9

2

1

High-throughput

0.611

High

277384

TP4A3
Protein tyrosine phosphatase type IVA 3

2

18

High-throughput

0.601

High

831116

CCNF
Cyclin-F

2

6

High-throughput

0.601

High

487563

PARP1
Poly [ADP-ribose] polymerase 1

2

8

High-throughput

0.584

High

951775

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

10

Small-scale

0.584

High

1135748

HAPR1
HUWE1-associated protein modifying stress responses 1

2

4

High-throughput

0.584

High

396580

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

262273

SCN2B
Sodium channel regulatory subunit beta-2

2

13

High-throughput

0.558

High

887447

CEBPD
CCAAT/enhancer-binding protein delta

1

8

Small-scale

0.554

High

169667

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

2

High-throughput

0.553

High

277941

SH3L1
Adapter SH3BGRL

2

0

High-throughput

0.547

High

250728

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.536

High

564112

CFTR
Cystic fibrosis transmembrane conductance regulator

1

9

High-throughput

0.536

High

690321

STOM
Stomatin

1

6

High-throughput

0.536

High

849386

RANG
Ran-specific GTPase-activating protein

1

20

High-throughput

0.536

High

856829

BAG6
Large proline-rich protein BAG6

1

3

High-throughput

0.536

High

872568

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.536

High

1006923

KC1G2
Casein kinase I isoform gamma-2

1

6

High-throughput

0.536

High

1022921

EFNB1
Ephrin-B1

1

6

High-throughput

0.536

High

1291639

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

6

High-throughput

0.536

High

1336052

ARRD4
Arrestin domain-containing protein 4

1

20

High-throughput

0.536

High

1349071

F174A
Membrane protein FAM174A

1

4

High-throughput

0.536

High

1353350

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

1

High-throughput

0.536

High

1353360

FACD2
Fanconi anemia group D2 protein

1

5

Small-scale

0.536

High

1353366

SENP3
Sentrin-specific protease 3

1

6

High-throughput

0.536

High

711381

SHC1
SHC-transforming protein 1

2

6

High-throughput

0.521

High

1227135

A16L1
Autophagy-related protein 16-1

2

9

High-throughput

0.521

High

1327770

SH2D3
SH2 domain-containing protein 3C

2

7

High-throughput

0.521

High

352499

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.515

High

459318

CATL1
Procathepsin L

1

1

High-throughput

0.515

High

693042

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.515

High

1353370

BRF2
Transcription factor IIIB 50 kDa subunit

1

3

High-throughput

0.515

High

1353371

NEK6
Serine/threonine-protein kinase Nek6

1

7

High-throughput

0.515

High

329954

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.513

High

376999

ANF
Natriuretic peptides A

1

0

High-throughput

0.513

High

618713

ML12A
Myosin regulatory light chain 12A

1

0

High-throughput

0.513

High

1206868

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.513

High

1311318

CDAN1
Codanin-1

1

0

Small-scale

0.513

High

1353359

RBM4
RNA-binding protein 4

1

0

High-throughput

0.513

High

1353363

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

913668

VAV2
Guanine nucleotide exchange factor VAV2

1

6

High-throughput

0.508

High

422702

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

1353378

NXF1
Nuclear RNA export factor 1

1

6

Small-scale

0.501

High

390695

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.493

High

1353386

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.493

High

1353389

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.493

High

253870

TPST2
Protein-tyrosine sulfotransferase 2

1

1

High-throughput

0.489

High

389451

FINC
Fibronectin

1

3

High-throughput

0.489

High

466941

ACM4
Muscarinic acetylcholine receptor M4

1

8

High-throughput

0.489

High

665900

AKAP5
A-kinase anchor protein 5

1

1

High-throughput

0.489

High

1142113

P2RY6
P2Y purinoceptor 6

1

10

High-throughput

0.489

High

1353361

TX101
Testis-expressed protein 101

1

2

High-throughput

0.489

High

1353390

NPTN
Neuroplastin

1

8

High-throughput

0.489

High

122965

SGK1
Serine/threonine-protein kinase Sgk1

1

3

High-throughput

0.479

High

168298

HAT1
Histone acetyltransferase type B catalytic subunit

1

2

Small-scale

0.479

High

294079

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

302907

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

6

High-throughput

0.479

High

315804

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

319931

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

320733

UBXN7
UBX domain-containing protein 7

1

4

High-throughput

0.479

High

350080

SNAI1
Zinc finger protein SNAI1

1

12

High-throughput

0.479

High

363611

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.479

High

412311

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.479

High

520221

ANDR
Androgen receptor

1

7

High-throughput

0.479

High

537585

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

580666

AMPN
Aminopeptidase N

1

3

High-throughput

0.479

High

589243

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

696028

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

731497

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

767069

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

9

High-throughput

0.479

High

777726

VGFR3
Vascular endothelial growth factor receptor 3

1

7

High-throughput

0.479

High

791566

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

800002

COIL
Coilin

1

2

High-throughput

0.479

High

879298

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

939949

TPTE
Putative tyrosine-protein phosphatase TPTE

1

12

High-throughput

0.479

High

941818

ARL4C
ADP-ribosylation factor-like protein 4C

1

4

High-throughput

0.479

High

941943

PEX3
Peroxisomal biogenesis factor 3

1

1

High-throughput

0.479

High

965106

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.479

High

983903

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

High-throughput

0.479

High

984212

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.479

High

1067532

EP300
Histone acetyltransferase p300

1

11

High-throughput

0.479

High

1088196

MERTK
Tyrosine-protein kinase Mer

1

8

High-throughput

0.479

High

1096603

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

3

High-throughput

0.479

High

1100160

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.479

High

1107049

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1161030

FSCN1
Fascin

1

1

High-throughput

0.479

High

1163384

CAH9
Carbonic anhydrase 9

1

7

Small-scale

0.479

High

1214533

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

1

High-throughput

0.479

High

1218566

MYSM1
Deubiquitinase MYSM1

1

2

Small-scale

0.479

High

1251092

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

11

High-throughput

0.479

High

1254788

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1276530

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1280360

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.479

High

1310610

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

6

High-throughput

0.479

High

1322408

SPICE
Spindle and centriole-associated protein 1

1

2

High-throughput

0.479

High

1334687

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

1353349

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1353351

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.479

High

1353353

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

1353354

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1353355

RUFY1
RUN and FYVE domain-containing protein 1

1

5

High-throughput

0.479

High

1353356

RING2
E3 ubiquitin-protein ligase RING2

1

7

High-throughput

0.479

High

1353357

DNJC7
DnaJ homolog subfamily C member 7

1

8

High-throughput

0.479

High

1353358

DUS23
Dual specificity protein phosphatase 23

1

16

High-throughput

0.479

High

1353362

YTHD1
YTH domain-containing family protein 1

1

11

High-throughput

0.479

High

1353367

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.479

High

1353368

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1353373

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

High-throughput

0.479

High

1353377

TLS1
Splicing factor C9orf78

1

5

High-throughput

0.479

High

1353379

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

1353380

TES
Testin

1

2

High-throughput

0.479

High

1353381

TBK1
Serine/threonine-protein kinase TBK1

1

4

High-throughput

0.479

High

1353383

CLC4E
C-type lectin domain family 4 member E

1

5

High-throughput

0.479

High

1353384

TRI33
E3 ubiquitin-protein ligase TRIM33

1

8

High-throughput

0.479

High

1353387

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

1353388

YTHD2
YTH domain-containing family protein 2

1

11

High-throughput

0.479

High

188947

TMPS2
Transmembrane protease serine 2

1

6

High-throughput

0.470

High

460852

CATB
Cathepsin B

1

2

High-throughput

0.470

High

680731

CATS
Cathepsin S

1

1

High-throughput

0.470

High

1286841

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.470

High

1353346

CLC4D
C-type lectin domain family 4 member D

1

5

High-throughput

0.470

High

880943

MTR1B
Melatonin receptor type 1B

1

2

High-throughput

0.464

High

1161795

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.458

High

166361

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

7

High-throughput

0.445

High

944005

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

1093149

STK4
Serine/threonine-protein kinase 4

1

6

High-throughput

0.445

High

1240909

S27A4
Long-chain fatty acid transport protein 4

1

17

High-throughput

0.445

High

106341

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

136944

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

3

High-throughput

0.437

High

191013

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.437

High

353463

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.437

High

610025

VGFR1
Vascular endothelial growth factor receptor 1

1

7

High-throughput

0.437

High

650317

FGFR3
Fibroblast growth factor receptor 3

1

14

High-throughput

0.437

High

720281

UFO
Tyrosine-protein kinase receptor UFO

1

7

High-throughput

0.437

High

768726

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

787054

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

7

High-throughput

0.437

High

1178273

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

1186119

ANR55
Ankyrin repeat domain-containing protein 55

1

5

High-throughput

0.437

High

1249049

LMBRL
Protein LMBR1L

1

4

High-throughput

0.437

High

1250174

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

1271378

KCTD9
BTB/POZ domain-containing protein KCTD9

1

6

High-throughput

0.437

High

1288540

ZN598
E3 ubiquitin-protein ligase ZNF598

1

5

High-throughput

0.437

High

1327093

FBXL6
F-box/LRR-repeat protein 6

1

5

High-throughput

0.437

High

1353365

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.437

High

1353372

ANLN
Anillin

1

8

High-throughput

0.437

High

1353376

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

3

High-throughput

0.437

High

48990

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.426

High

1353369

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1353382

AGO2
Protein argonaute-2

1

0

High-throughput

0.426

High

1086

SIM26
Small integral membrane protein 26

1

4

High-throughput

0.407

High

94435

D6RAT0
Small ribosomal subunit protein eS1

1

3

High-throughput

0.407

High

171526

S27A2
Long-chain fatty acid transport protein 2

1

17

High-throughput

0.407

High

1335643

MOT11
Monocarboxylate transporter 11

1

4

High-throughput

0.407

High

1353352

S35B4
Nucleotide sugar transporter SLC35B4

1

2

High-throughput

0.407

High

1292659

PRSR2
Proline and serine-rich protein 2

2

0

High-throughput

0.328

High

1353374

T11L1
T-complex protein 11-like protein 1

2

0

High-throughput

0.316

High

505104

BNIP5
Protein BNIP5

1

0

High-throughput

0.279

Low

1165374

ODAPH
Odontogenesis associated phosphoprotein

1

0

High-throughput

0.279

Low

1162440

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025