HitPredict

Interactor 1: ARHG6 (Q15052)
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Gene: ARHGEF6

Interactor 2: RHOV (Q96L33)
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)
Gene: RHOV

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 776 Hs			1 236
+	Hs
		1066032 ARHG6_HUMAN (1-776): 0: 621: 100.00		RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48
+	Hs
		925289 ARHG6_HUMAN (1-776): 0: 621: 100.00		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		892381 ARHG6_HUMAN (1-776): 0: 621: 100.00		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		564535 ARHG6_HUMAN (1-776): 0: 621: 100.00		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		545388 ARHG6_HUMAN (1-776): 0: 621: 100.00		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		894026 ARHG6_HUMAN (1-776): 0: 621: 100.00		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Gg
		1141019 ARHG6_CHICK (1-775): 0: 589: 73.55		Q6LC82_CHICK (32-217): 3.34e-76: 230: 53.23
+	Hs
		1066050 ARHG6_HUMAN (1-776): 0: 621: 100.00		RHOJ_HUMAN (32-214): 8.3e-59: 186: 50.27
+	Hs
		1049714 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48
+	Hs
		1049724 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RHOV_HUMAN (1-236): 3.37e-76: 231: 100.00
+	Hs
		925271 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		892365 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		564524 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		545368 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		893997 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Hs
		1049733 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		RHOJ_HUMAN (32-214): 8.3e-59: 186: 50.27
+	Hs
		951449 VAV3_HUMAN (1-746): 7.26e-127: 400: 16.03		RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44
+	Hs
		925718 VAV3_HUMAN (1-746): 7.26e-127: 400: 16.03		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		901037 VAV3_HUMAN (1-746): 7.26e-127: 400: 16.03		RHOA_HUMAN (33-215): 9.31e-73: 221: 42.62
+	Hs
		548671 VAV_HUMAN (1-746): 1.59e-120: 384: 16.20		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39