Protein: ZFY21
Zinc finger FYVE domain-containing protein 21 (ZF21)

Gene: ZFY21, ZFYVE21
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q9BQ24

Gene Ontology (top 5):
GO:0005768 - endosome
GO:0005925 - focal adhesion
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1139251

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

3

1

High-throughput

0.616

High

1409910

PRAF1
Prenylated Rab acceptor protein 1

3

2

High-throughput

0.616

High

572163

TRI27
Zinc finger protein RFP

1

10

High-throughput

0.573

High

1093938

TRAF1
TNF receptor-associated factor 1

1

5

High-throughput

0.573

High

1307777

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

4

High-throughput

0.573

High

1409911

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

20

High-throughput

0.573

High

606031

CAN2
Calpain-2 catalytic subunit

1

1

Small-scale

0.561

High

1380405

RNF34
E3 ubiquitin-protein ligase RNF34

1

5

Small-scale

0.561

High

325589

YIF1A
Protein YIF1A

2

1

High-throughput

0.553

High

1161830

ZSC26
Zinc finger and SCAN domain-containing protein 26

1

6

High-throughput

0.536

High

300823

KRT38
Keratin, type I cuticular Ha8

1

20

High-throughput

0.523

High

685932

KRA59
Keratin-associated protein 5-9

1

4

High-throughput

0.523

High

950641

KR108
Keratin-associated protein 10-8

1

3

High-throughput

0.523

High

1146120

K1H1
Keratin, type I cuticular Ha1

1

20

High-throughput

0.523

High

1205960

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

13

High-throughput

0.523

High

1218004

MYOME
Myomegalin

1

10

High-throughput

0.523

High

1230225

K1C40
Keratin, type I cytoskeletal 40

1

20

High-throughput

0.523

High

1277371

NT2NA
Notch homolog 2 N-terminal-like protein A

1

4

High-throughput

0.523

High

1409907

RTN4
Reticulon-4

1

3

High-throughput

0.523

High

603353

KPCA
Protein kinase C alpha type

1

2

High-throughput

0.515

High

966807

1433G
14-3-3 protein gamma

1

20

High-throughput

0.515

High

1139821

SETB1
Histone-lysine N-methyltransferase SETDB1

1

4

High-throughput

0.515

High

1371263

KAT5
Histone acetyltransferase KAT5

1

1

High-throughput

0.515

High

1365937

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

1

2

Small-scale

0.512

High

1051042

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.501

High

372977

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.489

High

363784

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

474935

VIME
Vimentin

1

19

Small-scale

0.479

High

535461

BIP
Endoplasmic reticulum chaperone BiP

1

10

Small-scale

0.479

High

537796

HSP7C
Heat shock cognate 71 kDa protein

1

7

Small-scale

0.479

High

550442

PABP1
Polyadenylate-binding protein 1

1

4

Small-scale

0.479

High

631437

RAB5A
Ras-related protein Rab-5A

1

15

Small-scale

0.479

High

772984

MYH9
Myosin-9

1

8

Small-scale

0.479

High

775283

FUS
RNA-binding protein FUS

1

7

Small-scale

0.479

High

846448

MATR3
Matrin-3

1

2

Small-scale

0.479

High

869079

TISD
mRNA decay activator protein ZFP36L2

1

1

High-throughput

0.479

High

965848

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

2

Small-scale

0.479

High

1033188

EWS
RNA-binding protein EWS

1

3

Small-scale

0.479

High

1368873

RBP56
TATA-binding protein-associated factor 2N

1

2

Small-scale

0.479

High

1409909

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1406207

OSMR
Oncostatin-M-specific receptor subunit beta

1

2

High-throughput

0.470

High

950113

KR105
Keratin-associated protein 10-5

1

3

High-throughput

0.470

High

1210660

Q5SUL5
HLA class I histocompatibility antigen A alpha chain

1

3

High-throughput

0.470

High

1347369

LMO3
LIM domain only protein 3

1

2

High-throughput

0.470

High

457652

TBB5
Tubulin beta chain

1

9

Small-scale

0.457

High

949976

KR103
Keratin-associated protein 10-3

1

3

High-throughput

0.439

High

141637

DDX3X
ATP-dependent RNA helicase DDX3X

1

6

Small-scale

0.437

High

386153

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

17

Small-scale

0.437

High

461869

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.437

High

468737

HS90B
Heat shock protein HSP 90-beta

1

7

Small-scale

0.437

High

600915

HSP76
Heat shock 70 kDa protein 6

1

7

Small-scale

0.437

High

608723

DDX5
Probable ATP-dependent RNA helicase DDX5

1

4

Small-scale

0.437

High

610853

TCPA
T-complex protein 1 subunit alpha

1

11

Small-scale

0.437

High

655320

SFPQ
Splicing factor, proline- and glutamine-rich

1

4

Small-scale

0.437

High

729424

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

8

Small-scale

0.437

High

773261

MYH10
Myosin-10

1

8

Small-scale

0.437

High

910659

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

5

Small-scale

0.437

High

968796

PRS4
26S proteasome regulatory subunit 4

1

3

Small-scale

0.437

High

996828

TBA1B
Tubulin alpha-1B chain

1

9

Small-scale

0.437

High

1027700

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

Small-scale

0.437

High

1090512

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

Small-scale

0.437

High

1102076

PABP4
Polyadenylate-binding protein 4

1

4

Small-scale

0.437

High

1108680

TBB3
Tubulin beta-3 chain

1

9

Small-scale

0.437

High

1134697

NUMA1
Nuclear mitotic apparatus protein 1

1

15

Small-scale

0.437

High

1277774

MYH14
Myosin-14

1

8

Small-scale

0.437

High

1291163

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

7

Small-scale

0.437

High

1333193

AFG2A
ATPase family gene 2 protein homolog A

1

2

Small-scale

0.437

High

1334835

SERB1
SERPINE1 mRNA-binding protein 1

1

2

Small-scale

0.437

High

1357885

CTF18
Chromosome transmission fidelity protein 18 homolog

1

4

Small-scale

0.437

High

1363311

DDX1
ATP-dependent RNA helicase DDX1

1

5

Small-scale

0.437

High

1369362

DDX17
Probable ATP-dependent RNA helicase DDX17

1

4

Small-scale

0.437

High

1399492

IPO9
Importin-9

1

4

Small-scale

0.437

High

1409908

ATD3A
ATPase family AAA domain-containing protein 3A

1

6

Small-scale

0.437

High

1409912

APC7
Anaphase-promoting complex subunit 7

1

2

Small-scale

0.437

High

1409915

PKP3
Plakophilin-3

1

5

Small-scale

0.437

High

1409916

SNX9
Sorting nexin-9

1

9

Small-scale

0.437

High

1393438

REEP6
Receptor expression-enhancing protein 6

3

0

High-throughput

0.352

High

1259197

SMIM5
Small integral membrane protein 5

2

0

High-throughput

0.316

High

1316817

CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4

2

0

High-throughput

0.316

High

1247404

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.299

High

1409913

ASC
Apoptosis-associated speck-like protein containing a CARD

1

0

Small-scale

0.261

Low

1409914

FBX7
F-box only protein 7

1

0

High-throughput

0.261

Low

531998

PPBN
Alkaline phosphatase, germ cell type

1

0

Small-scale

0.249

Low

1066171

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025