HitPredict

Interactor 1: ARHG6 (Q15052)
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Gene: ARHGEF6

Interactor 2: SYNCI (Q9H7C4)
Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1)
Gene: SYNC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 776 Hs			1 482
+	Hs
		1049734 ARHG7_HUMAN (1-719): 4.57e-168: 506: 54.22		SYNCI_HUMAN (1-482): 9.08e-167: 481: 100.00
+	Hs
		1078909 ITSN1_HUMAN (18-575): 4.42e-86: 300: 15.88		SYNCI_HUMAN (1-482): 9.08e-167: 481: 100.00
+	Hs
		535403 ITSN1_HUMAN (18-575): 4.42e-86: 300: 15.88		GFAP_HUMAN (154-456): 5.8e-99: 306: 23.27
+	Hs
		443876 PKHG1_HUMAN (179-720): 1.21e-80: 284: 19.53		VIME_HUMAN (154-456): 2.16e-104: 321: 21.70
+	Hs
		569085 ITSN1_HUMAN (18-575): 4.42e-86: 300: 15.88		DESM_HUMAN (154-456): 6.3e-86: 273: 20.76
+	Hs
		957982 FGD1_HUMAN (239-698): 2.56e-80: 279: 18.33		AINX_HUMAN (170-456): 1.08e-91: 289: 25.25
+	Mm
		57833 KALRN_MOUSE (203-772): 8.53e-72: 258: 17.67		AINX_MOUSE (170-456): 3.21e-92: 290: 25.57
+	Hs
		782006 PKHG1_HUMAN (179-720): 1.21e-80: 284: 19.53		PERI_HUMAN (154-456): 6.88e-79: 255: 22.50