Protein: SH3R2
E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (Heart protein phosphatase 1-binding protein) (HEPP1) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2)

Gene: SH3R2, SH3RF2
Organism: Homo sapiens
Interactions: 54
UniProt ID: Q8TEC5

Gene Ontology (top 5):
GO:0004864 - protein phosphatase inhibitor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0008157 - protein phosphatase 1 binding
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211993

EFS
Embryonal Fyn-associated substrate

2

20

High-throughput

0.700

High

957800

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

4

High-throughput

0.698

High

1205903

MTUS2
Microtubule-associated tumor suppressor candidate 2

4

18

High-throughput

0.683

High

967871

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

3

5

Small-scale

0.680

High

786742

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

3

5

Small-scale

0.645

High

1331985

BANP
Protein BANP

2

1

High-throughput

0.628

High

1063470

GOGA2
Golgin subfamily A member 2

4

12

High-throughput

0.623

High

1352431

AMOL2
Angiomotin-like protein 2

4

15

High-throughput

0.623

High

931570

RD23A
UV excision repair protein RAD23 homolog A

1

6

Small-scale

0.618

High

1280034

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

19

Small-scale

0.618

High

63237

VP37C
Vacuolar protein sorting-associated protein 37C

2

20

High-throughput

0.606

High

336728

BAG4
BAG family molecular chaperone regulator 4

2

3

High-throughput

0.606

High

1352428

NEK6
Serine/threonine-protein kinase Nek6

2

13

High-throughput

0.606

High

1311757

HOMEZ
Homeobox and leucine zipper protein Homez

2

2

High-throughput

0.584

High

1352430

AKP8L
A-kinase anchor protein 8-like

2

0

High-throughput

0.580

High

1352422

RBPMS
RNA-binding protein with multiple splicing

2

2

High-throughput

0.576

High

70380

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

1228687

C102B
Coiled-coil domain-containing protein 102B

2

5

High-throughput

0.553

High

391375

FRIL
Ferritin light chain

2

1

High-throughput

0.549

High

1114954

CUL4A
Cullin-4A

1

4

High-throughput

0.536

High

1307754

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

11

High-throughput

0.515

High

354743

PAK4
Serine/threonine-protein kinase PAK 4

1

20

Small-scale

0.512

High

422698

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

869506

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

7

Small-scale

0.501

High

1352425

ZY11B
Protein zyg-11 homolog B

1

0

High-throughput

0.493

High

386013

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

10

High-throughput

0.481

High

173119

XPO1
Exportin-1

1

1

High-throughput

0.479

High

461748

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.479

High

468637

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.479

High

684323

DDX6
Probable ATP-dependent RNA helicase DDX6

1

3

Small-scale

0.479

High

685654

U2AF2
Splicing factor U2AF 65 kDa subunit

1

3

Small-scale

0.479

High

988549

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.479

High

1045558

TF65
Transcription factor p65

1

3

High-throughput

0.479

High

1100916

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

Small-scale

0.479

High

1352420

DDX1
ATP-dependent RNA helicase DDX1

1

2

Small-scale

0.479

High

1352427

CPAP
Centrosomal P4.1-associated protein

1

5

High-throughput

0.470

High

1139650

SYK
Lysine--tRNA ligase

1

0

Small-scale

0.458

High

1277868

NUFP2
FMR1-interacting protein NUFIP2

1

0

Small-scale

0.458

High

1352426

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

Small-scale

0.458

High

1213424

AT7L2
Ataxin-7-like protein 2

1

2

High-throughput

0.439

High

1332410

CBY2
Protein chibby homolog 2

1

2

High-throughput

0.439

High

1352424

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.439

High

643527

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

2

Small-scale

0.437

High

717119

ECHM
Enoyl-CoA hydratase, mitochondrial

1

2

Small-scale

0.437

High

953945

IF4A1
Eukaryotic initiation factor 4A-I

1

6

Small-scale

0.437

High

1187052

LSM12
Protein LSM12

1

1

Small-scale

0.437

High

1308870

CCD50
Coiled-coil domain-containing protein 50

1

1

Small-scale

0.437

High

1352421

FAN
Protein FAN

1

2

Small-scale

0.437

High

47273

A0A6Q8KRG2
Golgin subfamily A member 2

1

12

High-throughput

0.417

High

1352429

PNMA2
Paraneoplastic antigen Ma2

1

5

High-throughput

0.407

High

239150

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.313

High

608312

EGLN
Endoglin

1

0

High-throughput

0.261

Low

1352423

TMM74
Transmembrane protein 74

1

0

High-throughput

0.232

Low

1352432

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025