HitPredict

Interactor 1: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: RIF1 (Q5UIP0)
Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)
Gene: RIF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30110629, 33742100
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2414 Hs			1 2472
+	Hs
		674198 BRD2_HUMAN (1035-1159): 9.61e-30: 131: 31.20		RIF1_HUMAN (1-2472): 0: 1719: 100.00
+	Hs
		1141165 BRD3_HUMAN (1055-1159): 9.1e-30: 130: 30.48		RIF1_HUMAN (1-2472): 0: 1719: 100.00
+	Hs
		1129619 MDC1_HUMAN (455-1061): 1.21e-12: 76.3: 11.82		RIF1_HUMAN (1-2472): 0: 1719: 100.00
+	Hs
		1067841 EP300_HUMAN (1-2414): 0: 1100: 100.00		BSN_HUMAN (1011-2368): 1.46e-36: 155: 8.41
+	Hs
		1067466 EP300_HUMAN (1-2414): 0: 1100: 100.00		RBBP6_HUMAN (1213-2173): 5.47e-27: 123: 9.31
+	Hs
		1067330 EP300_HUMAN (1-2414): 0: 1100: 100.00		MDC1_HUMAN (958-2272): 4.97e-18: 93.9: 10.74
+	Hs
		1129788 TRI33_HUMAN (608-1201): 7.14e-42: 171: 14.59		MDC1_HUMAN (958-2272): 4.97e-18: 93.9: 10.74
+	Hs
		1141194 BRD3_HUMAN (1055-1159): 9.1e-30: 130: 30.48		RBBP6_HUMAN (1213-2173): 5.47e-27: 123: 9.31
+	Hs
		861238 CBP_HUMAN (1876-2412): 3.02e-09: 65.2: 10.52		MAP1B_HUMAN (925-2416): 3.36e-43: 177: 10.23
+	Hs
		1141173 BRD3_HUMAN (1055-1159): 9.1e-30: 130: 30.48		NIPBL_HUMAN (948-1837): 3.17e-19: 98.1: 12.40
+	Hs
		674162 BRD2_HUMAN (1035-1159): 9.61e-30: 131: 31.20		MDC1_HUMAN (958-2272): 4.97e-18: 93.9: 10.74
+	Hs
		1129599 BRD3_HUMAN (1055-1159): 9.1e-30: 130: 30.48		MDC1_HUMAN (958-2272): 4.97e-18: 93.9: 10.74
+	Hs
		1280892 CBP_HUMAN (1876-2412): 3.02e-09: 65.2: 10.52		CNTRL_HUMAN (924-2161): 1.92e-36: 154: 10.94
+	Hs
		674271 BRD2_HUMAN (1035-1159): 9.61e-30: 131: 31.20		TITIN_HUMAN (1353-2455): 8.62e-10: 66.9: 8.12
+	Dm
		119660 M9PB30_DROME (1785-2142): 3.01e-09: 65.2: 10.06		M9PB30_DROME (1825-2465): 7.6e-22: 106: 8.20
+	Hs
		1129588 MDC1_HUMAN (455-1061): 1.21e-12: 76.3: 11.82		MDC1_HUMAN (958-2272): 4.97e-18: 93.9: 10.74
+	Hs
		1129671 CBP_HUMAN (1876-2412): 3.02e-09: 65.2: 10.52		MDC1_HUMAN (958-2272): 4.97e-18: 93.9: 10.74
+	Mm
		1455913 PCLO_MOUSE (1899-2380): 9.5e-16: 86.7: 14.08		PCLO_MOUSE (1905-2438): 1.78e-09: 66.1: 7.79