Protein: RBBP6
E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)

Gene: RBBP6
Organism: Homo sapiens
Interactions: 227
UniProt ID: Q7Z6E9

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0003723 - RNA binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

889598

CLK2
Dual specificity protein kinase CLK2

4

11

High-throughput

0.699

High

889762

CLK3
Dual specificity protein kinase CLK3

4

11

High-throughput

0.699

High

1006504

SRPK2
SRSF protein kinase 2

4

15

High-throughput

0.691

High

1279858

ZCH18
Zinc finger CCCH domain-containing protein 18

4

14

High-throughput

0.691

High

1111803

TRA2A
Transformer-2 protein homolog alpha

3

6

High-throughput

0.667

High

1160184

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

3

14

High-throughput

0.667

High

1279874

TP4AP
Short transient receptor potential channel 4-associated protein

3

1

High-throughput

0.662

High

1279901

ZN576
Zinc finger protein 576

3

4

High-throughput

0.662

High

993635

UBC9
SUMO-conjugating enzyme UBC9

1

3

High-throughput

0.656

High

1028261

MDM2
E3 ubiquitin-protein ligase Mdm2

3

2

Small-scale

0.656

High

1279925

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

5

Small-scale

0.647

High

1159983

SRSF7
Serine/arginine-rich splicing factor 7

2

14

High-throughput

0.644

High

1145250

RNPS1
RNA-binding protein with serine-rich domain 1

3

9

High-throughput

0.643

High

1279899

PININ
Pinin

3

0

High-throughput

0.638

High

1279866

ZBT38
Zinc finger and BTB domain-containing protein 38

2

1

Small-scale

0.636

High

396417

ESR1
Estrogen receptor

3

20

Small-scale

0.633

High

987735

GRB2
Growth factor receptor-bound protein 2

2

11

High-throughput

0.633

High

868363

CDX1
Homeobox protein CDX-1

2

3

High-throughput

0.628

High

134783

SAP18
Histone deacetylase complex subunit SAP18

3

0

High-throughput

0.628

High

970712

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.618

High

1279933

PRP19
Pre-mRNA-processing factor 19

1

14

High-throughput

0.618

High

1279893

RBM4
RNA-binding protein 4

2

9

Small-scale

0.611

High

462491

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

6

High-throughput

0.601

High

866743

CAZA2
F-actin-capping protein subunit alpha-2

2

3

High-throughput

0.600

High

994625

YBOX1
Y-box-binding protein 1

1

3

Small-scale

0.586

High

129220

MEN1
Menin

2

4

High-throughput

0.584

High

260129

BRD4
Bromodomain-containing protein 4

2

14

High-throughput

0.584

High

472856

RU17
U1 small nuclear ribonucleoprotein 70 kDa

2

12

High-throughput

0.584

High

1083395

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

2

3

Small-scale

0.584

High

1153769

NCOA1
Nuclear receptor coactivator 1

2

1

Small-scale

0.584

High

480204

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.576

High

1279929

ZN346
Zinc finger protein 346

2

0

High-throughput

0.576

High

1128042

DHX8
ATP-dependent RNA helicase DHX8

2

4

High-throughput

0.571

High

1226971

A16L1
Autophagy-related protein 16-1

2

17

High-throughput

0.571

High

414111

P53
Cellular tumor antigen p53

1

5

Small-scale

0.561

High

761738

HSP74
Heat shock 70 kDa protein 4

1

8

Small-scale

0.561

High

1279906

NEK6
Serine/threonine-protein kinase Nek6

1

7

Small-scale

0.549

High

442755

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.537

High

1279891

FAP24
Fanconi anemia core complex-associated protein 24

1

0

High-throughput

0.536

High

191691

MAGB2
Melanoma-associated antigen B2

1

2

High-throughput

0.536

High

463141

YES
Tyrosine-protein kinase Yes

1

3

High-throughput

0.536

High

478100

SNRPA
U1 small nuclear ribonucleoprotein A

1

8

High-throughput

0.536

High

506968

POTEI
POTE ankyrin domain family member I

1

9

High-throughput

0.536

High

542092

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

574343

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

2

High-throughput

0.536

High

879731

MAPK2
MAP kinase-activated protein kinase 2

1

2

High-throughput

0.536

High

1016493

SRSF3
Serine/arginine-rich splicing factor 3

1

18

High-throughput

0.536

High

1062031

SRSF4
Serine/arginine-rich splicing factor 4

1

14

High-throughput

0.536

High

1065268

SSRP1
FACT complex subunit SSRP1

1

13

High-throughput

0.536

High

1099415

SRSF6
Serine/arginine-rich splicing factor 6

1

15

High-throughput

0.536

High

1112572

CUL1
Cullin-1

1

13

High-throughput

0.536

High

1149108

SF3A1
Splicing factor 3A subunit 1

1

8

High-throughput

0.536

High

1168833

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

10

High-throughput

0.536

High

1279862

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

6

High-throughput

0.536

High

1279877

LAR4B
La-related protein 4B

1

3

High-throughput

0.536

High

1279879

EZH1
Histone-lysine N-methyltransferase EZH1

1

18

High-throughput

0.536

High

1279883

PABP5
Polyadenylate-binding protein 5

1

11

High-throughput

0.536

High

1279890

H2AJ
Histone H2A.J

1

9

High-throughput

0.536

High

1279871

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.513

High

1279924

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

284684

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

1

2

High-throughput

0.508

High

297644

PIAS1
E3 SUMO-protein ligase PIAS1

1

4

High-throughput

0.508

High

336120

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

6

High-throughput

0.508

High

567439

TCTP
Translationally-controlled tumor protein

1

1

High-throughput

0.508

High

913662

VAV2
Guanine nucleotide exchange factor VAV2

1

12

High-throughput

0.508

High

1160502

SMN
Survival motor neuron protein

1

1

High-throughput

0.508

High

1279886

RCC1L
RCC1-like G exchanging factor-like protein

1

7

High-throughput

0.508

High

1279923

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

2

High-throughput

0.508

High

889447

CLK1
Dual specificity protein kinase CLK1

1

11

High-throughput

0.501

High

1279880

ARRD3
Arrestin domain-containing protein 3

1

12

High-throughput

0.489

High

1279884

ERLEC
Endoplasmic reticulum lectin 1

1

1

High-throughput

0.489

High

1279930

ANR50
Ankyrin repeat domain-containing protein 50

1

14

High-throughput

0.489

High

578676

GLNA
Glutamine synthetase

1

0

High-throughput

0.486

High

1279907

ACO13
Acyl-coenzyme A thioesterase 13

1

0

High-throughput

0.486

High

1279937

FBX7
F-box only protein 7

1

0

High-throughput

0.486

High

168716

CSKP
Peripheral plasma membrane protein CASK

1

7

High-throughput

0.481

High

577459

ETS1
Protein C-ets-1

1

10

Small-scale

0.481

High

948867

CD81
CD81 antigen

1

1

Small-scale

0.481

High

1279881

APC16
Anaphase-promoting complex subunit 16

1

1

Small-scale

0.481

High

1279910

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.481

High

157556

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.479

High

168050

RGS12
Regulator of G-protein signaling 12

1

4

Small-scale

0.479

High

194249

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

223152

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

228300

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

1

High-throughput

0.479

High

285341

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

318817

RHBT1
Rho-related BTB domain-containing protein 1

1

8

High-throughput

0.479

High

323462

TRI37
E3 ubiquitin-protein ligase TRIM37

1

10

High-throughput

0.479

High

331095

KI20A
Kinesin-like protein KIF20A

1

15

High-throughput

0.479

High

340759

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

1

4

Small-scale

0.479

High

372433

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.479

High

406332

MYCN
N-myc proto-oncogene protein

1

11

High-throughput

0.479

High

447165

NPM
Nucleophosmin

1

4

High-throughput

0.479

High

460580

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

3

High-throughput

0.479

High

508205

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

High-throughput

0.479

High

551126

PCNA
Proliferating cell nuclear antigen

1

4

High-throughput

0.479

High

558236

XRCC6
X-ray repair cross-complementing protein 6

1

5

High-throughput

0.479

High

589038

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

615410

SON
Protein SON

1

16

High-throughput

0.479

High

637036

VATB2
V-type proton ATPase subunit B, brain isoform

1

5

High-throughput

0.479

High

683481

IKBA
NF-kappa-B inhibitor alpha

1

19

Small-scale

0.479

High

695825

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

750438

CSTF2
Cleavage stimulation factor subunit 2

1

10

Small-scale

0.479

High

768537

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

807479

IF4A3
Eukaryotic initiation factor 4A-III

1

8

High-throughput

0.479

High

830990

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

862261

YAP1
Transcriptional coactivator YAP1

1

15

High-throughput

0.479

High

867247

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.479

High

879228

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

884662

SYHM
Histidine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

904882

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

911626

NCBP2
Nuclear cap-binding protein subunit 2

1

8

High-throughput

0.479

High

916680

PPP5
Serine/threonine-protein phosphatase 5

1

16

High-throughput

0.479

High

942715

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

17

High-throughput

0.479

High

979899

H4
Histone H4

1

8

High-throughput

0.479

High

995668

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.479

High

1004769

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

1033042

EWS
RNA-binding protein EWS

1

9

High-throughput

0.479

High

1045453

TF65
Transcription factor p65

1

5

High-throughput

0.479

High

1048021

TLE3
Transducin-like enhancer protein 3

1

15

High-throughput

0.479

High

1056820

FMR1
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.479

High

1065846

MZT1
Mitotic-spindle organizing protein 1

1

1

High-throughput

0.479

High

1067466

EP300
Histone acetyltransferase p300

1

16

High-throughput

0.479

High

1085582

FOXO1
Forkhead box protein O1

1

11

High-throughput

0.479

High

1086254

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.479

High

1092329

CSTF3
Cleavage stimulation factor subunit 3

1

3

Small-scale

0.479

High

1097389

CBX3
Chromobox protein homolog 3

1

10

High-throughput

0.479

High

1104965

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

5

High-throughput

0.479

High

1113540

CUL3
Cullin-3

1

13

High-throughput

0.479

High

1128767

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

1132790

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

9

High-throughput

0.479

High

1135724

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

1137819

TNIP1
TNFAIP3-interacting protein 1

1

18

High-throughput

0.479

High

1141194

BRD3
Bromodomain-containing protein 3

1

16

High-throughput

0.479

High

1146720

PCBP1
Poly(rC)-binding protein 1

1

7

High-throughput

0.479

High

1155506

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

High-throughput

0.479

High

1241002

L2GL2
LLGL scribble cell polarity complex component 2

1

5

High-throughput

0.479

High

1241670

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

1254425

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

1276421

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1279855

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

1279856

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

1279860

DHX40
Probable ATP-dependent RNA helicase DHX40

1

4

High-throughput

0.479

High

1279861

SMC5
Structural maintenance of chromosomes protein 5

1

11

High-throughput

0.479

High

1279863

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

14

Small-scale

0.479

High

1279864

FBXW8
F-box/WD repeat-containing protein 8

1

11

High-throughput

0.479

High

1279865

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.479

High

1279868

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1279872

SP7
Transcription factor Sp7

1

13

High-throughput

0.479

High

1279873

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

1279876

TOPB1
DNA topoisomerase 2-binding protein 1

1

12

High-throughput

0.479

High

1279878

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1279882

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

19

High-throughput

0.479

High

1279887

YTDC1
YTH domain-containing protein 1

1

4

High-throughput

0.479

High

1279888

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.479

High

1279889

CDC5L
Cell division cycle 5-like protein

1

5

High-throughput

0.479

High

1279892

DDX23
Probable ATP-dependent RNA helicase DDX23

1

3

High-throughput

0.479

High

1279894

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

10

High-throughput

0.479

High

1279895

FACD2
Fanconi anemia group D2 protein

1

6

High-throughput

0.479

High

1279896

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

13

High-throughput

0.479

High

1279897

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

8

High-throughput

0.479

High

1279904

CLK4
Dual specificity protein kinase CLK4

1

12

High-throughput

0.479

High

1279905

RC3H2
Roquin-2

1

15

High-throughput

0.479

High

1279909

ANLN
Anillin

1

8

High-throughput

0.479

High

1279911

RNC
Ribonuclease 3

1

9

High-throughput

0.479

High

1279912

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1279913

NLE1
Notchless protein homolog 1

1

8

High-throughput

0.479

High

1279914

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

2

High-throughput

0.479

High

1279915

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1279916

BCLF1
Bcl-2-associated transcription factor 1

1

12

High-throughput

0.479

High

1279917

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

1

5

Small-scale

0.479

High

1279918

HECW2
E3 ubiquitin-protein ligase HECW2

1

7

High-throughput

0.479

High

1279921

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1279922

TBK1
Serine/threonine-protein kinase TBK1

1

4

High-throughput

0.479

High

1279926

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

20

High-throughput

0.479

High

1279931

HECD1
E3 ubiquitin-protein ligase HECTD1

1

11

High-throughput

0.479

High

1279934

SRRM2
Serine/arginine repetitive matrix protein 2

1

17

High-throughput

0.479

High

1279935

TR150
Thyroid hormone receptor-associated protein 3

1

17

High-throughput

0.479

High

890980

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

1

High-throughput

0.470

High

366184

HPT
Haptoglobin

1

1

High-throughput

0.464

High

455916

ASGR1
Asialoglycoprotein receptor 1

1

1

High-throughput

0.464

High

389606

RET4
Retinol-binding protein 4

1

0

High-throughput

0.460

High

972467

RS14
Small ribosomal subunit protein uS11

1

0

Small-scale

0.460

High

1279919

TFP11
Tuftelin-interacting protein 11

1

0

High-throughput

0.460

High

1279927

AGO2
Protein argonaute-2

1

0

Small-scale

0.460

High

345193

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.458

High

583321

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

939634

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

1279857

SERC5
Serine incorporator 5

1

0

Small-scale

0.458

High

1279869

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1279875

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1279885

THOC1
THO complex subunit 1

1

0

High-throughput

0.458

High

1279920

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

High-throughput

0.458

High

290614

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.445

High

430090

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

615849

RL17
Large ribosomal subunit protein uL22

1

2

High-throughput

0.445

High

686237

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.445

High

985743

RL11
Large ribosomal subunit protein uL5

1

1

High-throughput

0.445

High

1034590

AK17A
A-kinase anchor protein 17A

1

6

High-throughput

0.445

High

1099140

SRSF5
Serine/arginine-rich splicing factor 5

1

15

High-throughput

0.445

High

1209329

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

Small-scale

0.445

High

1279870

SNIP1
Smad nuclear-interacting protein 1

1

4

High-throughput

0.445

High

1279898

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

17

High-throughput

0.445

High

1279900

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

17

High-throughput

0.445

High

1279902

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

1279936

LC7L2
Putative RNA-binding protein Luc7-like 2

1

1

High-throughput

0.445

High

281527

LRCH4
Leucine-rich repeat and calponin homology domain-containing protein 4

1

2

Small-scale

0.439

High

192832

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.438

High

302873

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

17

High-throughput

0.437

High

1044357

HSF2
Heat shock factor protein 2

1

1

High-throughput

0.437

High

1242668

KLC3
Kinesin light chain 3

1

4

High-throughput

0.437

High

1279908

LUC7L
Putative RNA-binding protein Luc7-like 1

1

1

High-throughput

0.437

High

1279928

NUP50
Nuclear pore complex protein Nup50

1

2

High-throughput

0.437

High

208298

RRP8
Ribosomal RNA-processing protein 8

1

0

High-throughput

0.426

High

213185

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

1126824

SLBP
Histone RNA hairpin-binding protein

1

0

High-throughput

0.426

High

1279867

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.426

High

1279903

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.426

High

1279932

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.426

High

301521

WFS1
Wolframin

1

0

High-throughput

0.268

Low

366361

PLMN
Plasminogen

1

0

High-throughput

0.265

Low

388847

APOH
Beta-2-glycoprotein 1

1

0

High-throughput

0.265

Low

1279938

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.265

Low

522276

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

946565

EVA1C
Protein eva-1 homolog C

1

0

Small-scale

0.251

Low

657619

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.249

Low

1279859

STX12
Syntaxin-12

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025