HitPredict

Interactor 1: NECT1 (Q15223)
Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111)
Gene: NECTIN1

Interactor 2: NECT4 (Q96NY8)
Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4) [Cleaved into: Processed poliovirus receptor-related protein 4]
Gene: NECTIN4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.870

The method score is based on:

Property Details
Experiments 21982860, 22902367, 12011057
Identification Methods pull down, cosedimentation in solution, surface plasmon resonance, protein array, fluorescence-activated cell sorting
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains C2-set_2~C2-set_2, C2-set_2~Ig_3, C2-set_2~V-set, Ig_3~Ig_3, Ig_3~V-set, V-set~V-set
Common GO terms GO:0001618 - virus receptor activity
GO:0005886 - plasma membrane
GO:0005912 - adherens junction
GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007157 - heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 517
Hs

1 510
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Last updated: 15 Jul 2024