HitPredict

Interactor 1: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Interactor 2: DCAF4 (Q8WV16)
DDB1- and CUL4-associated factor 4 (WD repeat-containing protein 21A)
Gene: DCAF4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.961

Property	Details
Experiments	16949367, 28514442, 30945288, 33961781, 35813202, 16964240, 19966799
Identification Methods	affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1140 Hs			1 495
+	Mm
		1112300 DDB1_MOUSE (1-1140): 0: 1422: 99.65		Q99LF7_MOUSE (1-495): 0: 849: 80.48
+	Hs
		1082285 DDB1_HUMAN (1-1140): 0: 1424: 100.00		DC4L2_HUMAN (101-494): 0: 694: 74.62
+	Hs
		1082210 DDB1_HUMAN (1-1140): 0: 1424: 100.00		DC4L1_HUMAN (101-495): 0: 681: 76.77