HitPredict

Interactor 1: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Interactor 2: MEP50 (Q9BQA1)
Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
Gene: WDR77

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	29846670
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process GO:0031465 - Cul4B-RING E3 ubiquitin ligase complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1140 Hs			1 342
+	Hs
		245605 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL1X_HUMAN (162-342): 3.97e-28: 116: 15.46
+	Hs
		1082374 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL1R_HUMAN (206-337): 3.38e-19: 90.1: 13.01
+	Hs
		903254 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	At
		1154740 DDB1A_ARATH (2-1140): 0: 1255: 52.09		FY_ARATH (3-340): 1.13e-76: 249: 20.82
+	At
		221826 DDB1B_ARATH (3-1140): 0: 1248: 50.92		FY_ARATH (3-340): 1.13e-76: 249: 20.82
+	Hs
		1082263 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5B_HUMAN (3-106): 2.76e-09: 59.7: 7.90
+	At
		1340748 DDB1A_ARATH (2-1140): 0: 1255: 52.09		HTD1_ARATH (83-320): 3.04e-37: 140: 19.66
+	Hs
		1073168 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		NLE1_HUMAN (114-333): 2.06e-53: 184: 18.05
+	Hs
		1073094 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Sc
		791185 CFT1_YEAST (11-1125): 0: 678: 14.79		PFS2_YEAST (78-327): 8.69e-79: 250: 25.69
+	Sc
		744701 CFT1_YEAST (11-1125): 0: 678: 14.79		TAF5_YEAST (15-267): 2.96e-38: 146: 14.77
+	Hs
		1014197 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		WDR33_HUMAN (58-331): 3.52e-67: 230: 17.86
+	At
		1154738 CPSF1_ARATH (30-483): 9.88e-97: 339: 18.73		FY_ARATH (3-340): 1.13e-76: 249: 20.82
+	Hs
		1014208 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		NLE1_HUMAN (114-333): 2.06e-53: 184: 18.05
+	Hs
		1014128 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		TAF5_HUMAN (178-328): 1.2e-21: 98: 18.42
+	Hs
		197009 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40
+	Sp
		251795 CFT1_SCHPO (11-588): 1.38e-93: 330: 16.62		PFS2_SCHPO (25-214): 1.81e-19: 91: 11.28